DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NR1H3 and Hr96

DIOPT Version :9

Sequence 1:	XP_024304052.1	Gene:	NR1H3 / 10062	HGNCID:	7966	Length:	511	Species:	Homo sapiens
Sequence 2:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	112/548 - (20%)
Similarity:	190/548 - (34%)	Gaps:	181/548 - (33%)

- Green bases have known domain annotations that are detailed below.

Human    98 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAG 162
            |:||||||.|:::|.::||.||.||||:.:....:.|....:|.:....||.||:||||||...|
  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLDIG 71

Human   163 MREECVLSEEQIRLKKLKRQE--------------------EEQAH------------------- 188
            |:.|.::|||...:|:.|.:.                    ||:.|
  Fly    72 MKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSGSQD 136

Human   189 ---------------------------------------ATSLPPRASSPPQILPQLSPEQLGMI 214
                                                   ..|.|.|||.....|.:...|.:.::
  Fly   137 SQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAISVM 201

Human   215 EKLVAAQQQCNRRSF------SDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAK 273
            ||::::|:...|...      .|.|::.. .....|.:......:|.......:..:.:|||...
  Fly   202 EKVISSQKDALRLVSHLIDYPGDALKIIS-KFMNSPFNALTVFTKFMSSPTDGVEIISKIVDSPA 265

Human   274 QLPGFLQ---LSREDQIALLK------TSAIEV------AGEGQGMKGEAEWDYLWEGPPDIELG 323
            .:..|:|   .|.||.|.::.      ..|:.:      .|.....:..|:...|.:..|.::..
  Fly   266 DVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAVKPA 330

Human   324 EP---------NLLGSRDEENRPP-----------------WKRPCSKTSPPSPRLRFAACVQV- 361
            .|         ::||     |.||                 .::|.:.:|.|.|.:..:....:
  Fly   331 APAERADTVIQSMLG-----NSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLK 390

Human   362 MLLETSRRYNPGSESITFLKDFSYNR-EDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIA 425
            ..::|:....|..:|     |||.|. |......:::|:        :|.|.:|.
  Fly   391 TFMQTNYNDEPSLDS-----DFSINSIESVLSEVIRIEY--------QAFNSIQQ---------- 432

Human   426 ISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPH-------------DRLMFPRMLMKLVS 477
                :|.|  |::::.. ..|.|| ...::..:...||             ||.:.....|||..
  Fly   433 ----AASR--VKEEMSY-GTQSTY-GGCNSAANNSQPHLQQPICAPSTQQLDRELNEAEQMKLRE 489

Human   478 LRTLSSV----HSEQVFALRLQDKKLPP 501
            ||..|..    ..|.:.||.:.|.::.|
  Fly   490 LRLASEALYDPVDEDLSALMMGDDRIKP 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NR1H3	XP_024304052.1	NR_DBD_LXR	78..178	CDD:143534	35/79 (44%)
NR1H3	XP_024304052.1	NR_LBD_LXR	210..509	CDD:132752	65/358 (18%)
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/90 (41%)
		NR_LBD	462..>573	CDD:299703	14/56 (25%)
		NR_LBD_F1	523..702	CDD:132727
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157558
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4152
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.990