Protein Alignment HUWE1 and Smurf

DIOPT Version :10

• Sequence 1: XP_016884687.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4464
• Species: Homo sapiens
• Sequence 2: NP_523779.1
• Gene: Smurf / 36999
• FlyBaseID: FBgn0029006
• Length: 1061
• Species: Drosophila melanogaster
• Alignment Length: 959
• Identity: 277/959 - (28%)
• Similarity: 401/959 - (41%)
• Gaps: 160/959 - (16%)

Human  3555 PENKVSEAQANSGSGASSTTTATSTTSTTTTTAASTTPTPPTAPTPVTSAPALVAATAISTIVVA 3619
            |:.:.:....|||...:......|||.|........     :....||::.....:|.|.:.|..
  Fly   212 PQQRHNTHNGNSGDRQAPAGPTRSTTCTNLMNNGHR-----SRDLSVTASDERRHSTEILSSVGK 271

Human  3620 ASTTVTTPTTATTTVSISPTTKGSKSPAKVSDGG--------------SSSTDFKMVSSGLTENQ 3670
            .:|:.|||.:||||    |..|.|.|.:. |.||              :|||....|.....:|.
  Fly   272 ENTSPTTPVSATTT----PGKKTSSSNSS-SAGGRTLEQRPTNEPATPTSSTTSASVRLHSNDNH 331

Human  3671 LQLSVEVLTSHSCSEEGLEDAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAEL 3735
            ::........|:..|                .:.|..|..:..:||....|.|.....|......
  Fly   332 VKTPKHQTNGHAPPE----------------STPTSPTGQQNYVNGNAQNGSTSGNGSGQAAQPQ 380

Human  3736 REYNLEQQRRAQCETLSPDGLP-----EEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLG---- 3791
            ...|...|..| ..|.||....     .:.|.|..:............||....:...|.|
  Fly   381 SASNGWTQEDA-ATTTSPSTTTSPPRHSQSPPTPNISPPASVTPSANGNVHSPNANSTPAGSGGG 444

Human  3792 ---------GRELQLPSMSMLTSKTSTQKFFLRVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGS 3847
                     |:..|..|......::||:                 ||:::..:..|..|..|.|.
  Fly   445 SRSYTAATPGQRSQRRSSRQQGEESSTR-----------------RRSSRGTRNGGTSGGGGGGG 492

Human  3848 ASS--IQAAVRQLEAEADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDV----DQPS 3906
            :..  ..||:......|...:.: ..|...|..||          ..|.....|..|    |...
  Fly   493 SGQRYASAAIAAANQAARPFLDL-PPGYEMRTTQQ----------GQVYFYHIPTGVSTWHDPRI 546

Human  3907 PSAQDTQSIASDG---TPQGEKEKEERPPELPLLSEQLSLDELWDMLGECLKELEESHDQHAVLV 3968
            |...|||.:..|.   .|.|.::::.....:..:                      .|:......
  Fly   547 PRDFDTQHLTLDAIGPLPSGWEQRKTASGRVYFV----------------------DHNNRTTQF 589

Human  3969 LQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTP----ATPSSLDPFFSREP 4029
            ..|.:....| ....|.:.||..       |.....|.|.|..|.||    |.|....|..:..|
  Fly   590 TDPRLSGSIL-QMIRRGTVPPTS-------AANAGTPAPPSATPATPSAAAAVPPQATPASNATP 646

Human  4030 SSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDVKRKYFRQE 4094
            :::..::: ||           ||.|.:  |.|.....||    :|..|.|  |...|.:..|.|
  Fly   647 TTLTTTTN-PP-----------HRIVPD--LPQGLLEGAD----LLPKYRR--DLVGKLRALRTE 691

Human  4095 LERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMII 4159
            |:.:..  :.....:.|.|:.:||:|||.:.:...::|:.||.:.|:||||.|.||:.|||..::
  Fly   692 LQTMQP--QSGHCRLEVSRNEIFEESYRLIMKMRAKDMRKRLMVKFKGEEGLDYGGVAREWLHLL 754

Human  4160 SREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYK 4224
            ||||.||.|.||:.|..|..|..|||.|..||:|||||.||||.:..||:....|:..||..|||
  Fly   755 SREMLNPQYGLFQYSRDDHYTLQINPDSGVNPDHLSYFHFVGRTLGIAVFHGHCLDGGFTTPFYK 819

Human  4225 HILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVT 4289
            .:|.|.:...|:|..|...::.|.::||:::|.: .:.|||.|...||...|.:|||.||:|.||
  Fly   820 QLLNKPITLGDIEGVDPDLHRSLTWMLESNISGI-IESTFSVENNSFGALVVHELKPGGASIPVT 883

Human  4290 EENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKS 4354
            ||||:|||.|....|....|.:|..|..:||.|:||..|:..|.|:||||:|.|:.:||::|.::
  Fly   884 EENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDWRN 948

Human  4355 NTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGI---QKFQIH 4416
            ||......:.:.|:.|||:.:.|:....||:.||||||:|:||||||.||:|..|.   :.|.||
  Fly   949 NTRLKHCTNETTQVLWFWQVVESYSSEMRARLLQFVTGSSRVPLQGFRALQGSTGAVGPRLFTIH 1013

Human  4417 -RDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQE-CSEGFGL 4463
             ..|..|..||.||||||::|||.||:::.|...|..|::| |  ||.:
  Fly  1014 LTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVEETC--GFAV 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	XP_016884687.1	DUF908	92..374	CDD:428721
		DUF913	438..904	CDD:461803
		UBA_HUWE1	1407..1446	CDD:270474
		WWE	1707..1768	CDD:460715
		PHA03247	<2825..3156	CDD:223021
		UBM	3100..3133	CDD:464159
		HECTc	4109..4462	CDD:238033	159/357 (45%)
Smurf	NP_523779.1	C2_Smurf-like	14..135	CDD:176028
		PRP40	155..>283	CDD:227435	17/75 (23%)
		WW	169..198	CDD:459800
		WW	514..546	CDD:197736	8/42 (19%)
		WW	562..594	CDD:197736	4/53 (8%)
		HECTc	702..1058	CDD:238033	158/358 (44%)