Protein Alignment DNM1L and Dnm1l

DIOPT Version :10

• Sequence 1: NP_001265393.1
• Gene: DNM1L / 10059
• HGNCID: 2973
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_001346936.1
• Gene: Dnm1l / 74006
• MGIID: 1921256
• Length: 755
• Species: Mus musculus
• Alignment Length: 755
• Identity: 738/755 - (97%)
• Similarity: 743/755 - (98%)
• Gaps: 6/755 - (0%)

Human     1 MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLIL 65
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||
Mouse     1 MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLIL 65

Human    66 QLVHVSQEDKRKTTGEEN------DPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEI 124
            ||||||.|||||||||||      :||||||||||||||||||||||||||||||||||||||||
Mouse    66 QLVHVSPEDKRKTTGEENGKFQSWNPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEI 130

Human   125 ENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISN 189
            ||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   131 ENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISN 195

Human   190 PNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGI 254
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 PNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGI 260

Human   255 IGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKT 319
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 IGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKT 325

Human   320 RINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFH 384
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 RINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFH 390

Human   385 ETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVH 449
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 ETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVH 455

Human   450 EEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDF 514
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 EEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDF 520

Human   515 ADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRE 579
            ||||||||||||||||||||||||||.|||||||||||||||||||.||||||||||||||:|||
Mouse   521 ADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGKLIQDNRRE 585

Human   580 TKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVP 644
            ||||.|.|||:|||.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 TKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVP 650

Human   645 VARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLL 709
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 VARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLL 715

Human   710 DDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW 749
            ||||||||||||||||||||||||||||||||||||||||
Mouse   716 DDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNM1L	NP_001265393.1	DLP_1	23..315	CDD:206738	287/297 (97%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	32..39		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	58..60		1/1 (100%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	159..162		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	228..231		2/2 (100%)
		Dynamin_M	238..523	CDD:460033	284/284 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	258..261		2/2 (100%)
		Middle domain. /evidence=ECO:0000269|PubMed:15208300	357..502		144/144 (100%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:9731200	461..698		229/236 (97%)
		B domain. /evidence=ECO:0000269|PubMed:15208300	515..582		63/66 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..603		59/66 (89%)
		GED	653..743	CDD:460495	89/89 (100%)
		Important for homodimerization. /evidence=ECO:0000269|PubMed:23584531	667..681		13/13 (100%)
Dnm1l	NP_001346936.1	DLP_1	23..321	CDD:206738	287/297 (97%)
		Dynamin_M	244..529	CDD:460033	284/284 (100%)
		GED	659..749	CDD:460495	89/89 (100%)