DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SCAMP2 and Scamp

DIOPT Version :9

Sequence 1:	NP_001307707.1	Gene:	SCAMP2 / 10066	HGNCID:	10564	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_001259572.1	Gene:	Scamp / 32470	FlyBaseID:	FBgn0040285	Length:	343	Species:	Drosophila melanogaster

Alignment Length:	375	Identity:	137/375 - (36%)
Similarity:	203/375 - (54%)	Gaps:	53/375 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     2 SAFDTNPFADPVDVNPFQDPSVTQLTNAPQG----GLAEFNPFSETNAATTVPVTQLPGSSQPAV 62
            |..|.|||.:|...|||.||::.|......|    .|.::|||.|    ...|..|:..::..||
  Fly     4 SGLDENPFGEPNLDNPFADPAIQQARRLQSGAALVSLEDYNPFEE----QAKPQLQINSTNTAAV 64

Human    63 LQPSVEPTQPTPQLLLRQASKFPPAQFLAVSELSERQMLLGGESILRDSYMRKLPKAVVSAAQAG 127
            :||              .:...||.|..:          ||..:          |...:......
  Fly    65 VQP--------------LSQNIPPPQTSS----------LGASA----------PSTSIQITSEE 95

Human   128 LLRQQEELDRKAAELERKERELQNTVANLHVRQNNWPPLPSWCPVKPCFYQDFSTEIPADYQRIC 192
            |.|:|||||||||||:|:|::||..|..|    |||||||....|||||||||..|||.::|::.
  Fly    96 LQRRQEELDRKAAELDRREQQLQGNVPQL----NNWPPLPDNFCVKPCFYQDFEVEIPPEFQKLV 156

Human   193 KMLYYLWMLHSVTLFLNLLA--CLAWFSGNSSKGVDFGLSILWFLIFTPCAFLCWYRPIYKAFRS 255
            |.|||:|:.:::||..|::.  .|.:.:|...   .|.|:|.:.::|:|.:::||:||.|||||:
  Fly   157 KRLYYIWIFYTMTLLANVIGGLILLFHAGEFE---TFFLAIFYTMLFSPASYVCWFRPAYKAFRN 218

Human   256 DNSFSFFVFFFVFFCQIGIYIIQLVGIPGLGDSGWIAALSTLDNHS--LAISVIMMVVAGFFTLC 318
            |:||:|.||||::|.|....|:|.||...:|..|:|.|:...|..:  :.:.::::.||..||..
  Fly   219 DSSFNFMVFFFIYFFQTLYSIVQAVGFNKMGYCGFITAIGQFDGQASGIIVGILLLNVAFCFTAV 283

Human   319 AVLSVFLLQRVHSLYRRTGASFQQAQEEFSQGIFSSRTFHRAASSAAQGA 368
            ||.:|.::.::||:||.||||..:||.||:.....::....|||||...|
  Fly   284 AVANVLMITKIHSIYRSTGASMAKAQAEFTTEFLRNQHVQEAASSAVNTA 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SCAMP2	NP_001307707.1	SCAMP	160..336	CDD:367838	74/179 (41%)
Scamp	NP_001259572.1	SCAMP	125..301	CDD:282056	74/178 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141106
Domainoid	1	1.000	185	1.000	Domainoid score	I3381
eggNOG	1	0.900	-	-		E1_KOG3088
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I2913
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51893
OrthoDB	1	1.010	-	-		D544579at33208
OrthoFinder	1	1.000	-	-		FOG0000703
OrthoInspector	1	1.000	-	-		otm40287
orthoMCL	1	0.900	-	-		OOG6_101583
Panther	1	1.100	-	-	O	PTHR10687
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X309
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770