DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRU and Ptp36E

DIOPT Version :9

Sequence 1:	XP_016855481.1	Gene:	PTPRU / 10076	HGNCID:	9683	Length:	1452	Species:	Homo sapiens
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	187/565 - (33%)
Similarity:	304/565 - (53%)	Gaps:	35/565 - (6%)

- Green bases have known domain annotations that are detailed below.

Human   907 ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANYIDIRINREGYHRSNHFIATQGPK 971
            |.||.:..|....:.:| ||.:||.|..:.|..::||:||:|:|..:      :.|.:|.||||.
  Fly   120 ALKKNNLEKNQNPKCIP-YDYNRVVLEKVGGLQDSDYVNASYVDSLL------KPNAYIVTQGPV 177

Human   972 PEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWP---EDSDTYGDIKIMLVKTETLAEYVV 1033
            .|.|..:|||||||:.|:|||:||..:..:|.|.:|||   |..:.||||.|.:|:.|.||.:.:
  Fly   178 EETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHI 242

Human  1034 RTFAL----ERRGYSARHEVRQFHFTAWPEHGVPYHATGLLAFIRRVK-------ASTPPDAGPI 1087
            |||.|    |::..:....:.|||:|.|..|..|: :..||.|.|||:       .......|||
  Fly   243 RTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDEDDMRGPI 306

Human  1088 VIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACL 1152
            ::|||.|.||:|.|:.:|..|::||.|...:::..:|.|...|..:::..|||.||:|.:.|..:
  Fly   307 LVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHII 371

Human  1153 CGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMD 1217
            ||:|..||||.....|...|.:..:..::.:.|:..:...||...:.:|:......||:|||.:.
  Fly   372 CGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVL 436

Human  1218 VLPPDRCLPFLISTDGDS-NNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVM 1281
            .:|||...|:|.|..|:: .:|||:...|.||:...:|||..|::.|..:||.||||..|:::|:
  Fly   437 CVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVV 501

Human  1282 LNQLNQSNSAWPCLQYWPEPGR-QQYG-LMEVEFMSGTADEDLVARVFRVQ----NISRLQEG-- 1338
            |.|....:..:|  .:||...: ::|| :..|.::...:..::....|::.    :::.:..|
  Fly   502 LCQPPSQSQQYP--SFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVK 564

Human  1339 --HLLVRHFQFLRWSAYRDTPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1401
              ...|:.||...|......|.|..:.::|:..|:.|:.:...|...|...:|..|:|.:||...
  Fly   565 APTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANA 629

Human  1402 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1446
            .:|.:..|..||||.|.||:|.::|.:||.|.:|.:|||:.|.|:
  Fly   630 CIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRU	XP_016855481.1	None
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	93/250 (37%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053	75/244 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20096at33208
OrthoFinder	1	1.000	-	-		FOG0000829
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.780