DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNM1L and shi

DIOPT Version :9

Sequence 1:	NP_001265393.1	Gene:	DNM1L / 10059	HGNCID:	2973	Length:	749	Species:	Homo sapiens
Sequence 2:	NP_001259588.1	Gene:	shi / 45928	FlyBaseID:	FBgn0003392	Length:	896	Species:	Drosophila melanogaster

Alignment Length:	807	Identity:	303/807 - (37%)
Similarity:	447/807 - (55%)	Gaps:	116/807 - (14%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEALIPVINKLQDVFNTVGADI-IQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLI 64
            |::||.::|||||.|.::|..: :.||||.|||.||:|||||||:.||:|.||||:|||||||||
  Fly     1 MDSLITIVNKLQDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLI 65

Human    65 LQLVHVSQEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETE 129
            |||::                           ||  .|:|:|||.|.|.::.|||||:|||:||:
  Fly    66 LQLIN---------------------------GV--TEYGEFLHIKGKKFSSFDEIRKEIEDETD 101

Human   130 RISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSII 194
            |::|:|||:|..||:|:::||:|:||||:||||:|||.:||||.|||.||:::|.:||.....:|
  Fly   102 RVTGSNKGISNIPINLRVYSPHVLNLTLIDLPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLI 166

Human   195 LAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVN 259
            ||||.||||:|.|:|||:::||||.|.||:.|||||||||.||||.|:|..:::|::.|.|||||
  Fly   167 LAVTPANTDLANSDALKLAKEVDPQGVRTIGVITKLDLMDEGTDARDILENKLLPLRRGYIGVVN 231

Human   260 RSQLDINNKKSVTDSIRDEYAFL--QKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRI- 321
            |||.||..:|.:..::..|..|.  ...|..:|:|.||.||.|.||:.|.:||||.||.|:.::
  Fly   232 RSQKDIEGRKDIHQALAAERKFFLSHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQ 296

Human   322 -NVLAAQYQSLLNSYGEPVDD--KSATLLQLITKFATEYCNTIEGT-AKYIETSELCGGARICYI 382
             .:|..:.:.....:.:|.|.  |:..:||:|.:..:::..||||: :..:.|:||.|||:|..|
  Fly   297 KQMLTLEKEVEEFKHFQPGDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRI 361

Human   383 FHETFGRTLESVDPLGGLNTI--DILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCV 445
            |||..  ..|.|........:  :|..||||..|.|..||.|:::||.:|||||..|:||.::||
  Fly   362 FHERL--RFEIVKMACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCV 424

Human   446 ELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTK 510
            :||.:|:..:::.|    |.::.|:|:|.:....::|..:|:|.....|.:..|:..||||:||.
  Fly   425 DLVVQELSVVVRMC----TAKMSRYPRLREETERIITTHVRQREHSCKEQILLLIDFELAYMNTN 485

Human   511 HPDFADACGLMNNNIEEQRRNRL-ARELPSAVSRD-----------KSSKVPSA-------LAPA 556
            |.||   .|..|...:.:..|:. .|:|.:.|.|.           |..|:..:       .:|:
  Fly   486 HEDF---IGFANAQNKSENANKTGTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPS 547

Human   557 SQEPSP---AASAEA------------------DGKLIQD--------SRRETKNVASGGGGVGD 592
            :....|   ..::|:                  ||..::|        |||.|..:.|..|
  Fly   548 TGGSRPYWFVLTSESISWYKDEDEKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDG---- 608

Human   593 GVQEPTTGNWRGMLKTSKAEELLAEE----KSKPIPIMPAS--PQKGHAVNLLDVPVPVARKLSA 651
                      |.:.|..|..||..|.    :|.....:.|.  |:|.......|...........
  Fly   609 ----------RNVYKDYKQLELSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDP 663

Human   652 REQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTES 716
            :.:|..|.|..|:.||..||.|..:|.||||:|..::|:.||.:..||:..||.|.....::.||
  Fly   664 QLERQVETIRNLVDSYMKIVTKTTRDMVPKAIMMLIINNAKDFINGELLAHLYASGDQAQMMEES 728

Human   717 EDMAQRRKEAADMLKALQGASQIIAEI 743
            .:.|.||:|...|.:|.:.|.|||.::
  Fly   729 AESATRREEMLRMYRACKDALQIIGDV 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNM1L	NP_001265393.1	DLP_1	23..315	CDD:206738	155/293 (53%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	32..39		4/6 (67%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	58..60		1/1 (100%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	159..162		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	228..231		2/2 (100%)
		Dynamin_M	239..523	CDD:395818	105/292 (36%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	258..261		2/2 (100%)
		Middle domain. /evidence=ECO:0000269\|PubMed:15208300	357..502		52/147 (35%)
		Interaction with GSK3B. /evidence=ECO:0000269\|PubMed:9731200	461..698		68/290 (23%)
		B domain. /evidence=ECO:0000269\|PubMed:15208300	515..582		19/114 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..603		17/113 (15%)
		GED	655..743	CDD:396682	35/87 (40%)
		Important for homodimerization. /evidence=ECO:0000269\|PubMed:23584531	667..681		6/13 (46%)
shi	NP_001259588.1	DYNc	1..240	CDD:197491	147/267 (55%)
		CrfC	73..>498	CDD:223771	191/433 (44%)
		Dynamin_M	212..498	CDD:279383	105/294 (36%)
		PH_dynamin	512..644	CDD:269958	25/145 (17%)
		PH	552..638	CDD:278594	18/99 (18%)
		GED	664..755	CDD:128597	35/90 (39%)
		DUF4527	<758..819	CDD:291689
		Drf_FH1	<761..>846	CDD:283903
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141880at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100232
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720