Protein Alignment CDH8 and shg

DIOPT Version :10

• Sequence 1: NP_001787.2
• Gene: CDH8 / 1006
• HGNCID: 1767
• Length: 799
• Species: Homo sapiens
• Sequence 2: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Alignment Length: 1260
• Identity: 255/1260 - (20%)
• Similarity: 369/1260 - (29%)
• Gaps: 608/1260 - (48%)

Human    71 LEEFSGP------------EPILVGRLHTD-LDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIK 122
            |:.|:.|            :|.::..|:|. .:..:.|..::.:..|       |:||  |...|
  Fly   315 LKNFTHPIATLRAVSNMPDKPEVIFELNTGRTEQTNSKNTFVFNQIG-------NEVT--ISLGK 370

Human   123 RLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSIL----- 182
            .||.|...:||||...   ..:..|....:..|:|:|:|||.      ||:..|...:||
  Fly   371 TLDYEAITDYTLTMIV---RNTHELGTEHQIKIQVEDVNDNI------PYYTEVKSGTILENEPP 426

Human   183 GTSVTNVTATDADDPVYGNSAKLV--YSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQ 245
            ||.|..|.|.|.|    |.||..:  :.:.:.:.||:|:|.|..| |||...|||.::.|.|.:.
  Fly   427 GTPVMQVRAFDMD----GTSANNIVSFELADNREYFTIDPNTGNI-TALTTFDREERDFYNVKVI 486

Human   246 AKDMG------------GHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFS-VPEDVVLGTAIGR 297
            |.|..            ||.       ...:::.|.||:.|.|.|..|... :.||....|.:..
  Fly   487 ASDNSPSSLFDNGEPNRGHQ-------VFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIE 544

Human   298 VKANDQDIGENA-QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVH 361
            |||.|:|   || |..|.|..|:....|:|    ..:.|.|.:.:.||:||...|.|||.|.:
  Fly   545 VKAEDED---NASQILYSIESGNVGDAFKI----GLKTGKITVNQKLDYETITEYELKVRAFD-- 600

Human   362 IDPRFSGRGPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPI 425
                    |.:.|..||.|.:||. |.||||.. .|.:.:.|....:..|..|.|.||||.
  Fly   601 --------GIYDDYTTVVIKIEDVNDNPPVFKQ-DYSVTILEETTYDDCILTVEAYDPDIK---- 652

Human   426 RFSIDRHTDLERQFNINADDGK---------ITLATPLDRELSVWHNITIIATEIRNH------- 474
                ||:.|....::|:.:||.         :.|...|||:....|....:..:..:.
  Fly   653 ----DRNADQHIVYSIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTV 713

Human   475 SQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEM 539
            |.:..|.|.:|  |:|||||...:|...:..||..||.|:| :.|.|.||......|.:.:..|.
  Fly   714 STVKEVTVTLK--DINDNAPFLINEMPVYWQENRNPGHVVQ-LQANDYDDTPGAGNFTFGIDSEA 775

Human   540 VNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTS-------------- 590
              .|:...|.:.|.  ..|..:..|:|:.|:.|.:||.|||||.|..|:.|
  Fly   776 --TPDIKTKFSMDG--DYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAM 836

Human   591 ----------------------------------------------------------------- 590
                                                                             
  Fly   837 SEGSSRIFIYNYKGEAPETDIGRVFVDDLDDWDLEDKYFEWKDLPHDQFRLNPSTGMITMLVHTA 901

Human   591 ----------------------------------------------------------------- 590
                                                                             
  Fly   902 EGEYDLSFVVTEDSMFVPRHSVDAYVTVVVRELPEEAVDKSGSIRFINVTKEEFISVPRDFQSPD 966

Human   591 ----------------------------------TLTIR-------------------------- 595
                                              ||.:|
  Fly   967 ALSLKDRLQLSLAKLFNTSVSNVDVFTVLQNENHTLDVRFSAHGSPYYAPEKLNGIVAQNQQRLE 1031

Human   596 ----------------------------------------------------------------- 595
                                                                             
  Fly  1032 NELDLQMLMVNIDECLIEKFKCEESCTNELHKSSVPYMIYSNTTSFVGVNAFVQAQCVCEAPLMR 1096

Human   596 --------------VCGCSN--------------------------------------------- 601
                          ||.|.:
  Fly  1097 RCLNGGSPRYGENDVCDCIDGFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGL 1161

Human   602 --------------------------------------------------------DGVVQSCNV 610
                                                                    |.::|..::
  Fly  1162 IMYLGPLNFNPLLAISDFLALELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIILQRTSI 1226

Human   611 EAYV------------LPIG----------LSMGA------------------------------ 623
            |..|            .|||          |.:|.
  Fly  1227 EMTVDNCRLSTCQTLGAPIGPNEFLNVNAPLQLGGTPVDLEQLGRQLNWTHVPNQKGFFGCIRNL 1291

Human   624 --------------------------------------LIAILACIILLLVIVVLFVTLRRHKN- 649
                                                  :|||:.|:.|||:|::..|..::.||
  Fly  1292 TINEQTYNLGMPSVFRNIDSGCQQSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKKQKNG 1356

Human   650 --EPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPR--Q 710
              |    ||.:|:||.||.|:||||||.||: :|:..|:.    ..|...|..|.     |.  |
  Fly  1357 WHE----KDIDDIRETIINYEDEGGGERDTD-YDLNVLRT----QPFYEEKLYKD-----PHALQ 1407

Human   711 GLAPVPNGV-DVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFD 774
            |....||.: |:.:|:..:....|.|..|...|.::.|.|||.|:..||||||.|.|.|.|.|||
  Fly  1408 GNMRDPNDIPDIADFLGDKKENCDRDVGATTVDDVRHYAYEGDGNSDGSLSSLASCTDDGDLNFD 1472

Human   775 YLSDWGPRFKRLGELYSVGESDKET 799
            |||::||||::|.::|....||.::
  Fly  1473 YLSNFGPRFRKLADMYGEEPSDTDS 1497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDH8	NP_001787.2	CA	87..165	CDD:214520	22/78 (28%)
		Cadherin_repeat	171..272	CDD:206637	35/119 (29%)
		Cadherin_repeat	281..387	CDD:206637	35/108 (32%)
		Cadherin_repeat	395..492	CDD:206637	26/112 (23%)
		Cadherin_repeat	499..602	CDD:206637	37/486 (8%)
		CADH_Y-type_LIR	732..790	CDD:460041	30/57 (53%)
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637
		Cadherin_repeat	200..292	CDD:206637
		CA	332..410	CDD:214520	24/95 (25%)
		Cadherin_repeat	417..518	CDD:206637	32/112 (29%)
		Cadherin_repeat	531..619	CDD:206637	34/104 (33%)
		Cadherin_repeat	627..729	CDD:206637	26/111 (23%)
		Cadherin_repeat	736..834	CDD:206637	31/102 (30%)
		LamG	1127..1294	CDD:238058	9/166 (5%)
		CADH_Y-type_LIR	1430..1489	CDD:460041	30/58 (52%)