DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LOC100536511 and H10E21.5

DIOPT Version :9

Sequence 1:	XP_021329973.1	Gene:	LOC100536511 / 100536511	-ID:	-	Length:	400	Species:	Danio rerio
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	195	Identity:	57/195 - (29%)
Similarity:	94/195 - (48%)	Gaps:	17/195 - (8%)

- Green bases have known domain annotations that are detailed below.

Zfish   196 LSFTFIGITAVTMFYFAFLFMKRMYINRQLRRQQMEIKRETEKAIGKLEVRTLRTN-DPEVDSDD 259
            :|.:||.:..:::.:..|.:::|........|.|..:.....||:.::...|:... ..|:.||
Worm   163 VSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPGMTQELQSD- 226

Zfish   260 TGCVVCTDSYQRGEQVTVLPCRHLYHKKCIEPWLLEHPTCPMCKYNILK-----SSIEEDSYDQP 319
              |.||.|.||..:.:.:|||:|:|||.||:||||||.||||||.:|||     :.|..| ...|
Worm   227 --CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGYWNDIRND-IQMP 288

Zfish   320 SPSSSSSSSSSSNDTFCLATITSADQRSTLQSNIQTEETAGGHTSDTVNCNLDIHTQHIYDNPGF 384
                  ::|....|.|.:.......:.....:::.:.| |...|||:...:.|....|..::.|:
Worm   289 ------TNSRGIADDFTIRLELGEQEHQAPSADVISPE-ANSDTSDSQGFSFDNSEHHHSESFGY 346

Zfish 385 384
Worm 347 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LOC100536511	XP_021329973.1	PA_GRAIL_like	47..179	CDD:239037
		zf-rbx1	<188..303	CDD:331150	38/107 (36%)
		RING_Ubox	262..308	CDD:327409	28/45 (62%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	51/172 (30%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	29/49 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010