Protein Alignment ATP9A and ATP8B

DIOPT Version :9

• Sequence 1: NP_006036.1
• Gene: ATP9A / 10079
• HGNCID: 13540
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Alignment Length: 1387
• Identity: 336/1387 - (24%)
• Similarity: 534/1387 - (38%)
• Gaps: 437/1387 - (31%)

Human    52 RYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVT 116
            :|..|.|...||:.|||||..|..||:...|.|||.|...|.:|.:......|..:||..||.:|
  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272

Human   117 VIREAVEEIRCYVRDKEVNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEK 181
            .:::|.::|:.::.|.:||::....|.....|:.|.|.:||||:|.::.||.|.||.:.|.|||.
  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337

Human   182 NGSCFLRTDQLDGETDWKLRLPVACTQRLPTAAD-LLQIRSYVYAEEPNIDIHNFVGTFTRE--- 242
            ||.||:.|.:|||||:.|.:..:..|..|....| |......:..|.||..::.|.||....
  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQR 402

Human   243 ---DSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLT 304
               |::..:.....:.||.|.         .|||::.|.:.:.:.|:...:.|....|   ..|.
  Fly   403 FALDNEKILLRGCVLRNTQWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVD---RLLN 455

Human   305 KILFGALVVVSLVMVAL--------------QHFAGRWYL---------------QIIRFLLLFS 340
            .|:.|  :|:.||.:..              |||  :.||               .:|..|:.||
  Fly   456 FIIIG--IVLFLVSICALFAIGCAIWEGLIGQHF--QLYLPWEHIIPKDYIPTGATVIGLLVFFS 516

Human   341 ------NIIPISLRVNLDMGKIVYSWVIRRDSKI--PGT----VVRSSTIPEQLGRISYLLTDKT 393
                  .::||||.|::::.:.|.|::|..|.::  |.|    ..|::|:.|:||:|.|:.:|||
  Fly   517 YAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKT 581

Human   394 GTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQ-------------------------- 432
            ||||||.|.|.:..:...:|| |.:|.....:..|..||
  Fly   582 GTLTQNIMTFNKCSINGRSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAP 645

Human   433 ---------------------------------------------------------------SQ 434
                                                                           ||
  Fly   646 PPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ 710

Human   435 D-----------------PPA-------------------------------------------- 438
            |                 ||.
  Fly   711 DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETH 775

Human   439 -----------------QKGPTLTT----------------KVRRTMSSRVHEAVKAIALCHN-- 468
                             :|.|:..|                :...|:|:..|...::.|...|
  Fly   776 NMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS 840

Human   469 ---------------VTPVYESN------GVTDQAEAEKQYE------------------DSCRV 494
                           ..|.:||:      .:.|...:::::.                  |....
  Fly   841 SSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLE 905

Human   495 YQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDES 559
            |||.||||.|||....:.|.....|..:|:.:...| |...:.:|.|..|....|||.:|:|...
  Fly   906 YQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMG-QTEEYELLNILDFNNVRKRMSVILRRGD 969

Human   560 TGEITFYMKGADVVM-----AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYV 619
            :  :..|.||||.|:     .|........::.....|.||||.|.:|::.|.|:.|.|:.:|..
  Fly   970 S--MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQ 1032

Human   620 QAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETA 684
            :|.||:..|..|:..:.|.:|.||:|:.:|.:||:||..|..::..|:|||||:|:|||||.|||
  Fly  1033 EAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETA 1097

Human   685 TCTAKNAHLVTRNQDIHVFRLVTNR-GEAHLELNAFRR--------------------------- 721
            .....:..|:| ::...||.:..|. .|...:|..|:.
  Fly  1098 INIGYSCQLLT-DELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDP 1161

Human   722 ----------------------------------------------KHDC--------------- 725
                                                          ..:|
  Fly  1162 LSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGT 1226

Human   726 -----------ALVISGDSLEVCLK-YYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGK 778
                       |||::|.||..||. ..|.:|:::|.||.||:|||..|.|||.:|.|::.....
  Fly  1227 ASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNA 1291

Human   779 LTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALS 843
            :|.|:|||.||||||:.:..|||:.|:||.||.|::|:||.||::|.|||:||||.||.|.....
  Fly  1292 VTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFL 1356

Human   844 QFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSL-VLDKDVKSEVAMLYP 907
            ::..:::...:.....:|....|::..::....|..|:..||..||.:| |.::||..:.::.:|
  Fly  1357 RYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFP 1421

Human   908 ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGA---LLLF-----------------ESEFVH 952
            .||...||....:.:.|       ||   ::::||   |:||                 .|:.:.
  Fly  1422 RLYTPGLKSELFNIREF-------IY---SVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMT 1476

Human   953 IVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLS------ 1011
            :.|:..|.||:.....::|....|..:..|....||..|.....|.:..|...::.:|:
  Fly  1477 LGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLTQAMKDL 1541

Human  1012 FLWKVSVITLVSCL-PLYVLKY 1032
            ..|...:||:::.: |:...|:
  Fly  1542 TFWVTMLITVMALVAPVLAYKF 1563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP9A	NP_006036.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	321/1310 (25%)
		Cation_ATPase	464..571	CDD:404183	33/147 (22%)
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	20/51 (39%)
		Cation_ATPase	891..985	CDD:289987	30/96 (31%)
		HAD_like	<1261..1324	CDD:304363	32/62 (52%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	61/250 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930