Protein Alignment ABCC5 and MRP

DIOPT Version :10

• Sequence 1: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Sequence 2: NP_723772.2
• Gene: MRP / 34686
• FlyBaseID: FBgn0032456
• Length: 1549
• Species: Drosophila melanogaster
• Alignment Length: 1454
• Identity: 496/1454 - (34%)
• Similarity: 752/1454 - (51%)
• Gaps: 235/1454 - (16%)

Human    80 KYHHGLSALKPIRTTSKHQHPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDV 144
            ||..|           :::.|..:|...|.:|:.|...:|...: :..|..:|:|.|...:|
  Fly   216 KYQRG-----------ENEIPELSASFLSRITYQWFDKMALKGY-RNPLEEKDLWDLRPQDS--- 265

Human   145 NCRRLERLWQEELNE-----------VGPDA-----------------------ASLRRVVWIFC 175
             |..:..::....|:           |.|.|                       ||:...::...
  Fly   266 -CSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSF 329

Human   176 RTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLLTEIVRSWSLALTW 240
            ....:...:..:.|....|:.|. ::..::.:.:|.::..::.     |:|...::...:.|.|:
  Fly   330 GGVFLFGALMKLFTDTLTFAQPQ-VLSLIISFVEAQDAEPEWK-----GILYAVLLFVLAAAQTF 388

Human   241 ALN------YRTGVRLRGAILTMAFKKILKLKNI--KEKSLGELINICSNDGQRMFEAAAVGSLL 297
            .|.      :..|:|:|.|::...::|.|::.|.  ||.::||::|:.:.|.||..|.....:::
  Fly   389 ILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMI 453

Human   298 AGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM-MFASRLTAYFRRKCVAATDERVQKMNEV 361
            ...|:...|.:.:....|||:...|.||.|:..|.. :.|||:..|..|: :...||||:.||||
  Fly   454 WSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQ-MKYKDERVKLMNEV 517

Human   362 LTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQ---SITVGVAPIVVVIASVVTFSVHM- 422
            |:.||.:|:|||..:|.:.|..||::|...|....|..   |.....||.:|   |:|||:.::
  Fly   518 LSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLV---SLVTFATYVL 579

Human   423 -TLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEV--HMIKNKPA 484
             :....|:..:....:.:|:.|...|.:.|.....::|..|:|:|.......||:  :.:.:..:
  Fly   580 TSEANQLSVEKVLVSIALFDLMKLPLTILPMLSVDIAETQVSVNRINKFLNSEELDPNSVLHDSS 644

Human   485 SPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHL 549
            .|| .:.::|...:|
  Fly   645 KPH-PMSIENGEFSW-------------------------------------------------- 658

Human   550 LLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTL 614
                          |..|         ||.:|::|:::|.||.:.|:|||||:|::.|.||:|..
  Fly   659 --------------GDEI---------TLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEK 700

Human   615 LEGSIAISGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIG 679
            |.|.:...|..|||.|||||.|||:|||||||:.||.:|||.|:::|.||.|:.||.:.||||||
  Fly   701 LAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIG 765

Human   680 ERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAI--RKHLKSKTVLFVTH 742
            |:|.||||||:||||||||:|||..:|:|||||||:|||||.|||...|  :..|..|:.:.|||
  Fly   766 EKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTH 830

Human   743 QLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYAT-IFNNLLLGETPPVEINSKK-------- 798
            .:.:|...|.:..:|.|.|:|.||.::|:...|.:|. |..:|..|.....|:|..|
  Fly   831 GVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTAD 895

Human   799 --ETSGSQKK-------------------------------------SQDKGPKTGSVKKEKAVK 824
              |..|:.:|                                     |.|......|:||::.|
  Fly   896 VPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKKQEV- 959

Human   825 PEEGQLVQLEEKGQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAF---STWWLSYWIKQ 886
              ||:|::.|:...|.|.::||..||::.|   .||.: |..:||....||   |..||:.|
  Fly   960 --EGKLIETEKSQTGGVEFAVYKHYIKSVG---IFLSV-ATLVLNFVFQAFQIGSNLWLTQW--- 1015

Human   887 GSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDEL 951
             :.:..|  .|:|.:.|         .|..:|........:|.....|:...|..:|:..:|:||
  Fly  1016 -ANDQNV--ANDTGLRD---------MYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNEL 1068

Human   952 FRRILR-SPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFL 1015
            ...|:| |..:|||.||.||:||.||.|||.||..||...:.|:..:.:|...:.:|:...|.||
  Fly  1069 LAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFL 1133

Human  1016 VAVGPLVILFSVLHIVSRVLI---RELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRY 1077
            ..:.|:..|:   :...|..:   |:|.||:::::||..||.:.::.|.:||.|||.|..|:...
  Fly  1134 AVIVPIAFLY---YFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEES 1195

Human  1078 QELLDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGL 1142
            ...:|.||...:....|.||||:||:::...:|....|..|| .||..|...||::|||:|:|..
  Fly  1196 DAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQT 1259

Human  1143 FQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSP-DWPQEGEVTFENAEMRYRENL 1206
            ..:.||::|:.|....|||||..|.:| ..|||..::.....| :|||||.|.|:|.::||||.|
  Fly  1260 LNWLVRMSSDIETNIVSVERIKEYGET-KQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGL 1323

Human  1207 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLS 1271
            .|||:.|||.|:..||:|||||||:|||||.:||||::|.:||.|.||||.|:.:||..|||:|:
  Fly  1324 DLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLT 1388

Human  1272 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1336
            ||||:||||||::|.|||||...|:|:||.|||.:|:|..:..|...|..|:.|.|:|.|||:||
  Fly  1389 IIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQ 1453

Human  1337 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1401
            |:|:||||||..|:|:|||||||:|.|||.|||:|||..|.:||:|||||||:|:|.||:::||.
  Fly  1454 LVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLD 1518

Human  1402 QGQVVEFDTPSVLLSNDSSRFYAM 1425
            :||::||.:|:.||.|..|.||:|
  Fly  1519 KGQIIEFASPTELLDNPKSAFYSM 1542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	492/1432 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		0/36 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		11/79 (14%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	496/1454 (34%)