Protein Alignment HUWE1 and Herc4

DIOPT Version :10

• Sequence 1: XP_016884687.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4464
• Species: Homo sapiens
• Sequence 2: NP_001261249.1
• Gene: Herc4 / 38151
• FlyBaseID: FBgn0035207
• Length: 1062
• Species: Drosophila melanogaster
• Alignment Length: 825
• Identity: 208/825 - (25%)
• Similarity: 337/825 - (40%)
• Gaps: 218/825 - (26%)

Human  3797 LPSMSM-LTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGR-----LGSSG-LGSASSIQAA 3854
            ||.|.| |...|            |.|:....|.........||     ||||| ||:.|:....
  Fly   297 LPRMVMELMGST------------ITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLM 349

Human  3855 VRQ------LEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRR-----EES---------- 3898
            :.|      :.....|::|                |..||....:|:     ::|
  Fly   350 LPQVVIGPWVSPSGSALLQ----------------SNDSQVSLVIRQIFSGGDQSIVTTTLFVDK 398

Human  3899 --PMDVDQPSPSAQDTQSIASDGTPQGEKEKEERPPELPLLSEQLSLDEL------WDMLGECLK 3955
              |.|....:|.:| ..::.::.|.|..:.|:....::.|||   |::.:      |:  |..|.
  Fly   399 VPPEDFRNYNPKSQ-ILTLTAEVTKQCAQCKQGLQSDMDLLS---SIELIFRSQACWN--GSFLL 457

Human  3956 ELEESHDQH---AV----LVLQPAVEAFFLVHATERES-KPPVRDTRESQLAHIKDEPPPLSPAP 4012
            :    ||:|   :|    |.|:.|..||..:.|.|.|| :..:.|....:|.    .....|||.
  Fly   458 D----HDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELV----GSLVCSPAD 514

Human  4013 LTPATPSSLDPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTT----HL------ 4067
            :.......|.|.:....:|.|..|...|......:.||..|.|||:.|.|:..    ||
  Fly   515 VESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLH 579

Human  4068 -------------ADGPFA--------------VLVDYIRVL----------------------D 4083
                         |..|.|              :::..::.|                      |
  Fly   580 VVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSD 644

Human  4084 F-DVKRKY--------------------FRQE----LERLDEGLR-------------------- 4103
            : ||:::|                    |.|.    |.:.|:.|:
  Fly   645 YADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGM 709

Human  4104 --KEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNP 4166
              .:.:.::|.|:::.:||.|||...|..::|..|.|.|.|||.:||||:.:|::|::.:::.:|
  Fly   710 PISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDP 774

Human  4167 MYALFRTSPGDRVTY----TINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHIL 4227
            .|.:|:.....|:.:    |....:       .|| .:|.:...|:|:..::...|..:.:|.:|
  Fly   775 KYGMFKEYEQSRLLWFADLTFETEN-------MYF-LIGVLCGLAIYNFTIINLPFPLALFKKLL 831

Human  4228 GKSVRYTDMES---EDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVT 4289
            ||.|..:|:..   .:.:..|.|:....:|...: :||||......||..|.:.|||||..|.||
  Fly   832 GKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEV-FDLTFEISRDVFGEAETKCLKPNGNEIAVT 895

Human  4290 EENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKS 4354
            .||::|:|.|........::.....||.:||.::...|:|.||..:||..::.|....|...|:.
  Fly   896 LENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQD 960

Human  4355 NTEYHK-YQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRD 4418
            |.||.: |.|....|:|||..:....:|::..||.|:||:.::|:||..||:     ...|...|
  Fly   961 NCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALK-----LTIQPTPD 1020

Human  4419 DRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGL 4463
            :|.   ||.||||||.||||.|::.|:|::.||.|||: ::||.|
  Fly  1021 ERF---LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQ-TQGFSL 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	XP_016884687.1	DUF908	92..374	CDD:428721
		DUF913	438..904	CDD:461803
		UBA_HUWE1	1407..1446	CDD:270474
		WWE	1707..1768	CDD:460715
		PHA03247	<2825..3156	CDD:223021
		UBM	3100..3133	CDD:464159
		HECTc	4109..4462	CDD:238033	118/360 (33%)
Herc4	NP_001261249.1	ATS1	7..352	CDD:444065	19/66 (29%)
		RCC1	327..390	CDD:395335	18/78 (23%)
		HECTc	715..1060	CDD:238033	118/362 (33%)