Protein Alignment ABCC5 and CG7806

DIOPT Version :10

• Sequence 1: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Sequence 2: NP_609207.1
• Gene: CG7806 / 34140
• FlyBaseID: FBgn0032018
• Length: 1487
• Species: Drosophila melanogaster
• Alignment Length: 1372
• Identity: 419/1372 - (30%)
• Similarity: 673/1372 - (49%)
• Gaps: 159/1372 - (11%)

Human    99 HPVDNAGLFSCMTFSWLSSLARVAHKKGEL-SMEDVWSLSKHESSDVNCRRLERLWQEELNEVGP 162
            |..|.|.|.|...|.|:..|. :....|:| .:||::.|    ...:|..||    .|:|:....
  Fly   225 HAQDEANLGSRFLFHWVQPLI-LKGVAGKLRKIEDLFDL----PDALNITRL----SEKLHLALS 280

Human   163 DAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYSLLLVLGLLL 227
            .:.||.|.:.........|..:..:|..|:||:|| .::..||....|..:.:.|..|.:.|..|
  Fly   281 QSQSLWRALHRCFGVEFYLIGILRLIADLSGFAGP-LLLGGLLRQDHADPNQVYYYALGLFGSTL 344

Human   228 TEIVRS----WSLALTWALNYRTGVRLRGAILTMAFKKILKLKNIKEKSLGELINICSNDGQRMF 288
            ...|.:    |.:|:       ..:::|..::...::|.|:.:.:|| |..:|:|:.|.|..|:.
  Fly   345 LSAVCATHFDWRMAM-------VSMKMRVGVVNSIYRKALEARGLKE-SKPDLLNLMSTDTDRIV 401

Human   289 EAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFLGSAVF-ILFYPAMMFASRLTAYFRRKCVAA 350
            .:..........|  :...|.::|  :.|| ..||...:| .|..|...:.::....|....:.|
  Fly   402 NSCISFHFFWSIPFKLFTTLYLLY--LQLG-AAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTA 463

Human   351 TDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASV 415
            .|.|:....|.:...|.||:.||...|...::.:|:||.|.|.|..|..::.|.......|:..:
  Fly   464 KDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWATTPVLMCL 528

Human   416 VTFSVHMTLGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIK 480
            :||.|.:.:|..|.|:..:|.|.:...:...|...|:.:..|.||.|::.|.:.  ||:    :.
  Fly   529 LTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNAFPWVLNGLIEAWVSIKRVQQ--LMD----VP 587

Human   481 NKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQ 545
            |...|.:.     |..:.......:..::|...||                       .:||..:
  Fly   588 NLDYSSYY-----NPIMRGSGGSGAGDDAPLDAPK-----------------------ASVLQMK 624

Human   546 KGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILG 610
            ......||||:.||.....|              .|:::|:.|:||.|.|.||.||:|.:|||:.
  Fly   625 CASFCHDSDEQTSPTPFRMK--------------DINVDIKAGQLVCIEGPVGGGKSSFLSAIVA 675

Human   611 QMTLLEGSIAI---SGTFAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPS 672
            .:...:|.:.:   :..|.||.|..|:...|:||||::|.::||:.|.:||::|.|..||.|| .
  Fly   676 NLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQIL-G 739

Human   673 SDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTV 737
            .||..:||.|..||||||.|::||||:|.|:.:|:|||.||:|||||..||....|.:.||.||.
  Fly   740 GDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTR 804

Human   738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGE------TPPVEINS 796
            :.||..:|.....::::.:|:|.:           |..:|.|....|.|.|      .|.|...|
  Fly   805 IVVTRNIQLFFHANQILQVKDGQL-----------LPSEYMTQSIELSLDEDADDEQEPTVRRRS 858

Human   797 KKETSGSQKKSQDKGPKTGSVKKEKAVKPEEGQLVQLEE-KGQGSVPWSVYGVYIQAAGGPLAFL 860
            .:.::...|||.|.                    :.||| :..|.:..:|:..|.:|...||||.
  Fly   859 VELSNQYDKKSLDS--------------------LLLEELREYGHLSGNVFTCYWKAVTSPLAFT 903

Human   861 VIMALFMLNVGSTAFSTWWLSYWIKQGS-----GNTTV-------TRGNETSVSDSMKDNPHMQY 913
            |::::.::.: :...|..||:||:.:.:     .:|::       |.||||....:.|      :
  Fly   904 VLLSVVLMQL-TRNLSDAWLAYWVTETTLDPHKNDTSLDHILMRPTVGNETESGHTTK------F 961

Human   914 YASIY-ALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSK 977
            |.||: |::::..|:..| |..:|....::|:..:|::|.::::.:...|||.|..||||||||.
  Fly   962 YLSIFTAIAVSNSLVTLA-RAFLFAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSS 1025

Human   978 DMDEVDVRLPFQAEMFIQNVILV-------FFCVGMIAGVFPWFLVAVGPLVILFSVLHIVSRVL 1035
            |.:.||..||     ||.|::|.       ..||.:.|  .||..:.:.|:|.::..|....|..
  Fly  1026 DTNTVDDSLP-----FILNILLAQLAGLVGALCVSLYA--MPWLGLVIIPMVPIYLSLQQRYRHA 1083

Human  1036 IRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPFFLFTCAMRWLAV 1100
            .|::|||.:...||..:|.|.::|||.||.:......|...:|..|:::.......:.|.:|||:
  Fly  1084 SRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEESIKAQLTQSAAQQWLAL 1148

Human  1101 RLDLISIALITTTGLMIVLMHGQIP-PAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERIN 1164
            ||.|:...|:...||:..:...... |...||.||||:.:||.....:...:|||....:||||:
  Fly  1149 RLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERID 1213

Human  1165 HYIKTLSLEAPARIKNKAPSP-DWPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGR 1228
            .|   |.||........|..| .||.:|.::|...::.|||:|...|:.::|..:..|:||||||
  Fly  1214 QY---LQLEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAPALRGITFQTEAFERIGIVGR 1275

Human  1229 TGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQ 1293
            ||:||:|:..||.|:..|:.|.|::|.|.:..:.|:.||.::.:|.|||.||.||||.||||.:.
  Fly  1276 TGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHG 1340

Human  1294 YTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATA 1358
            :.:.:||.|::.:.....:.|....|:.:|...|:|.|.|:|||||:|||||::.|::.:||.|:
  Fly  1341 FYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTS 1405

Human  1359 AMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFY 1423
            .:|.|:||.||:.:|.||..||:|.|||||..:...|||:||..|::.|...|..|.|:.|:.||
  Fly  1406 NLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNPQSLASDSSTIFY 1470

Human  1424 AMFAAAE 1430
            .|..|.:
  Fly  1471 GMLLAQD 1477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	416/1364 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		3/36 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		5/32 (16%)
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	417/1365 (31%)