Protein Alignment GPC6 and dally

DIOPT Version :9

• Sequence 1: NP_005699.1
• Gene: GPC6 / 10082
• HGNCID: 4454
• Length: 555
• Species: Homo sapiens
• Sequence 2: NP_001246685.1
• Gene: dally / 39013
• FlyBaseID: FBgn0263930
• Length: 626
• Species: Drosophila melanogaster
• Alignment Length: 606
• Identity: 143/606 - (23%)
• Similarity: 228/606 - (37%)
• Gaps: 110/606 - (18%)

Human    24 DVKARSC--GEVRQAYGAKG-FSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFEN 85
            |.:|:..  |...|....|. |...||.......|...||..  .||....|.:|..::...||.
  Fly    55 DSRAKDAVGGSTHQCDAVKSYFESIDIKSSGTYSEKGAICGG--NCCNNATELELRDKAAGMFEQ 117

Human    86 LVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRY- 149
            |:...:..:|....:..|:|.....||.:.:|...:.:|.:.|..:...:..:...|:||:..:
  Fly   118 LLHHHTSSLRGVLETNAKQFQSHVLELAQISENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHL 182

Human   150 -----YTGGN------------VNLEEMLNDFWARLLERMF-QLINPQYHFS--------EDYLE 188
                 ||..|            .||||.:..|:.:|....: |::    |.|        |||:.
  Fly   183 IYTSNYTNSNGQLGRRGIGSVQSNLEEAVRHFFVQLFPVAYHQMV----HLSKNNLGDLHEDYVN 243

Human   189 CVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKV---SPTPGCIRALMK 250
            |:....|::.||||:|::::..:.::...:..|:..|....||.:....:   ..|..|...|:|
  Fly   244 CLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADALYGEQLTDTCKLHLLK 308

Human   251 MLYCPYCRG-----LPTVRPCNNYCLNVMKGCLANQAD-LDTEWNLFIDAM-LLVAERLEGPFNI 308
            |.|||.|.|     ....:.|..||.|||:||.|..|. ||:.|:..:|:: .||...:.....|
  Fly   309 MHYCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAEYAGLLDSPWSGVVDSLNNLVTTHILSDTGI 373

Human   309 ESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAP---ALRSARSAPENFNTRFRPYNPE 370
            .:|:..:....|||||....|..::..||.:.||.|...|   ....||..|...|.::
  Fly   374 INVIKHLQTYFSEAIMAAMHNGPELEKKVKKTCGTPSLTPYSSGEPDARPPPHKNNVKW------ 432

Human   371 ERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEI 435
                   .|..|..:......:..||:.::.:....|.::.   .:.::..||:|.....|...:
  Fly   433 -------ATDPDPGMVLFLSTIDKSKEFYTTIVDNFCDEQQ---HSRDDHSCWSGDRFGDYTQLL 487

Human   436 MNDGLTNQINNPEV-----------------------DVDITRPDTFIRQQIMALRVMTNKLKNA 477
            :|.|..:|..||||                       .:....|.    ..|.|...:.|.:...
  Fly   488 INPGTDSQRYNPEVPFNAKAQTGKLNELVDKLFKIRKSIGAAAPS----NSIQATHDIQNDMGEG 548

Human   478 YNGNDVNFQDTSDE---SSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDS--SAAQRGHS 537
            ..|.:....|..:|   :.|||.|||........|.|..||         .||:|  |....|.:
  Fly   549 SGGGEGQIGDDEEEYGGAHGSGDGSGDGPHTPIEESEGTTT---------NEVESRDSGKTSGSN 604

Human   538 LL----SWSLTCIVLALQRLC 554
            .|    :|.|..:|..|...|
  Fly   605 PLEGTATWMLLTLVTMLFSSC 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GPC6	NP_005699.1	Glypican	22..548	CDD:307347	140/598 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	348..376		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..501		8/23 (35%)
dally	NP_001246685.1	Glypican	51..622	CDD:279494	141/601 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3821
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810