DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDH9 and CadN2

DIOPT Version :9

Sequence 1:	NP_057363.3	Gene:	CDH9 / 1007	HGNCID:	1768	Length:	789	Species:	Homo sapiens
Sequence 2:	NP_001036368.2	Gene:	CadN2 / 35071	FlyBaseID:	FBgn0262018	Length:	1799	Species:	Drosophila melanogaster

Alignment Length:	854	Identity:	217/854 - (25%)
Similarity:	350/854 - (40%)	Gaps:	248/854 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    40 LTKDDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDG------AG 98
            :|::|.:.|  .||         :.:.|.||        .|.|: ..|:.|.|||.|      |.
  Fly   145 ITEEDDRNL--PKR---------ILQVTATD--------GDVDR-PINIVYFLTGQGIDPDNPAN 189

Human    99 SLFVIDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFI----------------- 146
            |.|.|:..||||...|.|||             |:..||   |:..|.
  Fly   190 SKFDINRTTGDIFVLKPLDR-------------DQPNGR---PQWRFTVFAQDEGGEGLVGYADI 238

Human   147 -IKIHDINDNEPKFTKDLYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQ------- 203
             :.:.|||||.|:|.:.:|..:|.|....|:||:.::|.|.||.|...:||::|||.:
  Fly   239 QVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKLIYSIEKNVIEEET 303

Human   204 GQPYFSVDPESGIIKTALPDMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRF 268
            |.|.|.::||:|:||||:..:.||....|.:.:.|.|    .|||.||.|.:|.:.|:|:.||:|
  Fly   304 GAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDLNDMPPQF 364

Human   269 PQSTYQFNSPESVPLGTHLGR-----IKANDPDVGENAEMEYSIA--EGDGADMFDVITDKDTQE 326
            .:..:.....|:  .||::..     :...|.|  |....:|.:.  .|.|||.|.::.:.| ..
  Fly   365 TKDEWVTEVDET--NGTYIPETPILTVTVQDED--ETNTFQYKVVPNSGFGADKFAMVRNGD-GT 424

Human   327 GIITVKQNLDFENQML---YTLRVDASNTHPDPRFLHLGPFKDT------AVVKISVEDI-DEPP 381
            |.:.:.|.||:|:.:.   :..|:..::...|      ||....      :.|.:.:.|| |..|
  Fly   425 GSLKIIQPLDYEDPLQSSGFRFRIQVNDKGDD------GPGGSDKYHVAYSWVVVKLRDINDNVP 483

Human   382 VFTKVSYLIEVDEDVKEGSIIGQVTAYDPD-ARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKA 445
            .|.:....:.:.||.|.|:|:.|..|.|.| ..::.:.|.:.|.|:..|.|.| |:.|::...:.
  Fly   484 KFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIVRSTNRKRQFAI-SDRGAVSIQRP 547

Human   446 LDRESSPWHNITVTATEINNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVS 510
            ||||:...|:|.:.|.:..:|.:::...:.:.:.|:||:||.||..|:..:.||.. |:.|..|:
  Fly   548 LDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPTFAQDYKPTLPENVS-GKKILEVA 611

Human   511 VMDKDDPPRGH----KFFFEPVPEFTLNPNFTIV-----DNKDNTAGIMTRKDGYSRNKMSTYLL 566
            ..|.||..||:    .|..:|:....:...|.:.     || :|...|::....:.|....:|.:
  Fly   612 AKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVEYDRRGDN-ENGVAIISSLRPFDREAQKSYAI 675

Human   567 PILIFDNDYPIQSSTGTLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVV 631
            ||.|.||..|..:.|.|||:.:
  Fly   676 PIEIKDNGAPAMTGTSTLTVTI------------------------------------------- 697

Human   632 LFAALKRQRKKEPLIISKDDVRDN--------IVTYNDEGGGEEDTQAFDIGT--LRNPEAREDS 686
                              .||.||        ::.||.:|    .:|...||.  :.:|:..:
  Fly   698 ------------------GDVNDNKMQPGSKSVLVYNYQG----QSQDTPIGRVYVNDPDDWD-- 738

Human   687 KLRRDVMPETIFQIRRTVPLWENIDVQDFIHRRLK-END-------ADPSAPPYDSLATYAYE-- 741
                  :|:..:       .||   ||:  |:|.| :.|       |......| .|....|:
  Fly   739 ------VPDKKY-------YWE---VQE--HQRFKLDTDTGILTMRAGTRRGRY-QLRFKVYDRE 784

Human   742 -GNDSIADSLS-SLESLTADCNQ-----------DYDYLSDWGP-----------RFK-KLAD-M 780
             |.:.|..:|| ::..:||:..|           |.|::..|.|           ||: |||: :
  Fly   785 HGQEDIPANLSVTVRDITAEAVQQAGSMRLSHITDEDFVRTWNPVKNQVEPSKLERFRNKLAELL 849

Human   781 YGGDDSDRD 789
            |    :|||
  Fly   850 Y----TDRD 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDH9	NP_057363.3	Cadherin_repeat	72..155	CDD:206637	28/106 (26%)
		Cadherin_repeat	164..264	CDD:206637	40/106 (38%)
		Cadherin_repeat	272..379	CDD:206637	25/123 (20%)
		Cadherin_repeat	387..484	CDD:206637	27/97 (28%)
		Cadherin_repeat	492..589	CDD:206637	30/105 (29%)
		Cadherin_C	645..782	CDD:279398	40/182 (22%)
CadN2	NP_001036368.2	Cadherin_repeat	41..132	CDD:206637
		Cadherin_repeat	140..248	CDD:206637	36/138 (26%)
		Cadherin_repeat	256..359	CDD:206637	39/106 (37%)
		Cadherin_repeat	379..481	CDD:206637	23/110 (21%)
		Cadherin_repeat	489..586	CDD:206637	27/97 (28%)
		Cadherin_repeat	594..703	CDD:206637	32/171 (19%)
		Cadherin_repeat	724..801	CDD:206637	20/97 (21%)
		EGF_CA	977..1010	CDD:238011
		LamG	1013..1198	CDD:238058
		EGF_2	<1233..1259	CDD:285248
		Laminin_G_2	1293..1428	CDD:280389
		EGF_CA	1497..1535	CDD:238011
		Cadherin_C	1583..1719	CDD:279398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	130	1.000	Domainoid score	I5199
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010