Protein Alignment ABCC9 and MRP

DIOPT Version :9

• Sequence 1: NP_001364202.1
• Gene: ABCC9 / 10060
• HGNCID: 60
• Length: 1549
• Species: Homo sapiens
• Sequence 2: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Alignment Length: 1685
• Identity: 532/1685 - (31%)
• Similarity: 837/1685 - (49%)
• Gaps: 295/1685 - (17%)

Human     5 FCG----NNISSYNINDGVLQNSCFVD-ALNLVPHVFL-LFITFPILFIGWGSQSSKVQIHHNTW 63
            |||    |...::..||... ..||.. ||...|..|. .|:.|...::       |..:..|
  Fly    12 FCGSTFWNATETWYTNDPDF-TPCFEQTALVWTPCAFYWAFVIFDFYYL-------KASLDRN-- 66

Human    64 LHFPGHNL---RWILTFALLFVHVCEIAEGIV---SDSRRESRHLHLFMPAVMGFVATTTSIVYY 122
              .|.:.|   :.::...||.:...::...:|   .||......|.::.| ::.|.......::.
  Fly    67 --IPWNKLNVSKALVNLGLLVITALDLIMALVKKGGDSELPLYDLDVWGP-IIKFATFLLLFIFI 128

Human   123 -----HNIETSNFPKLLLALFLYWVMAFITKTIKLVKYCQSGLDISNLR---------------- 166
                 :.::|:.      ..|::|.:.    |:..:..|::.:.:...|
  Fly   129 PLNRKYGVQTTG------CQFIFWFLL----TVLSIPRCRTEVRLDAERQKILNSQQPSEQDFSW 183

Human   167 -----------FCITGMMVILN----GLLMAVEINVIRVRRYVFFMNPQKVK---PPEDLQDLGV 213
                       |..|.:|:|||    |:                   |::.|   ...::.:|..
  Fly   184 EEYQFVSFFIFFTFTSIMLILNCFADGM-------------------PRQTKYQRGENEIPELSA 229

Human   214 RFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKL----------PI-----AMRAVTNY-- 261
            .|       ||:.||.|.:.:.:..::.|::.|.:..|          ||     ......||
  Fly   230 SF-------LSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKN 287

Human   262 --------------VCLKDAYEE---QKKKVADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADL 309
                          |..::.:.|   :||.:|       ||...:|::||...|..:..:...|.
  Fly   288 KARVEPKAQFSNGNVTFENPHGEKNGRKKGMA-------SIMPPIYKSFGGVFLFGALMKLFTDT 345

Human   310 LGFAGPLCISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYY 374
            |.||.|..:|.|:..| |.|:......||              :.|||||: |...:||:...|:
  Fly   346 LTFAQPQVLSLIISFV-EAQDAEPEWKGI--------------LYAVLLFV-LAAAQTFILGQYF 394

Human   375 VTI-ETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMP 438
            ..: ..|:.:|.||:..||.|.||:  ||.:..|.|:|:|.||:|::..:.|........:|:.|
  Fly   395 HRMFIVGLRIRTALINAIYRKALRI--SNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAP 457

Human   439 VQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIK 503
            :||.:.:..|:..||.|.|.|.||:::|.|:...||:::...|...:.|..||:|..||:|.|||
  Fly   458 LQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIK 522

Human   504 LLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYAS-GNNLK 567
            :|||||||..|.|.|.:.|.||:::|::.|...:.:.|:.:..|....|.||.|:...| .|.|.
  Fly   523 VLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLTSEANQLS 587

Human   568 PAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCK 632
            ..:...|::||.::..||.:|..:.....:..:||.::|:||.|:|:       ..:|:..:|.|
  Fly   588 VEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEEL-------DPNSVLHDSSK 645

Human   633 KHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIRIPT 697
            .|                                    .:.:.||.||||..: ||.||:|.:..
  Fly   646 PH------------------------------------PMSIENGEFSWGDEI-TLRNINIEVKK 673

Human   698 GQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLL 762
            |.|..:||.||.||||::.|.||||:.|.|.|:...                 .:||..|:.|:.
  Fly   674 GSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVG-----------------KLAYVPQQAWIQ 721

Human   763 NATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827
            ||||.:||.||..::::||..|.|||:|:.|||:|..||.|||||:||||||||:|||.:|||:|
  Fly   722 NATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVY 786

Human   828 QNTNIVFLDDPFSALDIHLSDHLMQE-----GILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887
            .:.::..||||.||:|.|:..|:.:|     |||.     :::.|||||.:.:|...|.|..:|.
  Fly   787 SDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILA-----RKSRVLVTHGVTFLPQVDSIYVIKM 846

Human   888 GSVLREGT------------------LKDIQTKDVELYEHWKTLMNRQD-QEL----EKDMEADQ 929
            |.:...||                  |::...::.||.:..:.:.:..| .||    ||.::..:
  Fly   847 GEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLAR 911

Human   930 T--------------------TLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLR 974
            |                    :|.|:|.|:..:...|.|....:.:|.|.:..|.:...|
  Fly   912 TESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEVEGKLIETEKSQT----- 971

Human   975 TKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSI-NNTGKADQ---TYY 1035
            ..:.:.....|:.|.|.||.:..:....:..:..:..:.||..|.::.:: |:||..|.   .|.
  Fly   972 GGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVANDTGLRDMYLGVYG 1036

Human  1036 VAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPI-RFFDTTPLGLILNRFSAD 1099
            ..||    |.|: |.....:.|...|..|||.:|:.||..||.|.: ||||.||:|.:||.||.|
  Fly  1037 AFGF----GQGV-LAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGD 1096

Human  1100 TNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYFIQKYFRVASKDLQELD 1164
            .:::|:.:|.|::|......:.|:.|.:||.:||:||..::|:...:||.|:::...|:.|..|:
  Fly  1097 MDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLE 1161

Human  1165 DSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIAYLFLSAANRWLEVRTDYLGAC 1229
            ..::.|:..|||||..|.:||||:....||.:......|.|.:.......|||||.:|.:.:|..
  Fly  1162 SVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNL 1226

Human  1230 IVLTASI-ASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSF-LTMESEN 1292
            |:|.||: |.:.|.:|.|||||.:.|||.:|..|||:||..:|:|..:.:|:::..: .|.:...
  Fly  1227 IILFASLFAVLGGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAP 1291

Human  1293 YEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSL 1357
            :|...|.:: |::|||||.::..:..|||...|..||:.|...|:.|:||||.||||:|||||:|
  Fly  1292 WELEQDKNK-PKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTL 1355

Human  1358 AFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDP-ECKCTDDRLWEA 1421
            |.||:::...|:|.|||:||:.:.||.|||||:||.|||:|||||:|.|||| |.| |||.:|:|
  Fly  1356 ALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIK-TDDEIWKA 1419

Human  1422 LEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENI 1486
            ||::.||:.||||..||:..:.|||||.|||||||.|||||.:||:.:|::|||||::|:.|:::
  Fly  1420 LELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDL 1484

Human  1487 LQKVVMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVR 1546
            :||.:.|.|.:.||:|||||::|||.:|.|||:.:|.|:|:.:|..||......|.|..:
  Fly  1485 IQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAK 1544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC9	NP_001364202.1	MRP_assoc_pro	222..1546	CDD:188098	489/1415 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	944..967		5/22 (23%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	530/1683 (31%)
		ABC_membrane	338..601	CDD:279056	94/280 (34%)
		ABCC_MRP_domain1	649..848	CDD:213217	96/221 (43%)
		ABC_membrane	988..1260	CDD:279056	95/276 (34%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	121/220 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151537
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650