Protein Alignment HUWE1 and Nedd4

DIOPT Version :10

• Sequence 1: XP_016884687.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4464
• Species: Homo sapiens
• Sequence 2: NP_648993.1
• Gene: Nedd4 / 39958
• FlyBaseID: FBgn0259174
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 999
• Identity: 297/999 - (29%)
• Similarity: 424/999 - (42%)
• Gaps: 211/999 - (21%)

Human  3513 PYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPENK-VSEAQANSGSGASSTTTA 3576
            |...|...:|:....| .|  |||.....::...|.:....:.|.: .||..:.:..|......|
  Fly   166 PTEQEGRTIGEQSYTL-RP--RRSVGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEA 227

Human  3577 TSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVAASTTVTTPTTATTTVSISPTTK 3641
            |:        |..|:..|  .|.|.....||.|..  .....|...|.....||.||....||..
  Fly   228 TN--------AGETSAQP--HPFPTGGHDALPAGW--EERQDANGRTYYVNHTARTTQWDRPTVL 280

Human  3642 GSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTS----HSCSEEGLEDAANVLLQLSRGD 3702
            .|.|        |.|||.::.|.  .:.:..:||:...|    .|.|...:||.
  Fly   281 NSHS--------SQSTDDQLASD--FQRRFHISVDDTESGRSADSISHNSIEDN----------- 324

Human  3703 SGTRDTVLKLLLNGARHLGYTLCKQIGT-------------LLAELREYNLEQQRRAQCETLSPD 3754
                        |.|..|.|| .|...|             :||:     :..|.||:
  Fly   325 ------------NNAAGLAYT-PKTAATSSAPPNTPTNNNGILAQ-----IAMQYRAE------- 364

Human  3755 GLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTSTQKFFLRVLQV 3819
               |:|..|            :.....:..|.:.|:..|:.::       |.||.|.....|.:.
  Fly   365 ---EDQDPT------------VDHTSFVYNSLRHPVAHRQPEI-------SATSLQNDLRPVREA 407

Human  3820 -----IIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAV-----RQLEAEADAIIQMV----- 3869
                 |......||||  .....|..|.........:|..:     ||.:.:.:.|:..|
  Fly   408 PGVPDIAITNPFTRRA--AGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQ 470

Human  3870 ---REGQRARRQQQAATSESSQSEASVRREESPMDVDQPSP---SAQDTQSIASDGTPQGEK--- 3925
               ..|||.::|.:.:..::..:::     .:|.|:..||.   |.:|..::     |..|:
  Fly   471 EPQHRGQRHQQQHRPSNEDTDHTDS-----HNPSDISAPSTRRNSEEDNAAV-----PPMEQNTG 525

Human  3926 -EKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLVLQPAVEAFFLVHATERESKPP 3989
             |:|..||.             |.|                  .:.|....||:.||:.|.:...
  Fly   526 GEEEPLPPR-------------WSM------------------QVAPNGRTFFIDHASRRTTWID 559

Human  3990 VRDTRES----QLAHIKDEPPPLSPAPLTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAE 4050
            .|:.|.|    |...::|:..||         |...:.....:....:|..:.
  Fly   560 PRNGRASPMPNQTRRVEDDLGPL---------PEGWEERVHTDGRVFYIDHNT------------ 603

Human  4051 THRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVRRDH 4115
              ||...:..|.|..::|    ...|.|.|  |:..|.:||:..:.:......|  ..:.:||..
  Fly   604 --RTTQWEDPRLSNPNIA----GQAVPYSR--DYKQKYEYFKSHIRKPTNVPNK--FEIRIRRTS 658

Human  4116 VFEDSYRELHRKSPEE-MKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRV 4179
            :.|||||.:...:..: :|.:|::.||||.|.|.|||.|||:.::|:|||||.|.||..|..|..
  Fly   659 ILEDSYRIISSVTKTDLLKTKLWVEFEGETGLDYGGLAREWFYLLSKEMFNPYYGLFEYSAMDNY 723

Human  4180 TYTINPSSH-CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHF 4243
            |..||..|. ||..|||||||:|||...|||..:||:.:|.|.|||.:|.|.:...||||.|..:
  Fly   724 TLQINNGSGLCNEEHLSYFKFIGRIAGMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEY 788

Human  4244 YQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGA 4308
            |..|:::.|||...|  :|||..:...||.....:|||.||||.||.|||.||:.||.:.|....
  Fly   789 YNSLMWIKENDPRIL--ELTFCLDEDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVAR 851

Human  4309 IRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFW 4372
            :::|:::||:||..|||..||.||.|.|||||:.|:..||:.|.:.||.|. .|..|.|.|||||
  Fly   852 VKEQMSSFLDGFGSIIPLNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIIIQWFW 916

Human  4373 RALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDL 4437
            ||:.||....|::.||||||||:||:.||..|.|.||.|.|.|.:.. :.:..|.||||||:|||
  Fly   917 RAVLSFSNEMRSRLLQFVTGTSRVPMNGFKELYGSNGPQMFTIEKWG-TPNNFPRAHTCFNRLDL 980

Human  4438 PAYESFEKLRHMLLLAIQECSEGF 4461
            |.||.:.:|:..|:.|| |.|:||
  Fly   981 PPYEGYLQLKDKLIKAI-EGSQGF 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	XP_016884687.1	DUF908	92..374	CDD:428721
		DUF913	438..904	CDD:461803
		UBA_HUWE1	1407..1446	CDD:270474
		WWE	1707..1768	CDD:460715
		PHA03247	<2825..3156	CDD:223021
		UBM	3100..3133	CDD:464159
		HECTc	4109..4462	CDD:238033	171/356 (48%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999	9/40 (23%)
		WW	248..277	CDD:459800	8/30 (27%)
		HUL4	<523..1003	CDD:227354	203/545 (37%)