Protein Alignment SNUPN and Snup

DIOPT Version :10

• Sequence 1: NP_005692.1
• Gene: SNUPN / 10073
• HGNCID: 14245
• Length: 360
• Species: Homo sapiens
• Sequence 2: NP_001137877.1
• Gene: Snup / 7354429
• FlyBaseID: FBgn0259199
• Length: 351
• Species: Drosophila melanogaster
• Alignment Length: 313
• Identity: 111/313 - (35%)
• Similarity: 165/313 - (52%)
• Gaps: 41/313 - (13%)

Human    39 EQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEE---NKKDDEEMDIDTVKKLPKHYAN 100
            :|.:|::.||:.||.:        |:..:||:..::::|:   .||..:.....  |.:|  |..
  Fly    18 QQKQRQKELLKQQKLR--------RQQEQDDYRPLQNQEKPVPRKKSGKRSGHQ--KGIP--YRP 70

Human   101 QLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNST 165
            |  |||||...|.|| .||::|.||||||.|:|||:|.|.||:|.|:....|.|.|||..:   .
  Fly    71 Q--LSEWLRHKPDDL-NEWLLVPCPVGKRCLVVASKGITKAYSKGGWMFVNFRSSLPGDWQ---L 129

Human   166 AKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFV 230
            .|..|||||:|.|...|:||||.:.:......:|:..|||||:.::. ||....:.::.|..||.
  Fly   130 QKGETILDCVYVEDADTFYVLDAISFGLQEVQECEASFRFYWLRARF-EEHDYDKISENNEKKFK 193

Human   231 GLKNFPCTPESLCDVLSMDFPF------EVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVA 289
            .|.:|.....|..:.....:||      ::||.|||||:..|....||||.||.|:|:.||||
  Fly   194 LLDHFDFEDPSAVEQALHKYPFFPENKPDLDGFLFYHKEASYVCRETPLVCWLFPFMMEDVLG-- 256

Human   290 VPAGPLTTKP-DY-AGHQL-------QQIMEHKKSQKEGMKEKLTHKASENGH 333
            :|.......| || ..|.|       |::.||:::.||  ::|..::..|:.|
  Fly   257 LPVNKCYKAPEDYQPSHVLQYMDAFEQKLAEHRRTLKE--QKKKVNEQKEDPH 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNUPN	NP_005692.1	Necessary for interaction with XPO1. /evidence=ECO:0000269|PubMed:10209022	1..159		47/122 (39%)
		Necessary for interaction with KPNB1 and m3G-cap U1 and U5 snRNP import receptor activity. /evidence=ECO:0000269|PubMed:18187419, ECO:0000269|PubMed:9670026	1..65		7/25 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		1/2 (50%)
		Snurportin1	25..64	CDD:402920	6/24 (25%)
		Snurportin-1_C	97..280	CDD:185717	77/188 (41%)
		Interaction with m3G-cap structure. /evidence=ECO:0000269|PubMed:15920472, ECO:0007744|PDB:1XK5	127..129		1/1 (100%)
		Necessary for binding to the m3G-cap structure. /evidence=ECO:0000269|PubMed:9670026	208..328		42/134 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..360
Snup	NP_001137877.1	Snurportin-1_C	71..249	CDD:185717	76/184 (41%)