DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNM1L and fzo

DIOPT Version :9

Sequence 1:	NP_001265393.1	Gene:	DNM1L / 10059	HGNCID:	2973	Length:	749	Species:	Homo sapiens
Sequence 2:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	85/574 - (14%)
Similarity:	177/574 - (30%)	Gaps:	245/574 - (42%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLIL 65
            :|.|....::::.:...:..|.:   ::...|..|:|||:|:.:|:...:||...|
  Fly    65 LEHLCAFSSRVEAIAKVLSRDRM---KVAFFGRTSNGKSAVINALLHEKILPSAMG--------- 117

Human    66 QLVHVSQEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETER 130
                                                      ||.    :.|.:::....||||.
  Fly   118 ------------------------------------------HTT----SCFCQVQANGSNETEH 136

Human   131 ISGNNKGVSPEPIHLKI---------FSPNVV--------------------NLTLVDLPGMTKV 166
            :.     |..|..|:::         .||..:                    ::.|:|.||:
  Fly   137 VK-----VEQEDEHMELSALSQLASAHSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGV--- 193

Human   167 PVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLD 231
                   |:..|:.:.:..:..:.:..||.:.|.:|      ..::.|:...|      |.:||
  Fly   194 -------DVTAQLDDCLDSYCMDADVFILVLNAEST------VSRVERQFFKD------VASKL- 238

Human   232 LMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDI-NNKKSVTDSIRDEYAFLQKKYPSLANRNGT 295
                                       :|..|.| ||:.....|:.          |.:..:...
  Fly   239 ---------------------------SRPNLFILNNRWDKASSLE----------PEMEQKVKD 266

Human   296 KYLARTLNRLL---------------MHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSAT 345
            :::.|.:|.|:               ::|:        :.:..|..:...:.|..|:     :..
  Fly   267 QHMERCVNLLVDELGVYSTAQEAWERIYHV--------SALEALHIRNGQITNPSGQ-----TQQ 318

Human   346 LLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIR 410
            ..|...:|..::.|.:..:|  ::|.               ||..|.|...:  ||.:
  Fly   319 RYQEFLRFENDFSNCLAVSA--LKTK---------------FGPHLLSAQKI--LNQL------- 357

Human   411 NATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVEL---------VHEEMQRIIQHCSNYSTQE 466
                 :..|..|      .:::..:.::|...|...|         :.:|.:..:|:|
  Fly   358 -----KSTLICP------FIEKVSRLIDENKERRANLNAEIEDWLILMQEDREALQYC------- 404

Human   467 LLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLV-AIELAYINTKHPDFADACG 519
               |.:|.:....|..|:|       |:.:..|: :..|::....||:|....|
  Fly   405 ---FEELTEMTQRVGRCVL-------NDQIKTLIPSSVLSFSQPFHPEFPAQIG 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNM1L	NP_001265393.1	DLP_1	23..315	CDD:206738	48/336 (14%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	32..39		3/6 (50%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	58..60		0/1 (0%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	159..162		1/2 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	228..231		1/2 (50%)
		Dynamin_M	239..523	CDD:395818	45/307 (15%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	258..261		0/2 (0%)
		Middle domain. /evidence=ECO:0000269\|PubMed:15208300	357..502		24/154 (16%)
		Interaction with GSK3B. /evidence=ECO:0000269\|PubMed:9731200	461..698		12/60 (20%)
		B domain. /evidence=ECO:0000269\|PubMed:15208300	515..582		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..603
		GED	655..743	CDD:396682
		Important for homodimerization. /evidence=ECO:0000269\|PubMed:23584531	667..681
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	54/382 (14%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900