Protein Alignment GPC6 and dlp

DIOPT Version :10

• Sequence 1: NP_005699.1
• Gene: GPC6 / 10082
• HGNCID: 4454
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_524071.2
• Gene: dlp / 39596
• FlyBaseID: FBgn0041604
• Length: 765
• Species: Drosophila melanogaster
• Alignment Length: 653
• Identity: 222/653 - (33%)
• Similarity: 316/653 - (48%)
• Gaps: 134/653 - (20%)

Human    11 PLLGLLLSL-----------------------PAGA-------DVKARSCGEVRQAYGAKGFSLA 45
            |||.|||:.                       |||.       |..:.:|..|...:.|:|....
  Fly    31 PLLLLLLTTHLPPTLQADNGPAPQVAALAAPNPAGGVAGSSIIDQFSPNCSAVTHIFQARGIDAI 95

Human    46 DIPYQEIAGEHLRIC--PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEF 108
            :||.:......||.|  |...||||..||.:::.||:.:.|...::....:.....|:..||.:.
  Fly    96 EIPQKPSNERVLRYCESPSVGTCCTYNMETRMAMQSRQQLEGHTKDQISRMSGILGSKATKFKDI 160

Human   109 FRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMF 173
            |..||:.:....|.||:||||::|.:||.||.|||.||:.|:..|.|:|.|:::.|:..|.::||
  Fly   161 FTALLKESRTQFNSMFIRTYGVIYERNSYVFSDLFKELETYFANGRVDLLEVMDKFFNTLYQKMF 225

Human   174 QLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKV 238
            .::|.||.|.|:|:.|||::..:||||||||.||.:|:.|:|:|.||:.|.||...|||.:|..|
  Fly   226 TVLNTQYTFDENYMRCVSEHMKELKPFGDVPDKLSVQIKRSFVATRTYGQALTTASEVAKKVLNV 290

Human   239 SPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLE 303
            .....|..||.||.:|..|:|. |.:||.|||:||:||||..|.:.|:||..|..||..|||||.
  Fly   291 RLNADCTGALTKMQHCGACKGY-TEKPCTNYCVNVIKGCLHYQHEFDSEWENFAMAMDKVAERLL 354

Human   304 GPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRS------------ARSA 356
            |.|||..|::|:::||||||||.|::...::.:||||||:||.....||            |||
  Fly   355 GSFNIVMVVEPLNIKISEAIMNFQDSGQDITNRVFQGCGRPKLKKMKRSISPKLQGVQILNARS- 418

Human   357 PENFNT--------------RFRPYNPEERPTTA-------AGTS-------------------- 380
            |...:|              ..|...|..:.|:|       .|.|
  Fly   419 PVEADTLDIDETLDEAIVLRERRAAEPGSQETSAQQSQEQGVGKSGNGGGGGGGNNRRQQQRRKQ 483

Human   381 ----------------------------LDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTS 417
                                        |||:|.||::::|..||.||.||:::|.:|.:.:.:.
  Fly   484 QQQRRKQQNNRDDNDDDDNESGGGREPILDRIVRDIRQRVKDYKKFWSNLPHSVCSNEDIASSSD 548

Human   418 NEEECWNGHSKARYLPEIMNDGLTNQINNPEV--DVDITRPDTFIRQQIMALRVMTNKLKNAYNG 480
            .:..|||||:..||:..|    .|...:|||.  :...|:....:..|:..|:.....|:|||||
  Fly   549 VDGMCWNGHTIDRYMHSI----TTEHGSNPEFTGNPASTKQTAQMASQLSHLKNAIVHLRNAYNG 609

Human   481 NDVNFQDTSD---ESSGSGSGSGCMDDVCPTE------FE---FVTTEAPAVDPDRREVDSSAAQ 533
            .||.:.:..:   ..||:|||||..||....|      ||   ....|.|:||.|..: |..|..
  Fly   610 QDVEWSEQEELPYAGSGAGSGSGSEDDEDDDEGSGLGPFEPSHKPDVERPSVDADNDD-DEDAGG 673

Human   534 RGH 536
            |||
  Fly   674 RGH 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPC6	NP_005699.1	Glypican	22..548	CDD:460084	214/619 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..376		10/53 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..501		9/23 (39%)
dlp	NP_524071.2	Glypican	79..619	CDD:460084	190/545 (35%)