Protein Alignment ABCC5 and rdog

DIOPT Version :10

• Sequence 1: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Sequence 2: NP_651678.1
• Gene: rdog / 43450
• FlyBaseID: FBgn0039644
• Length: 1374
• Species: Drosophila melanogaster
• Alignment Length: 1426
• Identity: 476/1426 - (33%)
• Similarity: 738/1426 - (51%)
• Gaps: 172/1426 - (12%)

Human    92 RTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEE 156
            |...:.::|...|..||..:|.|:..|.: ...:|.|:.|:::...|...|:....:...||::|
  Fly     6 RKVVRPKNPFTKANFFSQWSFWWMRDLFK-RGLQGPLTDEELYQHRKTLDSERVTNKFAELWEDE 69

Human   157 LNEVGPDAAS--LRRVVWIFCRTRLILSI---VC--LMITQLAGFSGPAFMVKHLLEY--TQATE 212
            |....|....  ||....||....|..||   :|  ||...|.|..|          |  |..|:
  Fly    70 LKRSNPSVVRMILRAYGKIFVPMGLAFSISETICKSLMPLFLGGLVG----------YFATNQTD 124

Human   213 SNLQYSLLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKL-KNIKEKSL-GE 275
            .:...:.|..:|:::..:|...:........::.|.:||.|:..:.::|:|:: |:.....| |.
  Fly   125 ISENTAYLYAMGIVICMLVPVITFHPFIFYIFQVGTKLRLALSGLIYRKVLQVSKSSSNDGLRGR 189

Human   276 LINICSNDGQRMFEAAAVGSLLAGGPVVAIL--GMIYNVIILGPTGFLGSAVFILFYPAMMFASR 338
            .|||.|||..|...|.........||:.:||  .::|..|  |.:..:|.:..:.|.|...:|::
  Fly   190 AINILSNDLGRFDVALCFLHDTWKGPMESILIGFLMYREI--GISAVIGVSFMLSFIPLQAWAAK 252

Human   339 LTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQS--- 400
            ..||:|:.....||.||:.|||::..|:.||||||.|:|::.:.::|.:|.:.:....|..:
  Fly   253 KAAYYRQMTAERTDMRVKLMNEIIQGIQVIKMYAWEKSFARVIAEVRLKEVKAIRGTAYIHAALG 317

Human   401 ITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVT--PFSVKSLSEASVA 463
            .|..::|:.|.:|    ...::.||..|||.:.:||.:.||.:..:: ||  |.|:..::||.|:
  Fly   318 CTSMISPLSVFLA----LCSYVYLGDPLTAQKVYTVSSYFNMLNDSM-VTFWPMSITFIAEALVS 377

Human   464 VDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKE 528
            ..|.|. ||::      ...|...|.:|....|                    .|:|| ...||:
  Fly   378 AKRCKD-FLLD------GDKAEVPINLEANQQT--------------------GKNKR-KISKKD 414

Human   529 KVRQLQRTEHQAVLAEQKGH--LLLDSDERPSPEEEEGKHIHL------GHLRLQRTLHSIDLEI 585
            |.:.::.  :.::|:..:.|  .|.|.|...:.:....|::..      ||...  .:.....:|
  Fly   415 KQKNVEL--NGSLLSNGQVHHNRLRDYDPEATKKCVVLKNVSASWDTSDGHANC--AIEDFSTDI 475

Human   586 QEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYD 650
            ::..|..:.|.||:||:|.::.:||::.:.:|...:.|..:|.:|::|:...|:||||:|.::|:
  Fly   476 KDQTLAAVVGPVGAGKSSFLNVLLGEVGIDKGEAMVHGKISYASQESWVFEGTIRDNIVFVEDYN 540

Human   651 EERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSAL 715
            |.||..|:..|.|..|:.:||..|||.:||||.:|||||:.|:|||||:|....||:|||||||:
  Fly   541 ERRYKKVVKVCGLERDMELLPRGDLTVVGERGVSLSGGQKARVSLARAVYRKADIYLLDDPLSAV 605

Human   716 DAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATI 780
            |.|||.|||:..||..|.:|..:.||||:|||.|.:.::.|..|.|..:|:::||.
  Fly   606 DTHVGKHIFDRCIRDFLSNKIRILVTHQVQYLFDVEHLLLMGSGKIMAQGSYQELQ--------- 661

Human   781 FNNLLLGETPPVEINSKKETSGSQKKSQDKGPKTGSVK-------KEKAVKPEEGQL-------- 830
                          .|::.....|.:..:.|..|.||.       .||:::.:..||
  Fly   662 --------------RSRQFQFLEQTQHDESGIDTHSVSSYLSRSDSEKSMEHQHNQLLRPDEHVE 712

Human   831 -VQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALF----MLNVGSTAFSTWWLSYWIKQGSGN 890
             |..|::..||:...||..||:|........::::||    ::..|...|.:.|: .|.:|.:.|
  Fly   713 DVNQEQQTVGSIKMHVYASYIKALDSTFLLGIVISLFVCARIMLTGVDYFLSRWV-IWEEQIAVN 776

Human   891 TTVTRGNETS---VSDSMKDNPHMQYYASI----------------YALSMAVMLILKAIRGVVF 936
            .|.|..|||.   .:|::..|....|.|.:                ||..:...||:..||...|
  Fly   777 RTTTLLNETDTTIANDTLPINATDPYIAPLLASDIQAGIRQELVLFYATILGATLIVYLIRTFGF 841

Human   937 VKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVF 1001
            .|..||.|..|||.|||.|.|:.|.||:|..:||||||||||:..||..||......:..:|.|.
  Fly   842 FKMCLRISLHLHDRLFRGITRASMYFFNTNSSGRILNRFSKDIRTVDTDLPHTLLDCLAFIIDVS 906

Human  1002 FCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLAT 1063
            ..|.::|....|.|:   |..|:..:|.::..:.:   |.:|||::|::||..|....:.|||.|
  Fly   907 GVVIIVAIANYWLLI---PAAIIGVILGMIRYLYVNTSRSVKRLESISRSPVFSLTNQTFQGLTT 968

Human  1064 IHAYNK----GQEFLHRYQELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQI 1124
            |.|...    .||| |.||   :.|.:.:|||....|..|:..|::.|..:|......:|:..:.
  Fly   969 IRALQAQSALEQEF-HEYQ---NTNTSAWFLFLSCTRAFALWSDVLCIVYMTAVTFSFLLLKDEF 1029

Human  1125 PPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLS---LEAPARIKNKAPSPD 1186
            .....||||.::..:||:.|:.:|..:|.|.:.|||||:..|.:..|   ||.|.:.|   |..:
  Fly  1030 DSGDVGLAILHSTTMTGMCQWGMRQTAELENQMTSVERVLEYTEQPSEALLETPEKFK---PKSE 1091

Human  1187 WPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCI 1251
            ||.:|.:.|.|.::||......|||.::|||:|:||||||||||:||||:..::|||. .:.|.|
  Fly  1092 WPSKGRIEFINFKLRYSPKEAPVLKDLNFTIEPREKIGIVGRTGAGKSSIIQSIFRLA-CNEGMI 1155

Human  1252 KIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLP 1316
            :||.|.|..|||.||||::|||||:|||||||:|.||||.::.:::::|.||....::..::.|.
  Fly  1156 RIDDVDIEHIGLHDLRSQVSIIPQDPVLFSGTLRYNLDPMDERSDEEMWKALGDVELRSYVSTLI 1220

Human  1317 LKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTM 1381
            ..|...:.:.|.|||||:|||:|:|||:|||.||||:|||||.:|.|||.|||:|||..||.||:
  Fly  1221 GGLNCRMYDGGSNFSVGQRQLVCLARAILRHNKILIMDEATANVDPETDKLIQQTIRSKFAHCTV 1285

Human  1382 LTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLL------------SNDSSRFYAMFAAAE 1430
            ||||||||||:.|||::|:..|:|.|...|..||            :..::..:|:..|||
  Fly  1286 LTIAHRLHTVMDSDRVLVMDAGEVRELGHPYELLQRTGGYLRQLVDNTGAATSFALQQAAE 1346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	471/1411 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		8/39 (21%)
rdog	NP_651678.1	MRP_assoc_pro	14..1323	CDD:188098	471/1393 (34%)