Protein Alignment ABCC5 and Mrp5

DIOPT Version :10

• Sequence 1: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Sequence 2: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Alignment Length: 1378
• Identity: 461/1378 - (33%)
• Similarity: 744/1378 - (53%)
• Gaps: 128/1378 - (9%)

Human    98 QHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW-SLSKHESSDVNCRRLERLWQEELNEVG 161
            ::|.:.:.:||.:.|.:.........|| .|...|:: :|.:|.|..:. .:|...|::|:.:..
  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKK-TLDENDLYRALQEHRSDHLG-SKLSAAWEKEVEKKR 73

Human   162 PD-------AASLRRVVWIFCRTRLILSI--VCLMITQLAGFSGPAFMVKHLLEYTQATE---SN 214
            ..       .||:....|......|:|.|  :...:||      |.|:...:..|..|:.   .|
  Fly    74 KKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ------PLFLGGLVAYYADASNQEGDN 132

Human   215 LQYSLLLVLGLLLTE-----IVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEKS 272
            ...:.|..||::||.     .:..:.|.:     :..|::.|.|:.:|.::|.|:|..  :.:.:
  Fly   133 QTKAYLYALGVILTSACNVLFMHPYMLGM-----FHIGMKARIAMTSMIYRKALRLSRTALGDTT 192

Human   273 LGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVII--LGPTGFLGSAVFILFYPAMMF 335
            :|:::|:.|||..|:..:....:.|..|||.  :|:|..::.  :|.:.|.|.||.:||.|...:
  Fly   193 IGQVVNLISNDVGRLDVSVIHMNYLWLGPVE--IGIITYLMYREIGISAFFGVAVMLLFIPLQAY 255

Human   336 ASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGY--- 397
            ..:.|:..|.|....|||||:.|||:::.|:.||||||...||:.:..:|.:|...:....|
  Fly   256 LGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG 320

Human   398 -FQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKV-TPFSVKSLSEA 460
             .||..:.|..|.|.: |:|.|   :.||..|||.:||.:...:|.:...:.| .|..:...:|.
  Fly   321 TLQSFIMFVTRISVFV-SLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAEL 381

Human   461 SVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRG 525
            .|::.|.::..|.||.   |.:..|..:. |.|.......:..:..|.:..|.|..::...|
  Fly   382 LVSIRRIQTFMLHEET---KVRDKSEDLD-EQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEA--- 439

Human   526 KKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKL 590
                       ||..|:::.|...    |::                ....||.:|.|:.:..:|
  Fly   440 -----------EHSIVISKLKAKW----DQK----------------NTDNTLDNISLKFKPRQL 473

Human   591 VGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYN 655
            |.:.|.|||||:|||.|:||::....||:.::||.:|.:|:.|:...|:|.|||||...|:.||.
  Fly   474 VAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYR 538

Human   656 SVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVG 720
            :|:..|.|..|..:||.:|.|.:|||||:|||||:.|||||||:|....||:|||||||:|.|||
  Fly   539 TVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVG 603

Human   721 NHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLL 785
            .|:|:..:|..|:.:.||.||||||:|...|.::.|.:|.|:..||:|.:.....|:|.:..:..
  Fly   604 RHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPS 668

Human   786 LGETPPVEINSKKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEEKGQGSVPWSVYGVYI 850
            ..:....:...||..|....|.:|:.....|::........|..:...|.:.:|.:...:|..|.
  Fly   669 KKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYF 733

Human   851 QAAGGPLAFLVIMALFMLNVGSTAFSTW---WLSYWI-KQGSG--NTTVTRGN----ETSVSDSM 905
            .|.|  ....::.|.|.  :|:...::.   :||||: |.|..  :|.:.|..    ||.: ::.
  Fly   734 GANG--YGLFIVFAFFC--IGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRI-NAD 793

Human   906 KDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGR 970
            .|...:.|:..|   :::| :|...:|.::|....:|:|:.||:.:|:.:.|:.|.||:|.|:||
  Fly   794 TDPVDIYYFTGI---NVSV-IIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGR 854

Human   971 ILNRFSKDMDEVDVRLPF----QAEMFIQNV-ILVFFCVGMIAGVFPWFLVAVGPLVILFSVLHI 1030
            ||||||||:.:||..||.    ..::|:..| |:|..|:     :..|:::|...|||:|.:|.:
  Fly   855 ILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI-----INVWYILATVFLVIVFYLLRV 914

Human  1031 VSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAM 1095
            ......|::|||:.:|:||..||:::|:.|||||.|:...:|.:..:....|.:.:.:::|....
  Fly   915 FYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATS 979

Human  1096 RWLAVRLDLISIALITTTGLMIVLMH----GQIPPAYAGLAISYAVQLTGLFQFTVRLASETEAR 1156
            |.....||.:.:..|....|...|..    |.:     ||||:.|:.:||:.|:.:|.::|.|..
  Fly   980 RAFGYWLDCVCVVYIAVITLSFFLFSPENGGDV-----GLAITQAMGMTGMVQWGMRQSAELENT 1039

Human  1157 FTSVERINHYIKTLSLEAPARIK-NKAPSPDWPQEGEVTFENAEMRY--RENLPLVLKKVSFTIK 1218
            .|:|||:..| :.|..|.....| ||.|..|||::|::.|::..::|  .:....||:.::..|:
  Fly  1040 MTAVERVVEY-EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIE 1103

Human  1219 PKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGT 1283
            ..||:|||||||:|||||..||||| ..:.|.|.||....:|:||.|||||:|||||||||||||
  Fly  1104 GCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGT 1167

Human  1284 VRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHC 1348
            :|.|||||::|::.::|::||...:|:.:|.||..|:|::.|.|.|||||:|||:|:|||:||..
  Fly  1168 MRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILREN 1232

Human  1349 KILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSV 1413
            :||::|||||.:|.:||.|||.|||..|.|||:||||||||||:.||:::|:..|:.|||.:|..
  Fly  1233 RILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFE 1297

Human  1414 LLSNDSSR-FYAM 1425
            ||:....: |::|
  Fly  1298 LLTTSEKKVFHSM 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	460/1374 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		4/36 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		6/32 (19%)
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	447/1308 (34%)