Protein Alignment ABCC5 and CG11898

DIOPT Version :10

• Sequence 1: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Sequence 2: NP_651679.2
• Gene: CG11898 / 43451
• FlyBaseID: FBgn0039645
• Length: 1320
• Species: Drosophila melanogaster
• Alignment Length: 1376
• Identity: 431/1376 - (31%)
• Similarity: 688/1376 - (50%)
• Gaps: 170/1376 - (12%)

Human    96 KHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKH-ESSDVNCRRLERLWQEELNE 159
            :..:||..|..||...|.|...:. |...:..|...|::..... ||:.|:...|.. |::||..
  Fly     8 RQPNPVTKANFFSKWFFIWTREIL-VKGLQRNLDPSDLYETEPSLESTQVSSFLLGH-WEQELKR 70

Human   160 VGPDAASLRRVV----WIFCRTRLILSIVCLMI--TQLAGFSGPAFMVKHLLEYTQATESNLQYS 218
            ..|:.  ||.:.    |.|....::.||:.:.:  ||.....|   :|....|.|.....:..|
  Fly    71 SKPNV--LRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGG---LVSFFSESTGKITKHSAY- 129

Human   219 LLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKS--LGELINICS 281
             |..:|::|..::............:|.|.|:|.|...:.::|.|::....:.|  .|..|::.:
  Fly   130 -LYAMGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMA 193

Human   282 NDGQRMFEAAAVGSLLAGGPV--VAILGMIYNVIILGPTGFLGSAVFILFYPAMMFASRLTAYFR 344
            .|.....|:......|..||:  |..:.:||.:|  |....:|....:.|.|...:|:|..|.::
  Fly   194 TDLPTFNESFYCFHELWRGPLEGVVFVYIIYQLI--GWPAVVGLGTIVAFIPLQAWAARAIARYK 256

Human   345 RKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQS--ITVGVAP 407
            |......||||:.|||::..::.||||||.|:|::.:.|:|:||...:..:.|..:  ...|:..
  Fly   257 RSSADVGDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGLQCTGMIS 321

Human   408 IVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVT-PFSVKSLSEASVAVDRFKSLF 471
            .:.:..|:||:   :..|..:|:.:.|.|.:.::.:..:|..: |.::....|..|..:|.|...
  Fly   322 KLSLFLSLVTY---VFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFL 383

Human   472 LMEE------VHMIKNKPASPH----------IKIEMKNATL-----AWDSSHSSIQNSPKLTPK 515
            ...|      ||..|....:|.          .|.|:|:.|:     :||.
  Fly   384 FQHENPADGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQ-------------- 434

Human   516 MKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHS 580
                                                        :::|.:|.|         :..
  Fly   435 --------------------------------------------KKQEKRHRH---------IED 446

Human   581 IDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILF 645
            :..:.|:.:.|||.|:||:||::|:..|||::.::.||:.::|..:|..|:.|:|..:|||||||
  Fly   447 VSFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILF 511

Human   646 GKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDD 710
            .:.|||:||..||..|.|..|:..||..|.|.:||.||:|||||:.|:|||||:|....||:|||
  Fly   512 TEPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDD 576

Human   711 PLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNG 775
            ||||:|:||...:.:..:.:.|..|..:.|||::|.|...|.::.::.|.|:.:|.::.|..|..
  Fly   577 PLSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDALKKLIR 641

Human   776 DYATIFNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGS 840
            ...::.|::.:.:...:..:|..|....:|          |:.:|:.:...|.:....|::..||
  Fly   642 FRMSVANDVEVAKLRAMRTDSVYEEPEPRK----------SLSQEEHMDRHEIEQQFKEQQQIGS 696

Human   841 VPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSM 905
            |....|..|.:..|.||..::|:.:|::...|.|....:||.|          ....||   :..
  Fly   697 VKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKW----------ATWEET---EPN 748

Human   906 KDNPHMQYYAS------IYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFD 964
            :..|..:|:.:      :|...:...||...:|...|...|||.|.|:||:||:.::|:.|.||.
  Fly   749 QHEPIPEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFT 813

Human   965 TTPTGRILNRFSKDMDEVDVRLPFQAEM----FIQNVILVFFCVGMIAGVFPWFLVAVGPLVILF 1025
            ...:||||||||.|:..:||.|| ||.|    |..|.:.|   :.:::....|.|:   |..::.
  Fly   814 LATSGRILNRFSSDVLAIDVNLP-QAMMDSIEFAVNALAV---LAVVSTANIWLLI---PATVVV 871

Human  1026 SVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFL----HRYQELLDD 1083
            ::|:....:.|   |.|||::.|::||..||..::.:|||||.|.| |.:::    |.||   ::
  Fly   872 ALLYGCRCLYIGASRSLKRIETISRSPIYSHTNATFKGLATIRALN-GTKYMERDFHYYQ---NE 932

Human  1084 NQAPFFLFTCAMRWLAVRLDLISI--ALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFT 1146
            |.:..:|.....|..|...|||.:  .|..|...::...|........||||:.:::|..:.|..
  Fly   933 NTSALYLHVSINRAFAFWTDLICVLYILAVTFSFLLFDKHRGYYSGDVGLAITQSMKLVLMCQAG 997

Human  1147 VRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPLVLK 1211
            :|...|.|...|||||:..|:...|..|....::......||..|::.|.:..:||..:.|.:||
  Fly   998 MRQTVELENMMTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGPYILK 1062

Human  1212 KVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQE 1276
            .::|||:.:|||||||.|.:||||:..|||||..::|. |.|||...|.:||.|||.::|||||:
  Fly  1063 GLTFTIRGEEKIGIVGHTAAGKSSIVHALFRLAHINGH-ISIDGFETSQLGLHDLRRRISIIPQD 1126

Human  1277 PVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIA 1341
            ||||||::|.|||||.:.|::::|.|||...:||.::.|...:...:.:.|.|||:|:|||:|:|
  Fly  1127 PVLFSGSLRFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLA 1191

Human  1342 RALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVV 1406
            |||||..||||:|||||.:|.|||.||||.|...||.||:||||||||||:.:||:||:..|:||
  Fly  1192 RALLRQNKILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVV 1256

Human  1407 EFDTPSVLLSN 1417
            |...|..||.|
  Fly  1257 ELGHPHELLHN 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	431/1372 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		0/36 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		5/32 (16%)
CG11898	NP_651679.2	MRP_assoc_pro	2..1268	CDD:188098	431/1376 (31%)