Protein Alignment HUWE1 and CG5087

DIOPT Version :10

• Sequence 1: XP_016884687.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4464
• Species: Homo sapiens
• Sequence 2: NP_648279.1
• Gene: CG5087 / 39035
• FlyBaseID: FBgn0035953
• Length: 1078
• Species: Drosophila melanogaster
• Alignment Length: 989
• Identity: 236/989 - (23%)
• Similarity: 376/989 - (38%)
• Gaps: 259/989 - (26%)

Human  3607 LVAATAISTIVVAASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQL 3671
            |:..|....:.|...|.|     |..|:.:.|...|:.|.             .:::..|:|
  Fly   218 LIRGTVREELSVKPVTLV-----AIITLCLRPLIDGNFSR-------------NLLAKFLSE--- 261

Human  3672 QLSVEVLTSH------SCSEE----GLEDAANVLLQLSRGD-----------SGTRD-----TVL 3710
            .|||..|..|      .|.|:    ||...|   |.:| ||           .||:.     .::
  Fly   262 ILSVPALIYHLQQSVPQCLEQFSSMGLLKKA---LSIS-GDVQWFEEFGTSMPGTKSLAFLGNIV 322

Human  3711 KLL-LNG---ARHLGYTLCKQIGTLLAELREYNLEQQRRAQCETLSPDGLPEEQPQTTKLKGKMQ 3771
            .|. ::|   ::.|.|.|..:..|.|.||                        .|.|...||...
  Fly   323 NLFNIDGQGESKELAYPLLTETTTSLLEL------------------------IPNTVTTKGVFT 363

Human  3772 SRFDMA------------ENVVIVASQ----------KRPLGGR-----------ELQLPSMSML 3803
            ...::.            :||.::..|          |..||..           |.|.|
  Fly   364 QWHELLGWHTPGPEPAQNQNVALIKKQFHMLWDHRCIKLLLGDLLKQINLNYERIEFQSP----- 423

Human  3804 TSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAEADAIIQM 3868
             .:.|......|.|:     |..||..|.            :|.|||.|:..:..:.::..::|:
  Fly   424 -QQPSISNLLRRALE-----RSSTRGVNL------------MGVASSKQSKQQWRKLDSAEVVQV 470

Human  3869 VREGQRARRQQQAATSESSQSEASV-----RREESPMDVDQPSPSAQDTQSIASDGTPQGEKEKE 3928
                .|......||.:..||.:..:     ..:....|:         ...|.|.|...|.||
  Fly   471 ----SRICGMYYAALNTLSQMKLDILTGICYSDNVLYDI---------WLLITSLGPNCGMKE-- 520

Human  3929 ERPPELPLLSEQLSLDE----LWDMLGECLKELEESHDQHAVLVLQPAVE-------AFFLVHAT 3982
                .|.||..:.:|.:    :..:..:|:.......|:|.:...|...:       .:||.:..
  Fly   521 ----YLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDYVLLTYFLNNIL 581

Human  3983 ERESKPPVRDTRESQLAHIKDEPPPLSPAPL----------TPATPSSLDPFFSREPSSMHISSS 4037
            .:    .:.|...:...:|...|..||...|          .|.||          |....|...
  Fly   582 YK----LINDNLLAGAKNIVQHPVFLSLHTLMLCLYRRDCRRPFTP----------PKHWLIPEV 632

Human  4038 LPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQ--ELERLDE 4100
            .|          .|....|.:..|.:...||..|        .::..:.:.|.||:  :.|:...
  Fly   633 KP----------STFINDLEKAKRNAMLLLAKMP--------HIIPHEDRVKLFRKFVQNEKAVM 679

Human  4101 GLRKEDMA------VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVF---EG--EEGQDAGGLLRE 4154
            ||.:...|      :.:.||.:.||.||:|..:..:.:|..:.:.|   :|  |.|.|..|:.:|
  Fly   680 GLTESACASPRSALIVIHRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKE 744

Human  4155 WYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFT 4219
            :.....:::|:|...||:|:...|: |. :|.|:...|||..|:||||::.||||:..:::..|.
  Fly   745 FLEETIKKVFDPSLNLFKTTSDQRL-YP-SPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFA 807

Human  4220 RSFYKHILGKSVR--YTDME---SEDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEVR 4277
            ..|...:||::.:  |:.|:   |.|...|:.|.::  .:.|||.|  :||||.:....|.....
  Fly   808 SFFLSQLLGQTQQALYSCMDELPSLDNELYRSLTFIKHYKQDVSDL--NLTFSVDQDVMGKIVTL 870

Human  4278 DLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLIS 4342
            .|.|.|...:|.:.||..|:|.:....|...||:|..||..||..|:....:|:|:..||:.|||
  Fly   871 ALHPGGKARVVNDHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLIS 935

Human  4343 G-LPTIDIDDLKSNTEYHKYQSNSIQIQ-WFWRAL-RSFDQADRAKFLQFVTGTSKVPLQGFAAL 4404
            | ...:|:.||:.:|.|:....::.|:. |.|..| :.|.:.:|..||:|||..||.||.|||.|
  Fly   936 GDTSPLDLKDLQKHTHYYGGFHDTHQVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLLGFAHL 1000

Human  4405 EGMNGIQKFQIHRDDRSTD-------------------RLPSAHTCFNQLDLPAYESFEKLRHML 4450
            |....|:..::..|:.:.|                   |||::.||||.|.||.|:....||..|
  Fly  1001 EPPFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKL 1065

Human  4451 LLAIQECSEGFGLA 4464
            ..|:.. :.||.|:
  Fly  1066 RYAVSS-NTGFELS 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	XP_016884687.1	DUF908	92..374	CDD:428721
		DUF913	438..904	CDD:461803
		UBA_HUWE1	1407..1446	CDD:270474
		WWE	1707..1768	CDD:460715
		PHA03247	<2825..3156	CDD:223021
		UBM	3100..3133	CDD:464159
		HECTc	4109..4462	CDD:238033	124/386 (32%)
CG5087	NP_648279.1	IQCD	20..50	CDD:467745
		HECTc	694..1076	CDD:238033	124/386 (32%)