Protein Alignment HUWE1 and Su(dx)

DIOPT Version :10

• Sequence 1: XP_016884687.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4464
• Species: Homo sapiens
• Sequence 2: NP_476753.1
• Gene: Su(dx) / 33379
• FlyBaseID: FBgn0003557
• Length: 949
• Species: Drosophila melanogaster
• Alignment Length: 975
• Identity: 261/975 - (26%)
• Similarity: 408/975 - (41%)
• Gaps: 209/975 - (21%)

Human  3642 GSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEGLED----AANVLLQLSRGD 3702
            ||.||...|..|:.:      |....:...||||.:      .|..|.:    ..|..::|....
  Fly    26 GSASPTPTSSSGAGA------SGSANQGYHQLSVTI------EEASLRNNGFLKPNPYVELLIDS 78

Human  3703 SGTRDTVL-------------------------KLLLNGARHLGYTLCKQIGTLLAELREYNLEQ 3742
            ...|.|.|                         |:|.:.:......|.::|..|...|:.||
  Fly    79 KSKRKTDLVKNSYLPKWNEEFTVLITPNSTLHFKVLDHSSFRKDAMLGERIINLAHILQHYN--- 140

Human  3743 QRRAQCE----TLSPDGLPEEQPQTTKLKGKMQS-----RFDMAE-NVVIVASQKRPLGGRELQL 3797
               .:||    |:......:...:.|| .|::.:     :.||:: .:..||.|:.  |...:|.
  Fly   141 ---GRCEFLELTIDLFVTSKSDNRQTK-SGELVAILNGLKLDMSKLQIQPVAGQQN--GNPPVQA 199

Human  3798 PSMSMLTSKTSTQKFFL-RVLQVIIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLEAE 3861
            .:.|:::...:.:...: ..::..::||..:..:| ..:....|.:.|.....|.||
  Fly   200 VNPSVVSDAAAGRSCMIYGGVRARMRLRSSSGNSN-GGETRSPLPNGGGDHRRSTQA-------- 255

Human  3862 ADAIIQMVREGQRARRQQQAATSESSQSEASVRREESPMDVDQPSPS------------AQDTQS 3914
                 ..|.|.|:.:.|.|...........:...:.:|.....|:|:            .::||.
  Fly   256 -----PPVWEQQQQQSQNQQQPLRMVNGSGAAVPQTAPYPQQPPAPALARPLTQVYGALPENTQP 315

Human  3915 I-----ASDGTPQGEKEKEERPPEL-------------------PLLSEQLSLDEL----WDM-L 3950
            .     |..|...|       ||.:                   |.|..|.:.||.    |:: |
  Fly   316 AAVYLPAGGGAAVG-------PPGVAGPPIEQPGVGLPVSQSTDPQLQTQPADDEPLPAGWEIRL 373

Human  3951 GECLKELEESHDQHAV-----LVLQPAVE--------AFFLVHATERESKPPVRDTR-------E 3995
            .:..:.....|:..:.     ..|.|..|        .:::.|.|.:.:.......|       :
  Fly   374 DQYGRRYYVDHNTRSTYWEKPTPLPPGWEIRKDGRGRVYYVDHNTRKTTWQRPNSERLMHFQHWQ 438

Human  3996 SQLAHI-------------------------KDEPPPLSPAP-----------------LTPATP 4018
            .|.||:                         :|:...|.|.|                 ....|.
  Fly   439 GQRAHVVSQGNQRYLYSQQQQQPTAVTAQVTQDDEDALGPLPDGWEKKIQSDNRVYFVNHKNRTT 503

Human  4019 SSLDPFFSREPSSMHISSSLPPD--------TQKFLRFAETHRTVLNQILRQSTTHLADGPFAVL 4075
            ...||....:..|:.....|||.        .::|.....|.||.... .|......|.|.:.|.
  Fly   504 QWEDPRTQGQEVSLINEGPLPPGWEIRYTAAGERFFVDHNTRRTTFED-PRPGAPKGAKGVYGVP 567

Human  4076 VDYIRVLDFDVKRKYFRQELERLDEGLRKEDMAVHVR----RDHVFEDSYRELHRKSPEEMKNRL 4136
            ..|         .:.||.:|.:.....:...:..|::    |..:|||||.::.|....|::.||
  Fly   568 RAY---------ERSFRWKLSQFRYLCQSNALPSHIKITVTRQTLFEDSYHQIMRLPAYELRRRL 623

Human  4137 YIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVG 4201
            ||:|.||||.|.||:.|||:.::|.|:.||||.||..:..:..:..|||:|:.||:||.||||:|
  Fly   624 YIIFRGEEGLDYGGVSREWFFLLSHEVLNPMYCLFEYANKNNYSLQINPASYVNPDHLQYFKFIG 688

Human  4202 RIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFST 4266
            |.:|.|:|..|.:...||..|||.:|.|.:...|:|:.|..||..|:::.:|::...|.:|.||.
  Fly   689 RFIAMALYHGRFIYSGFTMPFYKRMLNKKLTIKDIETIDPEFYNSLIWVKDNNIDECGLELWFSV 753

Human  4267 EVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISI 4331
            :.:..|.....:||.||....||||||:||:.|:.:.|||..|.:|...|||||.|::|...:..
  Fly   754 DFEVLGQIIHHELKENGEKERVTEENKEEYITLMTEWRMTRGIEQQTKTFLEGFNEVVPLEWLKY 818

Human  4332 FTEQELELLISGLPTIDIDDLKSNTEYHKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKV 4396
            |.|:||||::.|:..:|::|.:.||.|..|..||.|:.|||:.:|..|...||:.|||||||.:|
  Fly   819 FDERELELILCGMQDVDVEDWQRNTIYRHYNRNSKQVVWFWQFVRETDNEKRARLLQFVTGTCRV 883

Human  4397 PLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGF 4461
            |:.|||.|.|.||.|:|.|.:..:.| .||.:|||||:||||.|:|:::|...|..||:| :|||
  Fly   884 PVGGFAELMGSNGPQRFCIEKVGKET-WLPRSHTCFNRLDLPPYKSYDQLVEKLTFAIEE-TEGF 946

Human  4462  4461
              Fly   947  946

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HUWE1	XP_016884687.1	DUF908	92..374	CDD:428721
		DUF913	438..904	CDD:461803
		UBA_HUWE1	1407..1446	CDD:270474
		WWE	1707..1768	CDD:460715
		PHA03247	<2825..3156	CDD:223021
		UBM	3100..3133	CDD:464159
		HECTc	4109..4462	CDD:238033	158/357 (44%)
Su(dx)	NP_476753.1	C2_E3_ubiquitin_ligase	48..173	CDD:175988	25/137 (18%)
		WW	364..396	CDD:197736	3/31 (10%)
		HUL4	<395..946	CDD:227354	188/562 (33%)