DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ABCC5 and MRP

DIOPT Version :9

Sequence 1:NP_005679.2 Gene:ABCC5 / 10057 HGNCID:56 Length:1437 Species:Homo sapiens
Sequence 2:NP_723772.2 Gene:MRP / 34686 FlyBaseID:FBgn0032456 Length:1549 Species:Drosophila melanogaster


Alignment Length:1454 Identity:496/1454 - (34%)
Similarity:752/1454 - (51%) Gaps:235/1454 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    80 KYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDV 144
            ||..|           :::.|..:|...|.:|:.|...:|...: :..|..:|:|.|...:|   
  Fly   216 KYQRG-----------ENEIPELSASFLSRITYQWFDKMALKGY-RNPLEEKDLWDLRPQDS--- 265

Human   145 NCRRLERLWQEELNE-----------VGPDA-----------------------ASLRRVVWIFC 175
             |..:..::....|:           |.|.|                       ||:...::...
  Fly   266 -CSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSF 329

Human   176 RTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW 240
            ....:...:..:.|....|:.|. ::..::.:.:|.::..::.     |:|...::...:.|.|:
  Fly   330 GGVFLFGALMKLFTDTLTFAQPQ-VLSLIISFVEAQDAEPEWK-----GILYAVLLFVLAAAQTF 388

Human   241 ALN------YRTGVRLRGAILTMAFKKILKLKNI--KEKSLGELINICSNDGQRMFEAAAVGSLL 297
            .|.      :..|:|:|.|::...::|.|::.|.  ||.::||::|:.:.|.||..|.....:::
  Fly   389 ILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMI 453

Human   298 AGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM-MFASRLTAYFRRKCVAATDERVQKMNEV 361
            ...|:...|.:.:....|||:...|.||.|:..|.. :.|||:..|..|: :...||||:.||||
  Fly   454 WSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQ-MKYKDERVKLMNEV 517

Human   362 LTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQ---SITVGVAPIVVVIASVVTFSVHM- 422
            |:.||.:|:|||..:|.:.|..||::|...|....|..   |.....||.:|   |:|||:.:: 
  Fly   518 LSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV---SLVTFATYVL 579

Human   423 -TLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV--HMIKNKPA 484
             :....|:..:....:.:|:.|...|.:.|.....::|..|:|:|.......||:  :.:.:..:
  Fly   580 TSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSS 644

Human   485 SPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHL 549
            .|| .:.::|...:|                                                  
  Fly   645 KPH-PMSIENGEFSW-------------------------------------------------- 658

Human   550 LLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614
                          |..|         ||.:|::|:::|.||.:.|:|||||:|::.|.||:|..
  Fly   659 --------------GDEI---------TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEK 700

Human   615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIG 679
            |.|.:...|..|||.|||||.|||:|||||||:.||.:|||.|:::|.||.|:.||.:.||||||
  Fly   701 LAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIG 765

Human   680 ERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAI--RKHLKSKTVLFVTH 742
            |:|.||||||:||||||||:|||..:|:|||||||:|||||.|||...|  :..|..|:.:.|||
  Fly   766 EKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTH 830

Human   743 QLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYAT-IFNNLLLGETPPVEINSKK-------- 798
            .:.:|...|.:..:|.|.|:|.||.::|:...|.:|. |..:|..|.....|:|..|        
  Fly   831 GVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTAD 895

Human   799 --ETSGSQKK-------------------------------------SQDKGPKTGSVKKEKAVK 824
              |..|:.:|                                     |.|......|:||::.| 
  Fly   896 VPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEV- 959

Human   825 PEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF---STWWLSYWIKQ 886
              ||:|::.|:...|.|.::||..||::.|   .||.: |..:||....||   |..||:.|   
  Fly   960 --EGKLIETEKSQTGGVEFAVYKHYIKSVG---IFLSV-ATLVLNFVFQAFQIGSNLWLTQW--- 1015

Human   887 GSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDEL 951
             :.:..|  .|:|.:.|         .|..:|........:|.....|:...|..:|:..:|:||
  Fly  1016 -ANDQNV--ANDTGLRD---------MYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNEL 1068

Human   952 FRRILR-SPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFL 1015
            ...|:| |..:|||.||.||:||.||.|||.||..||...:.|:..:.:|...:.:|:...|.||
  Fly  1069 LAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL 1133

Human  1016 VAVGPLVILFSVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRY 1077
            ..:.|:..|:   :...|..:   |:|.||:::::||..||.:.::.|.:||.|||.|..|:...
  Fly  1134 AVIVPIAFLY---YFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEES 1195

Human  1078 QELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGL 1142
            ...:|.||...:....|.||||:||:::...:|....|..|| .||..|...||::|||:|:|..
  Fly  1196 DAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQT 1259

Human  1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSP-DWPQEGEVTFENAEMRYRENL 1206
            ..:.||::|:.|....|||||..|.:| ..|||..::.....| :|||||.|.|:|.::||||.|
  Fly  1260 LNWLVRMSSDIETNIVSVERIKEYGET-KQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGL 1323

Human  1207 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLS 1271
            .|||:.|||.|:..||:|||||||:|||||.:||||::|.:||.|.||||.|:.:||..|||:|:
  Fly  1324 DLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLT 1388

Human  1272 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1336
            ||||:||||||::|.|||||...|:|:||.|||.:|:|..:..|...|..|:.|.|:|.|||:||
  Fly  1389 IIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQ 1453

Human  1337 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1401
            |:|:||||||..|:|:|||||||:|.|||.|||:|||..|.:||:|||||||:|:|.||:::||.
  Fly  1454 LVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLD 1518

Human  1402 QGQVVEFDTPSVLLSNDSSRFYAM 1425
            :||::||.:|:.||.|..|.||:|
  Fly  1519 KGQIIEFASPTELLDNPKSAFYSM 1542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ABCC5NP_005679.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..41
CFTR_protein 100..1430 CDD:273530 493/1434 (34%)
ABC_membrane <271..447 CDD:294371 55/181 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..538 0/36 (0%)
ABCC_MRP_domain1 577..759 CDD:213217 101/183 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 794..827 11/79 (14%)
ABC_membrane 863..1143 CDD:294371 92/286 (32%)
ABCC_MRP_domain2 1191..1411 CDD:213211 132/219 (60%)
MRPNP_723772.2 MRP_assoc_pro 14..1548 CDD:188098 496/1454 (34%)
ABC_membrane 338..601 CDD:279056 72/272 (26%)
ABCC_MRP_domain1 649..848 CDD:213217 105/271 (39%)
ABC_membrane 988..1260 CDD:279056 94/291 (32%)
ABCC_MRP_domain2 1308..1528 CDD:213211 132/219 (60%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151527
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.660

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