DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DNM1L and Opa1

DIOPT Version :9

Sequence 1:NP_001265393.1 Gene:DNM1L / 10059 HGNCID:2973 Length:749 Species:Homo sapiens
Sequence 2:NP_725369.1 Gene:Opa1 / 36578 FlyBaseID:FBgn0261276 Length:972 Species:Drosophila melanogaster


Alignment Length:687 Identity:156/687 - (22%)
Similarity:272/687 - (39%) Gaps:149/687 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    25 LPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-IVTRRPLILQLV----HVSQEDKRKTTGEEND 84
            ||::||||.|||||:|||||:....:.|||:| ::||.|:.:.|.    ||:|   .:.:..|.|
  Fly   299 LPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQ---FRDSDREYD 360

Human    85 PATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFS 149
                     |:|                 .:|..::|:::|...:......|.||.|.|.:.:..
  Fly   361 ---------LTK-----------------ESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKG 399

Human   150 PNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISR 214
            |.:..:.||||||:......|...|.:..|.::...::||||:|||.:...:.|...|....:..
  Fly   400 PGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVM 464

Human   215 EVDPDGRRTLAVITKLDLMDAGTD---AMDVLMGRVIPVK-LGIIGVVNRSQLDINNKKSVTDSI 275
            :.||.||||:.|:||:||.:...|   ...:|.|::.|:| ||...||...    ..|....|:|
  Fly   465 QCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGR----GRKDDSIDAI 525

Human   276 R--DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQ---YQSLLNSY 335
            |  :|..|...|   |.:|.|          ::|.|      ::.:|...||..   ::.:..:.
  Fly   526 RQYEEDFFKNSK---LFHRRG----------VIMPH------QVTSRNLSLAVSDRFWKMVRETI 571

Human   336 GEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGL 400
            .:..|...||...|.|::...:....|.     ...||         |.:..|..|:.|..|..:
  Fly   572 EQQADAFKATRFNLETEWKNNFPRLRES-----GRDEL---------FDKAKGEILDEVVTLSQI 622

Human   401 NTIDILTAIRNATGPR------PALFVP------EVSFELLVKRQIKRLEEPSL--RCVELVHEE 451
            :......|:......:      .::::|      :.||..:|..::::..|.:|  :.||...|.
  Fly   623 SAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEA 687

Human   452 MQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFAD 516
            :|:     ...|..|..:..:.||.|.:      :.:..|.:|.:..         ::......|
  Fly   688 LQQ-----EFISLMERSKKAQDHDGIFD------QLKSAVVDEAIRR---------HSWEDKAID 732

Human   517 ACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETK 581
            ...::..|..|.|.....:|..|||...:||                    .:.||:|  ..||.
  Fly   733 MLRVIQLNTLEDRFVHDKQEWDSAVKFLESS--------------------VNAKLVQ--TEETL 775

Human   582 NVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVA 646
            ....|.|      |.....:|:.:.:..:....:..|..|.:     .....|...|....:...
  Fly   776 AQMFGPG------QMRRITHWQYLTQDQQKRRSVKNELDKIL-----KNDTKHLPTLTHDELTTV 829

Human   647 RKLSAREQRDCEVIERLIKSYFLIVRKN-IQDSVPKA 682
            ||...|:..|.:. :.:.:::|.:.||: :|.::.:|
  Fly   830 RKNLQRDNVDVDT-DYIRQTWFPVYRKHFLQQALQRA 865

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNM1LNP_001265393.1 DLP_1 23..315 CDD:206738 90/300 (30%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 32..39 5/6 (83%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 58..60 0/1 (0%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 159..162 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 228..231 2/2 (100%)
Dynamin_M 239..523 CDD:395818 55/303 (18%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 258..261 1/2 (50%)
Middle domain. /evidence=ECO:0000269|PubMed:15208300 357..502 26/158 (16%)
Interaction with GSK3B. /evidence=ECO:0000269|PubMed:9731200 461..698 39/223 (17%)
B domain. /evidence=ECO:0000269|PubMed:15208300 515..582 15/66 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 536..603 14/66 (21%)
GED 655..743 CDD:396682 6/29 (21%)
Important for homodimerization. /evidence=ECO:0000269|PubMed:23584531 667..681 4/14 (29%)
Opa1NP_725369.1 DLP_1 298..572 CDD:206738 93/324 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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