Protein Alignment DNM1L and Opa1

DIOPT Version :10

• Sequence 1: NP_001265393.1
• Gene: DNM1L / 10059
• HGNCID: 2973
• Length: 749
• Species: Homo sapiens
• Sequence 2: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 156/687 - (22%)
• Similarity: 272/687 - (39%)
• Gaps: 149/687 - (21%)

Human    25 LPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-IVTRRPLILQLV----HVSQEDKRKTTGEEND 84
            ||::||||.|||||:|||||:....:.|||:| ::||.|:.:.|.    ||:|   .:.:..|.|
  Fly   299 LPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQ---FRDSDREYD 360

Human    85 PATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFS 149
                     |:|                 .:|..::|:::|...:......|.||.|.|.:.:..
  Fly   361 ---------LTK-----------------ESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKG 399

Human   150 PNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISR 214
            |.:..:.||||||:......|...|.:..|.::...::||||:|||.:...:.|...|....:..
  Fly   400 PGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVM 464

Human   215 EVDPDGRRTLAVITKLDLMDAGTD---AMDVLMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSI 275
            :.||.||||:.|:||:||.:...|   ...:|.|::.|:| ||...||...    ..|....|:|
  Fly   465 QCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGR----GRKDDSIDAI 525

Human   276 R--DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQ---YQSLLNSY 335
            |  :|..|...|   |.:|.|          ::|.|      ::.:|...||..   ::.:..:.
  Fly   526 RQYEEDFFKNSK---LFHRRG----------VIMPH------QVTSRNLSLAVSDRFWKMVRETI 571

Human   336 GEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGL 400
            .:..|...||...|.|::...:....|.     ...||         |.:..|..|:.|..|..:
  Fly   572 EQQADAFKATRFNLETEWKNNFPRLRES-----GRDEL---------FDKAKGEILDEVVTLSQI 622

Human   401 NTIDILTAIRNATGPR------PALFVP------EVSFELLVKRQIKRLEEPSL--RCVELVHEE 451
            :......|:......:      .::::|      :.||..:|..::::..|.:|  :.||...|.
  Fly   623 SAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEA 687

Human   452 MQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFAD 516
            :|:     ...|..|..:..:.||.|.:      :.:..|.:|.:..         ::......|
  Fly   688 LQQ-----EFISLMERSKKAQDHDGIFD------QLKSAVVDEAIRR---------HSWEDKAID 732

Human   517 ACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETK 581
            ...::..|..|.|.....:|..|||...:||                    .:.||:|  ..||.
  Fly   733 MLRVIQLNTLEDRFVHDKQEWDSAVKFLESS--------------------VNAKLVQ--TEETL 775

Human   582 NVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVA 646
            ....|.|      |.....:|:.:.:..:....:..|..|.:     .....|...|....:...
  Fly   776 AQMFGPG------QMRRITHWQYLTQDQQKRRSVKNELDKIL-----KNDTKHLPTLTHDELTTV 829

Human   647 RKLSAREQRDCEVIERLIKSYFLIVRKN-IQDSVPKA 682
            ||...|:..|.:. :.:.:::|.:.||: :|.::.:|
  Fly   830 RKNLQRDNVDVDT-DYIRQTWFPVYRKHFLQQALQRA 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNM1L	NP_001265393.1	DLP_1	23..315	CDD:206738	90/300 (30%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	32..39		5/6 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	58..60		0/1 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	159..162		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	228..231		2/2 (100%)
		Dynamin_M	238..523	CDD:460033	56/307 (18%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	258..261		1/2 (50%)
		Middle domain. /evidence=ECO:0000269|PubMed:15208300	357..502		26/158 (16%)
		Interaction with GSK3B. /evidence=ECO:0000269|PubMed:9731200	461..698		39/223 (17%)
		B domain. /evidence=ECO:0000269|PubMed:15208300	515..582		15/66 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..603		14/66 (21%)
		GED	653..743	CDD:460495	6/31 (19%)
		Important for homodimerization. /evidence=ECO:0000269|PubMed:23584531	667..681		4/14 (29%)
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	93/324 (29%)
		OPA1_C	629..972	CDD:466080	50/291 (17%)