Protein Alignment NR1H3 and EcR

DIOPT Version :10

• Sequence 1: NP_001238863.1
• Gene: NR1H3 / 10062
• HGNCID: 7966
• Length: 453
• Species: Homo sapiens
• Sequence 2: NP_724460.1
• Gene: EcR / 35540
• FlyBaseID: FBgn0000546
• Length: 878
• Species: Drosophila melanogaster
• Alignment Length: 572
• Identity: 190/572 - (33%)
• Similarity: 268/572 - (46%)
• Gaps: 132/572 - (23%)

Human     3 QTSWNPLGGTCKQPPGRTHSAVELWKPGAQDASSQAQG--------------------------- 40
            ||:..|:.|......|.|:..   :.|||.:..:.|.|
  Fly    92 QTTIIPINGNANGNGGSTNGQ---YVPGATNLGALANGMLNGGFNGMQQQIQNGHGLINSTTPST 153

Human    41 -------------------GSSCILREEARMPH------SAGGTAGVGLEAAEPTALLTRAEPPS 80
                               |...||......|:      ..||..|:|:.......|..:..|.|
  Fly   154 PTTPLHLQQNLGGAGGGGIGGMGILHHANGTPNGLIGVVGGGGGVGLGVGGGGVGGLGMQHTPRS 218

Human    81 EPT--------EIRP---------------QKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCE 122
            :..        ::.|               :|.||||||: :..|||.||||:|||:|||.|:||
  Fly   219 DSVNSISSGRDDLSPSSSLNGYSANESCDAKKSKKGPAPR-VQEELCLVCGDRASGYHYNALTCE 282

Human   123 GCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKK--L 185
            ||||||||||.|.|.|.|..|..|.||.|||||||||||:||...|||.|||:.|.|..:|:  .
  Fly   283 GCKGFFRRSVTKSAVYCCKFGRACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREK 347

Human   186 KRQEEEQAHATS------------------------------LPPRASS----PPQIL------- 209
            |.|:|:....||                              .||:.::    |.:||
  Fly   348 KAQKEKDKMTTSPSSQHGGNGSLASGGGQDFVKKEILDLMTCEPPQHATIPLLPDEILAKCQARN 412

Human   210 -PQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQE 273
             |.|:..||.:|.||:..|....:.|..|..|:    |:....:.......|.|.||:.|::||.
  Fly   413 IPSLTYNQLAVIYKLIWYQDGYEQPSEEDLRRI----MSQPDENESQTDVSFRHITEITILTVQL 473

Human   274 IVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQ 338
            ||:|||.||.|.::.:||||.|||..:.|||:|..:|||:..|:||.|..:.||.|:.:..||:
  Fly   474 IVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHSSDSIFFANNRSYTRDSYKMAGM- 537

Human   339 VEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHH 403
            .:.|..:..|.|.|..:::::.|:|||.||.||| |||.::....||.:|..|::.|..|:...|
  Fly   538 ADNIEDLLHFCRQMFSMKVDNVEYALLTAIVIFS-DRPGLEKAQLVEAIQSYYIDTLRIYILNRH 601

Human   404 PHDRL---MFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVH 452
            ..|.:   .:.::|..|..||||.:.::|..|:|:|:::|||..|.||||||
  Fly   602 CGDSMSLVFYAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVH 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NR1H3	NP_001238863.1	NR_DBD_LXR	84..184	CDD:143534	63/114 (55%)
		NR_LBD_LXR	216..451	CDD:132752	89/237 (38%)
EcR	NP_724460.1	NR_DBD_EcR	261..351	CDD:143535	57/89 (64%)
		NR_LBD_EcR	420..652	CDD:132736	89/237 (38%)