DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDH8 and CadN

DIOPT Version :10

Sequence 1:NP_001787.2 Gene:CDH8 / 1006 HGNCID:1767 Length:799 Species:Homo sapiens
Sequence 2:NP_001027277.1 Gene:CadN / 35070 FlyBaseID:FBgn0015609 Length:3101 Species:Drosophila melanogaster


Alignment Length:576 Identity:175/576 - (30%)
Similarity:294/576 - (51%) Gaps:72/576 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    94 KKIKYILSGDG------AGTIFQINDVTGDIHAIKRLDREE---KAEYTLTAQAVDWETSKPLEP 149
            :.|.|.|:|.|      |.:.|.||..||:|..:|.|||::   :.::..|..|.| |..:.|..
  Fly  1553 QNIVYFLTGQGIDPDNPANSKFDINRTTGEIFVLKPLDRDQPNGRPQWRFTVFAQD-EGGEGLVG 1616

Human   150 PSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE--- 211
            .::..:.::|||||||.|..|.|...|.|....|..|..:||.|.|||..|::|:|||||.:   
  Fly  1617 YADVQVNLKDINDNAPIFPQGVYFGNVTENGTAGMVVMTMTAVDYDDPNEGSNARLVYSIEKNVI 1681

Human   212 ----GQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDN 272
                |.|.|.|||:|.:||||:..:|||...:|.:.:.|.|    .|||.||.|.::.:.|:||.
  Fly  1682 EEETGSPIFEIEPDTGVIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTASIRVKDINDM 1742

Human   273 PPKFAQSLYHFSVPEDVVLGTAIGR-----VKANDQDIGENAQSSYDIIDGDGTALFEITSDAQA 332
            ||:|.:..:...|  |...|||:..     |..:|:|  |..:..|.:||..|....:.|. .:.
  Fly  1743 PPQFTKDEWFTEV--DETDGTALPEMPILTVTVHDED--ETNKFQYKVIDNSGYGADKFTM-VRN 1802

Human   333 QDGI--IRLRKPLDFETK---KSYTLKVEAANVHIDPRFSGRGPFKDT-------ATVKIVVEDA 385
            .||.  :::.:|||:|.:   ..:..:::.         :.:|...|.       :.|.:.:.|.
  Fly  1803 NDGTGSLKIVQPLDYEDQLQSNGFRFRIQV---------NDKGEDNDNDKYHVAYSWVVVKLRDI 1858

Human   386 -DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKI 448
             |..|.|......:.|.|:..:.:.:.:..|.|||. ..|.:.:||||.:|.:|||.|| .:|.:
  Fly  1859 NDNKPHFERANVEVSVFEDTKVGTELEKFKATDPDQGGKSKVSYSIDRSSDRQRQFAIN-QNGSV 1922

Human   449 TLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQV 513
            |:...||||:...|.:.|:|.:..:..:.:...:.:.|.|:|||||:|..:|...|.|:..|.:|
  Fly  1923 TIQRSLDREVVPRHQVKILAIDDGSPPKTATATLTVIVQDINDNAPKFLKDYRPVLPEHVPPRKV 1987

Human   514 IQTVSAMDKDDPK-NGHYFLYSLLP--EMVNNPNFTIKKNE----DNSLSILAKHNGFNRQKQEV 571
            ::.::..|.|..| ||..|.:.|.|  :.:...:|.:::::    .:.:::::....|:|::|:.
  Fly  1988 VEILATDDDDRSKSNGPPFQFRLDPSADDIIRASFKVEQDQKGANGDGMAVISSLRSFDREQQKE 2052

Human   572 YLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYV---------LPIG 618
            |::||:|.|.|:|.::.|||||: :.|..||..:|..:.:.:|         .|||
  Fly  2053 YMIPIVIKDHGSPAMTGTSTLTV-IIGDVNDNKMQPGSKDIFVYNYQGQSPDTPIG 2107

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDH8NP_001787.2 CA 87..165 CDD:214520 26/79 (33%)
Cadherin_repeat 171..272 CDD:206637 43/107 (40%)
Cadherin_repeat 281..387 CDD:206637 24/123 (20%)
Cadherin_repeat 395..492 CDD:206637 29/97 (30%)
Cadherin_repeat 499..602 CDD:206637 30/109 (28%)
CADH_Y-type_LIR 732..790 CDD:460041
CadNNP_001027277.1 Cadherin_repeat 178..301 CDD:206637
CA_like 449..541 CDD:481204
Cadherin_repeat 549..>625 CDD:206637
Cadherin_repeat 655..752 CDD:206637
Cadherin_repeat 765..853 CDD:206637
Cadherin_repeat 862..964 CDD:206637
Cadherin_repeat 973..1074 CDD:206637
Cadherin_repeat 1083..1166 CDD:206637
Cadherin_repeat <1219..1298 CDD:206637
Cadherin_repeat 1310..1414 CDD:206637
Cadherin_repeat 1423..1514 CDD:206637
Cadherin_repeat 1522..1630 CDD:206637 24/77 (31%)
Cadherin_repeat 1638..1741 CDD:206637 42/106 (40%)
CA 1770..1863 CDD:214520 20/104 (19%)
Cadherin_repeat 1871..1966 CDD:206637 29/95 (31%)
Cadherin_repeat 1974..2083 CDD:206637 31/109 (28%)
EGF 2350..2380 CDD:394967
LamG 2385..2570 CDD:238058
EGF_2 2605..2631 CDD:400365
LamG 2637..2797 CDD:238058
EGF_CA 2869..2907 CDD:238011
CADH_Y-type_LIR 3029..3088 CDD:460041
Blue background indicates that the domain is not in the aligned region.

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