|
Human 6 TKLKKTPTE-APADCRALIDKLKVCNDEQLLLELQQIKTWNIGKCELYHWVDLLDRFDGILADAG 69
|:.:|...| ..|..:.|:|.|..|:....|..::.|:.|:..:.:||.|:.:|||.||:|....
Yeast 5 TRCEKARKEKLAAGYKPLVDYLIDCDTPTFLERIEAIQEWDRSRDDLYVWIPILDRMDGLLLKVA 69
Human 70 QTVENMSWMLVCDRPERE-QLKML---------LLAVLNFTALLIEYSFSRHLYSSIEHLTTLLA 124
:..:.. ..|::| ::|:: .|.:|.||..|:..:.:|.:|||.:.|..||.
Yeast 70 EKYKYK------QDPKKECEVKLVEMEAHDVDYCLKMLKFTRRLLLNTENRFVYSSGDVLMYLLN 128
Human 125 SSDMQVVLAVLNLLYVFSKRSNYITR--------LGSDKRTPLLTRLQHLAESWGGKENG--FGL 179
..:..:.|||:.:|.:..:|. .|.| .|.........:|.....|....|:| |.|
Yeast 129 CPNFTIKLAVMRILAILGERF-VIAREKIVAHNIFGDHNLRKKTLKLALSLSSSVMDEDGEHFSL 192
Human 180 AECCRDLHMMKYPPSATTLHFEFYADPGAEVKIEKRTTSNTLHYIHIEQLDKISESPSEIME-SL 243
.:...| ..|.|.....|.|..|.....:...:::...|... ..:.|::.:..|:.| ||
Yeast 193 VDLYFD--KKKVPQKWRKLRFTHYTSNDFKKSSQQKNNINETQ----TSIKKVTMTTQELCEHSL 251
Human 244 TKMYSIPKDKQMLLF---------THIRLAHGFS-----NHRKRLQAVQARLHAISIL-VFVSPF 293
.::: ||.|.|. ....:|..|| |...|...::.:|:||:.: ...||.
Yeast 252 QQIF----DKGMALLPAESWFDFSIKASVAKAFSDDSGENIDLRNIIIETKLNAIAFVNTIFSPP 312
Human 294 AVYSNALQESANSILYNGLIEELVDVLQITDKQL-MEIKAASLRTL--TSIVHLERTPKLSSIID 355
.|.|...: .:...:| .|.|::.:::.:: .|::..:|.|| .|:.|: ..|.||.
Yeast 313 QVSSKLFE--LDPYAFN----SLTDLISLSETKIPKELRTDALFTLECISLKHV----WCSDIIR 367
Human 356 CTGTASYHGFLPVLVRNCIQAMIDPSMDPYPHQFATALFSFLYHLASYDAGGEALVSCGMMEALL 420
..|....||.|..::| .|...:..:.|....::....|..:.:||......|:|.:.|::..||
Yeast 368 NLGGNISHGLLFQILR-YIAKTLREATDEIDEEYNVRFFYLISNLADVKPLHESLFAAGLIPTLL 431
Human 421 KVIKFLGDEQDQI---------TFVTRAVRVVDLITNLDMAAFQSHSGLSIFIYRLEHEVDLCRK 476
:::........:. ||:..:....:.|.| .|.::.|..:.:|:|.
Yeast 432 EIVSIRNCPYKRTLASATHLLETFIDNSETTTEFIEN---------DGFTMLITSVANEIDF--- 484
Human 477 ECPFVIKPKIQRPNTTQEGEEMETDMDVADVAMESSPGSSI---SMEHRLDVELRASGSSSSTNI 538
.:..|.|.| .|..|: |:..| ||
Yeast 485 --------TLAHPETWQ------------------PPKYSVVYYSISFR---EL----------- 509
Human 539 SSGPSPGPSPGPGTGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPGPRPGVQCIPQRAALLKSMLN 603
|.::|:|.
Yeast 510 ---------------------------------------------------------AYIRSLLK 517
Human 604 FLKKAIQDPAFSDGIRHVMDGSLPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQD 668
.:.|.:...: .|.||:::|..:..|||.|:.|...:|.:|.....:||...:..||::...|.:
Yeast 518 LVLKLLSTDS-GDRIRNLIDSPILVSLKKILENKLVFGLTLITYTLDVVQKVINSEPTIYPVLVE 581
Human 669 NGLTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAM 733
.||...::.. ..|.:..:.|:|..||:|.||:|||..||:...:......||..||..|:...:
Yeast 582 AGLIPYVIDN-FPKLIGPSAELLSLLPDVVSAICLNPEGLKQVKEKGLINNLFDFLLDADHARIL 645
Human 734 RRRRSSDPLGDTASNLGSAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDPKYICQKPSIQKAD 798
.. ||.::..|:.:|||.||.|.||.: ::|.:||: |.:.||..:.:
Yeast 646 TG-------GDRSTEYGTDIDELARHYPDLKAN-------IVEALCNV------IRKMPSTFRNE 690
Human 799 GTATAPPPRSN----HAAEEASSEDEEEEEVQAMQSFNSTQQNETEPNQQVVGTEERIPIPLMDY 859
.......|:.. |...|....|:||.|....:..:. || ::|.
Yeast 691 REFLFTSPKDQKYFFHRKNEEILTDKEEHEPAYWELLDK-------------GT-------MLDT 735
Human 860 ILNVMKFVESILSNNTTDDHCQEFVNQKGLLPLVTILGLPNLPIDFPTSAACQAVAGVCKSILTL 924
..:|: |..|: .|.:.....:.:..:..| .|:.:.|.|.::.||.|...|..|.: .|..
Yeast 736 FTSVL-FGMSL--GNGSFSQVPQHLEARDFL---AIIFMENPPYEYFTSVAISNVTEVLQ-YLDE 793
Human 925 SHEP-------KVLQEGLLQLDSILSSLEPLHRPIESPGGSVLLRELACAGNVADATLSAQATPL 982
.:|. |||.:.|..|:..|:|.......:|..|.:.: .:|...: .:...:
Yeast 794 KYEDYAFMDVMKVLNDQLENLNDFLNSPNDRSFFLERDGENSV---RSCHSKL------CRLAAI 849
Human 983 LHALTAAHAYIMMFVHTCRVGQSEIRSISVNQWGSQLGLSVLSKLSQLY--CSLVWESTVLLSLC 1045
|:.:| :.||.:...:|: |.:.:..:..:.|.|::..|..|: |:| ..:.:...
Yeast 850 LNIVT--NVYIDLTTLSCK------RIMQIYSYFDKRGFSLIKNLKLLFQKCAL---EEMYIRQH 903
Human 1046 TPNSLPSGCEFGQADMQKLVPKDEKAGTTQGGKRSDGEQDGAAGSMDASTQGLLEGIGLDGDTLA 1110
.|:|: :.:.:| |..:.:.||. .
Yeast 904 MPDSV----------ITETMP--------------------------------LPIVDVSGDG-P 925
Human 1111 PME--TDEPTASDSKGKSKITPAMAARIKQIKPLLSASSRLGRALAELFGLLVKLCVGSPVRQRR 1173
|:: .|:|...|.|| |||........|::.:|.. |....|.||...::| |..|...
Yeast 926 PLQIYIDDPKKGDQKG--KITSVKTRNTLQMRTILYT---LQSNTAILFRCFLRL---SHSRNMD 982
Human 1174 SHHAASTTTAP--TPAARSTASALTKLLTKGLSWQPPPYTPTPRFRLTF--FICSVGFTSPMLFD 1234
..|...||... .....:....|.....:| :.|.....|.| |:.::...||...:
Yeast 983 LEHKDLTTEVHIFENVVENVIEMLKATELEG-------HLPYILVLLNFNTFVFTIPKASPNSTE 1040
Human 1235 -ERKYPYHLMLQKFLCSGGHNALFETFNWALSMGGKVPVSEGLEHSDLPDGTGEFLDAWLMLVEK 1298
.:..|.::..|| ||:...........:...|:.....|::.:..|.:. .::.:..
Yeast 1041 ILQTIPAYIFYQK----GGYLLYLHIIRDLFTRMTKIKDLSSLDNINYIDESN-----GILTLSC 1096
Human 1299 MVNPTTVLESPHSLPAKLPGGVQNFPQFSALRFLVVTQKAAFTCIKNLWNRKPLKVYGGRMAESM 1363
::|..|.... |:..:....||:..:: .|:....:..:|.| ..|:|| ||
Yeast 1097 LINALTFYNK--SMQTETMENVQSIGKY------YVSIDDDYNIMKAL--TVPIKV----MA--- 1144
Human 1364 LAILCHILRGEPVIRERLSKEKEGSRGEEDTGQEEGGSRREPQVNQQQLQQLMDMGFTREHAMEA 1428
||::..:.:.:.:.:.: ||..|....:||..::...||.
Yeast 1145 LAMILDLDKSDSLFKTQ--------------------SRNVPYSVFKQLLSMLKNIFTN------ 1183
Human 1429 LLNTSTME-QATEYLLTHPPPIMGGVVRDLSMSEEDQMMRAIAMS----LGQDIPMDQRAE--SP 1486
:|..|.| ....:.|..|| ::.:|:.|:..:...:|.: .|.|:|.|.... ||
Yeast 1184 -VNIYTKELYELHWDLIFPP------IKKISLFEQVGIPGDVAANYLTDTGDDLPADNSIGLFSP 1241
Human 1487 EEVACRKE--EEERKAREKQEEEEAKCLEKFQDADPLEQDELHTFTDTMLPGCFHLLDELPDTVY 1549
|:....|: .|::.....|..: .:.::.....|.|||. ||... |.||..::
Yeast 1242 EQWEKYKKLIGEDKSIYYPQPMQ----AQYYKGCSSKELDELR---DTFFN------DGLPSRIF 1293
Human 1550 RVCDL---IMTAIKRNGADYRDMILKQVVNQVWEAADVLIKAALPLTTSDTKTVSEWISQMATLP 1611
.|... ::.|..:. |.|:..:..|..:|.
Yeast 1294 TVLPFYPKLVNAFAKT--------LLQIFTKYDEPTEVF-------------------------- 1324
Human 1612 QASNLATRILLLTLLFEELKLPCAWVVESSGILNVLIKLLEVVQPCLQAAKEQKEVQTPKWITPV 1676
|..:..|||...| :....|:.||.|..: ....|:|
Yeast 1325 -AGRILDRILETDL-------------DDPATLSSLIHLFGI-------------FLNEKYI--- 1359
Human 1677 LLLIDFYEKTAISSKRRAQ-MTKYLQSNSNNWRWFDDRSGRWCSYSASNNSTIDSAWKSGETSVR 1740
|:|.:...:|..: :.|.|:....|..||
Yeast 1360 ------YQKASHLMQRFIEYLEKSLKPEHVNTPWF------------------------------ 1388
Human 1741 FTAGRRRYTVQFTTMVQVNEETGNRRPVMLTLLRVPRLNKNSKNSNGQELEKTLEESKEMDIKRK 1805
.:..|..: ::|....:|.|.:.|| |:..:
Yeast 1389 ---SKALYVYE----------------IILAKSELPHLEELSK-----------------DVLLR 1417
Human 1806 ENKGNDTPLALESTNTEKETSLEETKIGEILIQGLTEDMVTVLIRACVSMLGVPVDPDTLH---A 1867
.|| |...|:..| ...:.:.:..:|||.. |....: |
Yeast 1418 ------YPL------------LSMAKVFRI-PDPMKQKLFDILIRVS--------DISNFYSALA 1455
Human 1868 TLRLCLRLTRDHKYAMMFAE----LKSTRMILNLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTM 1928
|.|:.:..:||..||...|. .:..::|.:..:....|.......||.|...| ....:
Yeast 1456 TSRILIFYSRDELYANNIARSGILSRLLKVIGSFQKLDKINFLESSFLLLTRRCFE----TTENV 1516
Human 1929 EKVVRSAATSGAGSTTSGVVSGSLGSREINYILRVLGPAACRNPDIFTEVANCCIRIALPAPRGS 1993
:.::| |......|...:..|....||:..||........|:|..|.:| .|
Yeast 1517 DALIR--AEINRSFTARPLGGGDDAVRELTTILEEKAHVVMRSPSQFIDV--LC----------- 1566
Human 1994 GTASDDEFENLRIKGPNAVQLVKTTPLKPSPLPVIPDTIKEVIYDMLNALAAYHAPEEADKSDPK 2058
.||...||: |....|.|.:...|. |.||:
Yeast 1567 ETARFHEFD---------------------------DQGALVDYSLKRFLG------EKDKN--- 1595
Human 2059 PGVMTQEVGQLLQDMGDDVYQQYRSLTRQSSDFDTQSGFS--INSQVFAADGASTETSASGTSQG 2121
|| :.:.:.||...::|.. :.||:.|| :.:.
Yeast 1596 ----TQ------------------ASSTEKSDIYERTGIMHLLLSQLMAA-----------SEKD 1627
Human 2122 EASTPEESRDGKKDKEGDRASEEGKQKGKGSKPLMPTST-ILRLLAELVRSYVGIATLIANYSYT 2185
..|.|..|.|..::|:. |......|:..... :|:||.|||.||.........:|..
Yeast 1628 WLSEPANSSDLPENKKA--------QLDPSRNPVCAYMIFLLKLLVELVSSYNQCKFEFLTFSRR 1684
Human 2186 VGQSELIKEDCSVLAFVLDHLLPHTQNAEDKDTPALARLFLASLAAA-------------GSGTD 2237
...:|..:...:.:.|.|..||......:.....|..|..:..||.: .:.||
Yeast 1685 NTYAERPRPRTTAINFFLYRLLDKPVGTDHDKHEAKRREVIGMLARSVIIGFLATVQDDRTTKTD 1749
Human 2238 AQVA--LVNEVK----AALGRALAMAESTEK-----HARLQAVMCIISTIMESCPSTSSFYSSAT 2291
.::| .:|.:: .|:.:|:..|.|:.| |.:|.....|| ||..|..|.
Yeast 1750 VKLADPHMNFIRKFAIEAIIKAIRNATSSSKLLESNHLKLDMWFRII---------TSMVYVQAP 1805
Human 2292 AKTQHNGMNNI-------IRLFLKKGLVNDLARVPHSLDLSSPNMANTVNAALKPLETLSRIVNQ 2349
...|....|.: .:|.:..||.:.:.....|:||:.|......|.|::.|.|:|...|.
Yeast 1806 YLRQLLDSNKVEADQYQLCKLVIDLGLPSVITEAMASIDLNYPFSKKIFNVAVEALNTISSTRNN 1870
Human 2350 PSSLFGSKSASSKNKSEQDAQGASQDSSSNQQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAE 2414
.|..| :.||||..:.|| .|::
Yeast 1871 FSEHF-------------------------------------KIEDHDEVEDEV-------DESD 1891
Human 2415 TDSVVIAGQPEVLSSQEMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSN 2479
.:.: |::..:..:.: .::|| :|.|.....|.| |:|
Yeast 1892 KEEI-----PDMFKNSALGM-YDVED-----IEEDDDDDTSLI-----GDD-------------- 1926
Human 2480 LSQASTLQANREDSMNILDPED--EEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGE 2542
|:|..:|.:: |...:.|:|..| .||.||::.:.||.|...|......:|.
Yeast 1927 ------------DAMAFVDSDNGFEVVFSDEDDDMG-EEDADDARSDSEENELSSEMQSSTADGT 1978
Human 2543 EGD-EDDDDDGSEMELDEDYPDMNASPLVRFERFDREDDLIIEFDNMFSSATDIPPSPGNIPTTH 2606
:.| |.||.||..:.:|:...| |:.:.::|
Yeast 1979 DVDYEVDDADGLIINIDQPSGD---------------DEEMADYD-------------------- 2008
Human 2607 PLMVRHADHSSLTLGSGSSTTRLTQGIGRSQRTLRQLTANTGHTIHVHYPGNRQPNPPLILQRLL 2671
||..|:.|.....:
Yeast 2009 --------------------------------------ANISHSSHSENEDD------------- 2022
Human 2672 GPSAAADILQLSSSLPLQSRGRARLLVGNDDVHIIARSDDEL-------LDDFFHDQSTATSQAG 2729
|:.|:::: .|||| |.|:..|:|...|...
Yeast 2023 ---ASMDVIEV--------------------------YDDELSSGYDVDLSDYDVDESDWDSGLS 2058
Human 2730 TLSSIPTALTRWTEECKVLDAESMHDCVSVVKVSIVNHLEFLRDEELEERR--EKRRKQLAEEET 2792
:|| :.|.:| |...||.:...| :.||:.|..|..
Yeast 2059 SLS--------------ISDEDS----------------ESSEDEPINSTRMGDSRRRWLIAEGV 2093
Human 2793 KITD--KGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTL 2855
::|| :|:.::::|..........||::.............::..:.:.|...::.|..:|..|
Yeast 2094 ELTDDSQGESEEDDRGVFRGIEHIFSNENEPLFRVHDEMRHRNHHRSINRTHFHSAMSAPSLSLL 2158
Human 2856 ------QSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQME 2914
||:...|..|| .|.:|..::.......||. :|| .:..:.
Yeast 2159 NRGRRNQSNLINPLGPT--GLEQVENDISDQVTVAGSG--------------SRP----RSHHLH 2203
Human 2915 LSPAPTITSLSPERAEDSDALTAVSSQ---LEGSPMDTSSLASCTLEEAVG---------DTSAA 2967
.|......|...|...|...|.:..|: :.....|:.:.|:|.:...:. .....
Yeast 2204 FSEVLVSGSFFDEPVLDGIILKSTVSRWKDIFDMFYDSKTYANCIIPTVINRLYKVSLALQKDLE 2268
Human 2968 GSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRG 3032
...||.:..:.. ....|.:..|..|.::....:|. ..||:.|.|.
Yeast 2269 NKREQEKLKNKN-----LLFNEAKVESHNSSDAISVEQDD----IQESNVTHDD----------- 2313
Human 3033 ILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPA 3097
.||:..|....|..:.|.. :||.|:.|||||||.:|....:
Yeast 2314 --HEPVYVTIQGSEVDIGGTD----IDPEFMNALPDDIRADVFAQHV------------------ 2354
Human 3098 VVGNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQRRELAQNASSDTPMDPVTFIQTLPSDLRRS 3162
.|..|:.|........::...|| |::.:|.|:|..
Yeast 2355 -----------------------RERRAEARLNSDHNVHSREIDSD-------FLEAIPEDIREG 2389
Human 3163 VLEDMEDSVLAVMPPDIAAEAQALRREQEARQRQLMHERLFGHSSTSALSAILRSPAFTSRLSGN 3227
:| |..||.| |:||...:|| .::|: :
Yeast 2390 IL-------------DTEAEEQ----------------RMFGRIGSSA--DVIRA---------D 2414
Human 3228 RGVQYTRLAVQRGGTFQMGGSSSHNRPSGSNVDTLLRLRGRL----LLDHEALSCLLVLLFVDEP 3288
..|......|:.| ...|.|:..| |.|...:...|: |:|...::.|:..:|:.:|
Yeast 2415 DDVSNNDEEVENG--LDHGNSNDRN-----NADPEKKKPARIYFAPLIDRAGIASLMKSVFISKP 2472
Human 3289 KLNTSRLHRVLRNLCYHAQTRHWVIRSLLSILQRSSESELCIETPKLTTSEEKGKKSSKSCGSSS 3353
.:.....|.:...||...|.|:.::.:.|.|| ||..|:.
Yeast 2473 YIQREIYHELFYRLCSSKQNRNDLMNTFLFIL-----SEGIIDQ--------------------- 2511
Human 3354 HENRPLDLLHKMESKSSNQLSWLSVSMDAALGCRTNIFQIQRSGGRKHTEKHASGGSTVHIHPQA 3418
|.:|.. .||...:..|..|.|
Yeast 2512 ---------HSLEKV-------------------YNIISSRAMGHAKTT---------------- 2532
Human 3419 APVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDRERGNKACSPCSSQSSSSGICTDFWD--- 3480
|:.|| ||. |:|.:..:.:..|.....|
Yeast 2533 ----------TVRQL----PSD---------------------CTPLTVANQTIEILQSLIDADS 2562
Human 3481 -----LLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLT 3540
|:.:.||:.|::....|.| |..|......||..|.::|...:|...|:|.
Yeast 2563 RLKYFLIAEHDNLIVNKANNKSRK----------EALPDKKLRWPLWHLFSLLDRKLITDESVLM 2617
Human 3541 EKLLRLLSLISIALPENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAP 3605
:.|.|:|.:
Yeast 2618 DLLTRILQV-------------------------------------------------------- 2626
Human 3606 ALVAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQ 3670
.|.|:::..|:...|. :.|..|.:.| ..|:.
Yeast 2627 ------------------------CTKTLAVLSTSSNGKE--------NLSKKFHLPS--FDEDD 2657
Human 3671 LQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGT----- 3730
|...:.::...||:....:...|::..||: |.| |..|.|
Yeast 2658 LMKILSIIMLDSCTTRVFQQTLNIIYNLSK-------------LQG--------CMSIFTKHLVS 2701
Human 3731 ----LLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLG 3791
::::|:. :.|||..|....|.
Yeast 2702 LAISIMSKLKS--------------ALDGLSREVGTITT-------------------------- 2726
Human 3792 GRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVR 3856
|.|:....:...|..:|.|...|::|..: |....:|:
Yeast 2727 GMEINSELLQKFTLPSSDQAKLLKILTTV-----DFLYTHKR----------------------- 2763
Human 3857 QLEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPSAQDTQSIASDGTP 3921
Yeast 2764 ----------------------------------------------------------------- 2763
Human 3922 QGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHD-QHAVLVLQPAVEAFFLVHATERE 3985
||:|....:|..|.::::...:|..|.|||.:.|:|.. ..:..:|.|.:|:..:|
Yeast 2764 ---KEEERNVKDLQSLYDKMNGGPVWSSLSECLSQFEKSQAINTSATILLPLIESLMVV------ 2819
Human 3986 SKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE 4050
.|.|.|:..::.......|.|...:.:.:: ..|..|.:
Yeast 2820 -------CRRSDLSQNRNTAVKYEDAKLLDFSKTRVE--------------------NLFFPFTD 2857
Human 4051 THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDH 4115
.|:.:|||::| |...|..||||:||...:|||||.||.:|..:|: .:...:..:.:.|||:.
Yeast 2858 AHKKLLNQMIR-SNPKLMSGPFALLVKNPKVLDFDNKRYFFNAKLK--SDNQERPKLPITVRREQ 2919
Human 4116 VFEDSYRELHRKSPEEMKN-RLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRV 4179
||.||||.|..|:.:|:|| :|.|.|:||.|.||||:.||||.::||:||||.||||...|.|:.
Yeast 2920 VFLDSYRALFFKTNDEIKNSKLEITFKGESGVDAGGVTREWYQVLSRQMFNPDYALFLPVPSDKT 2984
Human 4180 TYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFY 4244
|:..|.:|..||.|||:|||:|.|:.||:.|...|:|:|:|..||:|||:.|...||||.|..:|
Yeast 2985 TFHPNRTSGINPEHLSFFKFIGMIIGKAIRDQCFLDCHFSREVYKNILGRPVSLKDMESLDPDYY 3049
Human 4245 QGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAI 4309
:.||::||||::.: .:.|||.|..::|..:|.:|...|.:|:|||.||::||..|.:.::..::
Yeast 3050 KSLVWILENDITDI-IEETFSVETDDYGEHKVINLIEGGKDIIVTEANKQDYVKKVVEYKLQTSV 3113
Human 4310 RKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRA 4374
::|:..||.|||.:|.|.||:||.||||||||||||.||:||.|:||.|..|.:...::.:||||
Yeast 3114 KEQMDNFLVGFYALISKDLITIFDEQELELLISGLPDIDVDDWKNNTTYVNYTATCKEVSYFWRA 3178
Human 4375 LRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPA 4439
:||||..:|||.||||||||||||.||..|.|:||:.||.||||..|::||||:|||||||:||.
Yeast 3179 VRSFDAEERAKLLQFVTGTSKVPLNGFKELSGVNGVCKFSIHRDFGSSERLPSSHTCFNQLNLPP 3243
Human 4440 YESFEKLRHMLLLAIQECSEGFGLA 4464
|||:|.||..|||||.|..||||||
Yeast 3244 YESYETLRGSLLLAINEGHEGFGLA 3268
| 
