Protein Alignment ABCC5 and l(2)03659

DIOPT Version :10

• Sequence 1: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Sequence 2: NP_610482.3
• Gene: l(2)03659 / 47905
• FlyBaseID: FBgn0010549
• Length: 1374
• Species: Drosophila melanogaster
• Alignment Length: 1499
• Identity: 458/1499 - (30%)
• Similarity: 739/1499 - (49%)
• Gaps: 221/1499 - (14%)

Human    15 PGYRSVRERTSTS-----------GTHRDREDS-KFRRTRPLECQDALETAARAEGLSLDASMHS 67
            |.:.||.||.:||           ..||::::| ....:.||.|:...|...:.|......:::|
  Fly     9 PTFDSVSERENTSIEESSLLENNGFDHRNKDESLSVNTSPPLVCRKCFELGHQTENCKQKLTVNS 73

Human    68 QLRILDEEHPKGKYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMED 132
            :......|..|         :.|       ::|...:...|.:.|.:...:.|..::| .|...|
  Fly    74 ENNSAQNEKEK---------VLP-------ENPRARSNFISSLCFWYTIPIFRKGYRK-TLDSTD 121

Human   133 VWSLSKHESSDVNCRRLERLWQEELNEVGPDAASLRRVV----WIFCRTRLILSIVCLMITQLAG 193
            ::...:.:.||:...||...|:.||...|...:.:|.::    |......|.:.:|.|.:..|.
  Fly   122 LYRPLEEQKSDILGNRLCASWERELKNDGRSPSLVRALLRVFGWQLGFPGLAIFVVELGLRTLQ- 185

Human   194 FSGPAFMVKHLLEY----TQATESNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAI 254
               |.|:|| |:.|    ..|..:...|::..::...||.::.:   ..|:.::: ...::|.|:
  Fly   186 ---PIFLVK-LISYFSGEPDAANAGFYYAVAQIVISALTVMILT---PTTFGIHH-VCFKMRVAM 242

Human   255 LTMAFKKILKLKN--IKEKSLGELINICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIIL 315
            .:|.|:|.|:|..  :.:.:.|.::|:.|||..|:..|......|..||  |:.|..::|..|
  Fly   243 GSMIFRKALRLTKGALGDTTSGHVVNLISNDIPRLDSAPYTVHYLWVGPLQVLVITYLMYQEI-- 305

Human   316 GPTGFLGSAVFILFYPAMMFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQS 380
            |.:...|....:||.|..|:....|:..:.|....||.|::.:||:::.|:.:|||||.:.|.|.
  Fly   306 GISAVFGVLFMLLFMPIQMYLGTRTSAIQLKAAERTDNRIRMVNEIISAIQVLKMYAWEQPFEQM 370

Human   381 VQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTF 445
            |...||:|...:.:..|.:........::..:|..::...::.||...|...||.:...:|.:..
  Fly   371 VTHAREKEMNTIRQGQYIRGFDFARRIVLSRVAIFLSLVGYVILGKVFTPEIAFMITAYYNVLLA 435

Human   446 ALKV-TPFSVKSLSEASVAVDRFKSLFLMEEV-----------HMIKNKPASPHIKIEMKNATLA 498
            |:.: .|.::...::...::.|.:.....||:           ..:...|.|.:.:.::..:.::
  Fly   436 AMSIYVPSAIIQTAQFLTSIRRVEQFMQSEELGSSDKSEGPSKDTVPGNPPSNNNEADLLKSAIS 500

Human   499 -------WDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDER 556
                   ||      .|||
  Fly   501 IRDLKAKWD------PNSP---------------------------------------------- 513

Human   557 PSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAI 621
                              ..||..|:|||:.|.:|.:.|..||||:|||.||||::....|.:.:
  Fly   514 ------------------DYTLSGINLEIKPGSVVAVIGLTGSGKSSLIQAILGELKANSGQLQV 560

Human   622 SGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLS 686
            :|:.:|.:|::|:.:.|:|.|||||:..|.:||..|:..|.|..|..:||..|.|.:|||||.||
  Fly   561 NGSLSYTSQESWLFSGTVRQNILFGQPMDSQRYEEVVKKCALERDFDLLPLRDNTIVGERGATLS 625

Human   687 GGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCD 751
            |||:.||||||::|...|||:|||||||:||.|..|:|:..:|.||:..||:.||||.|:|...|
  Fly   626 GGQKARISLARSVYRKASIYLLDDPLSAVDASVARHLFDQCVRGHLRGSTVVLVTHQEQFLPHVD 690

Human   752 EVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLG-------------ETPPVEINS---KKET 800
            :::.:..|.|...|.:|.|:.         ..|:.|             |..|:.:||   |.|.
  Fly   691 QIVILANGQIKALGDYESLLK---------TGLITGLGSLSKTDKAKTEEQEPLNLNSPDNKNEV 746

Human   801 SGSQKKSQDK--GPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIM 863
            :..::.|:..  |..:|   ||           .:|.:..|.:..::|..|.||.||.:||||::
  Fly   747 TPIKENSEQTVGGSSSG---KE-----------HVERQESGGISLALYRKYFQAGGGLVAFLVML 797

Human   864 ALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLIL 928
            :..:|...:.....::|:||:|:.|     |......:.|  .::..|..|.  |.|.:.:.:|:
  Fly   798 SSSVLAQVAVTGGDYFLTYWVKKES-----TAAGHGEMED--MESKSMDVYK--YTLIIILSVIM 853

Human   929 KAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLP------ 987
            ......:......:||.|||:.:|.|:.|:.|.||.....|.|||||:|||.:||..||
  Fly   854 NLSSSFLLFNIAKKASIRLHNTIFNRVTRADMHFFSINKHGSILNRFTKDMSQVDEVLPVVLVDV 918

Human   988 FQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLS 1052
            .|..:::..:|:|      ||.|.|..||....|.::|..|..:.....|:|||::.|.:||..|
  Fly   919 MQIALWLAGIIIV------IANVNPLLLVPTLMLSVIFYHLRNLYLKTSRDLKRVEAINRSPVYS 977

Human  1053 HITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMI 1117
            |:.:|:.||.||.|.:..:.....:....|.:.:.||::....:.....::.|.:..|:    :|
  Fly   978 HLAASLNGLTTIRALDAQRVLEKEFDSYQDAHSSAFFMYISTSQAFGYCMNCICVIYIS----II 1038

Human  1118 VLMHGQIPP---AYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS----LEAP 1175
            .|.....||   |..||.|:.|:.|..:.|:.||..:|.|...|:|||:..| :::.    ||||
  Fly  1039 TLSFFAFPPGNGADVGLVITQAMGLIDMVQWGVRQTAELENTMTAVERVVEY-ESIEPEGMLEAP 1102

Human  1176 ARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL--VLKKVSFTIKPKEKIGIVGRTGSGKSSLGM 1238
               .:|.|...||::||:.|:...:||..|...  |||.:||.|:|:||:|||||||:|||||..
  Fly  1103 ---DDKKPPKTWPEQGEIIFKELNLRYTPNAKAENVLKSLSFVIQPREKVGIVGRTGAGKSSLIN 1164

Human  1239 ALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDAL 1303
            ||||| ..:.|.:.||......:||.|||.::|||||||||||||:|.|||||::|:::::|..|
  Fly  1165 ALFRL-SYTDGSVLIDTRDTRQMGLHDLRRQISIIPQEPVLFSGTMRYNLDPFDEYSDEKLWGCL 1228

Human  1304 ERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLI 1368
            |...:||.::.||..|.|::.|.|.|||||:|||:|:|||:||..:||::|||||.:|.:||.||
  Fly  1229 EEVKLKEVVSDLPDGLASKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLI 1293

Human  1369 QETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENKV 1433
            |.|||..|.|||:|||||||||::.||::||:..|:||||.:|..|::...|:.:........:.
  Fly  1294 QATIRSKFRDCTVLTIAHRLHTIIDSDKVMVMDAGRVVEFGSPYELMTKSDSKVFHNLVNQSGRA 1358

Human  1434 AVKG 1437
            :.:|
  Fly  1359 SYEG 1362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41		10/37 (27%)
		PLN03130	100..1425	CDD:215595	438/1388 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		3/36 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		9/37 (24%)
l(2)03659	NP_610482.3	PLN03130	83..1369	CDD:215595	441/1425 (31%)