Protein Alignment ABCC5 and CG31793

DIOPT Version :10

• Sequence 1: NP_005679.2
• Gene: ABCC5 / 10057
• HGNCID: 56
• Length: 1437
• Species: Homo sapiens
• Sequence 2: NP_609930.4
• Gene: CG31793 / 326161
• FlyBaseID: FBgn0051793
• Length: 1307
• Species: Drosophila melanogaster
• Alignment Length: 1390
• Identity: 460/1390 - (33%)
• Similarity: 745/1390 - (53%)
• Gaps: 178/1390 - (12%)

Human    99 HPVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVW-SLSKHESSDVNCRRLERLWQEEL----- 157
            :|.::||:.|.:.|.:...:. ...:|..|...|:: :|::||::.:.....:. |::|:
  Fly     9 NPRESAGILSSLMFCFALPIL-FKGRKQTLQPTDLYKTLNEHEAASLGDEFFQG-WEDEVARCRR 71

Human   158 -NEVGPDAASLRRVVWIFCRTRLILSIVCLMITQ----------LAGFSGPAFMVKHLLEYTQAT 211
             .:.|...:.||.:..:| ..|||:|.:.:...:          |||      ::....|:....
  Fly    72 KGDSGRKPSVLRVIGRVF-GWRLIMSGITIAALELGTRATVPLLLAG------LISEFSEHGNGH 129

Human   212 ESNLQ-YSLLLVLGLLLTEIVRSWSLALTWALNYRTG-----VRLRGAILTMAFKKILKLK--NI 268
            ..|.| |::||:..:|.       |:.||..  |..|     :::|.|:.:..::|.|:|.  ::
  Fly   130 SYNAQIYAVLLIACILA-------SVLLTHP--YMMGMMHLAMKMRVAVSSAIYRKALRLSRTSL 185

Human   269 KEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFYPAM 333
            ...:.|:::|:.|||..|..........|..||:..::...:....:|...|.|.::.:|:.|..
  Fly   186 GGTTTGQVVNLLSNDLNRFDRCLIHFHFLWLGPLELLIASYFLYEQIGMASFYGISILVLYLPLQ 250

Human   334 MFASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEKAGYF 398
            .:.||:|:..|.:....||:||:.|||:::.|:.||||.|.:.|.:.:.::|..|...:.:....
  Fly   251 TYLSRVTSKLRLQTALRTDQRVRMMNEIISGIQVIKMYTWERPFGKLIGQMRRSEMSSIRQMNLL 315

Human   399 QSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFAL-KVTPFSVKSLSEASV 462
            :.|.:.....:..||..|:....:..|.:|||.:||.|...:|.:...: |..|..:...:|..|
  Fly   316 RGILLSFEITLGRIAIFVSLLGFVLGGGELTAERAFCVTAFYNILRRTVSKFFPSGMSQFAELLV 380

Human   463 AVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKK 527
            ::.|..:..:.||.::|                    |.|.             ::|::
  Fly   381 SMRRITNFMMREEANVI--------------------DMSE-------------RRDEK------ 406

Human   528 EKVRQLQRTEHQAVLAEQKGHLLLDSDERPSP---EEEEGKHIHLGHLRLQ-------RTLHSID 582
                           ||::.|||.:.::|..|   .:|....:.:..||.:       ..|::::
  Fly   407 ---------------AEEEQHLLKEVEKRSYPVGIGKEPDTLVEIKALRARWGQEQHDLVLNNVN 456

Human   583 LEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQQAWILNATLRDNILFGK 647
            :.::.|:||.:.|.|||||:|||.||||::....||:.:||.::|.:|:.|:.||::|||||||.
  Fly   457 MSLRRGQLVAVIGPVGSGKSSLIQAILGELPPESGSVQVSGKYSYASQEPWLFNASVRDNILFGL 521

Human   648 EYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDPL 712
            ..|::||.:||..|.|..||.:| ..|.|.:|||||:||||||.||.||||:|....:|:|||||
  Fly   522 PMDKQRYRTVLKRCALERDLELL-HGDGTIVGERGASLSGGQRARICLARAVYRRADVYLLDDPL 585

Human   713 SALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
            ||:|.|||.|:|:..:|..|..:.|:.||||||:|.|.|.::.|.:|.::..||:||::....|:
  Fly   586 SAVDTHVGRHLFDECMRGFLGKQLVILVTHQLQFLEDADLIVIMDKGHVSACGTYEEMLKSGQDF 650

Human   778 ATIF----NNLLLGETPPVEINSKKETSGSQKKSQDKGPKT--GSVKKEKAVKPEEGQLVQLEEK 836
            |.:.    .|...|:......|..:::|....||.:....:  ..|:||   ||:...:...|.:
  Fly   651 AQLLVESTQNSGGGDEIITSPNLSRQSSALSTKSSNGSSSSLESMVEKE---KPKPSAVSSQESR 712

Human   837 GQGSVPWSVYGVYIQAAGGPLAFLVIMALFMLNVGSTAFST---WWLSYWIKQGSGNTTVTRGNE 898
            ..|.:..|:|..|..|..|.|.|:|   |.||.:|:...::   ::||||:|..:.::|:
  Fly   713 SGGQIGLSMYKKYFGAGCGVLVFVV---LIMLCIGTQILASGGDYFLSYWVKNTASSSTL----- 769

Human   899 TSVSDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFF 963
                       .:.|:.:|    ...::|...:|.::|...|:.:|:.||:.:|:.:.|:.:.||
  Fly   770 -----------DIYYFTAI----NVGLVICALLRTLLFFNITMHSSTELHNTMFQGLSRTALYFF 819

Human   964 DTTPTGRILNRFSKDMDEVDVRLP------FQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPLV 1022
            .|.|:|||||||:.|:.:||..:|      .|..:.:..:|.| .||     ..||:|:....::
  Fly   820 HTNPSGRILNRFANDLGQVDEVMPAVMLDCIQIFLTLTGIICV-LCV-----TNPWYLINTFAMM 878

Human  1023 ILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAP 1087
            :.|...........|::|||:.:.:||..||.::::.||.||.|....|..:.:|....|.:.:.
  Fly   879 LAFYYWRDFYLKTSRDVKRLEAVARSPMYSHFSATLVGLPTIRAMGAQQTLIGQYDNYQDLHSSG 943

Human  1088 FFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQI-PPAY----AGLAISYAVQLTGLFQFTV 1147
            ::.|....|.....|||..:|.:.:     |::|... ||.:    .||||:.|:.:||:.|:.:
  Fly   944 YYTFVSTSRAFGYYLDLFCVAYVIS-----VILHNFFNPPLHNAGQIGLAITQALGMTGMVQWGM 1003

Human  1148 RLASETEARFTSVERINHYIKTLSLE----APARIKNKAPSPDWPQEGEVTFENAEMRYR--ENL 1206
            |.::|.|...|||||:..| |.|..|    :||   .|.|...||:||::..::..:||.  .|.
  Fly  1004 RQSAELENAMTSVERVLEY-KDLDPEGDFNSPA---EKQPPKSWPKEGKLVTKDLSLRYEPDTNS 1064

Human  1207 PLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLS 1271
            |.|||.:||||:|.||:|||||||:|||||..||||| ..:.|.|.||.:..:||||.|||||:|
  Fly  1065 PCVLKGLSFTIQPMEKVGIVGRTGAGKSSLINALFRL-SYNDGAILIDSLDTNDIGLHDLRSKIS 1128

Human  1272 IIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQ 1336
            ||||||||||||:|.|||||.||.:|::|.|||..|:||.|::||..|:|.:.|.|.|||||:||
  Fly  1129 IIPQEPVLFSGTMRYNLDPFEQYPDDKLWKALEDVHLKEEISELPSGLQSIISEGGTNFSVGQRQ 1193

Human  1337 LLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLA 1401
            |:|:|||:||..:||::|||||.:|.:||.|||.|||..|.|||:|||||||:|::.||:::|:.
  Fly  1194 LVCLARAILRENRILVMDEATANVDPQTDALIQATIRNKFKDCTVLTIAHRLNTIMDSDKVLVMD 1258

Human  1402 QGQVVEFDTPSVLLSNDSSR-FYAM 1425
            .|.||||.:|..||:...:: |:.|
  Fly  1259 AGHVVEFGSPYELLTASKAKVFHGM 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ABCC5	NP_005679.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..41
		PLN03130	100..1425	CDD:215595	459/1387 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..538		2/36 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	794..827		9/34 (26%)
CG31793	NP_609930.4	PLN03130	10..1305	CDD:215595	460/1389 (33%)