DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C8orf44-SGK3 and S6k

DIOPT Version :9

Sequence 1:	NP_001191102.1	Gene:	C8orf44-SGK3 / 100533105	HGNCID:	48354	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	160/371 - (43%)
Similarity:	230/371 - (61%)	Gaps:	20/371 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   132 EDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDG----KFYAVKV 192
            :|....:.:....:|:|   .|.....|.||:..||:|||.:|||... ||..|    |::|:||
  Fly    50 QDTEGQETIQLCEENVN---PGKIKLGPKDFELKKVLGKGGYGKVFQV-RKTAGRDANKYFAMKV 110

Human   193 LQK-KIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRER 256
            |:| .||.|:|:..|..||||: |:.|||||:|.|.|:|||..|||.:|::::|||||.||:||.
  Fly   111 LKKASIVTNQKDTAHTRAERNI-LEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREG 174

Human   257 SFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTF 321
            .|.|....||.:||..|||:||.:.|:||||||||||||:.|||.|||||||||.|.....|.||
  Fly   175 IFLEDTTCFYLSEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTF 239

Human   322 CGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSL 386
            |||.||:|||::.:..:...||||.|||::::||.|:|||...:..:..:.||...|:|...::.
  Fly   240 CGTIEYMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTP 304

Human   387 TAWSILEELLEKDRQNRLGA-KEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFD 450
            .|..::..|:::....|||: .||...:|.||||:.::|.|::.:::.||..|.:...||:..||
  Fly   305 EARDLVRRLMKRQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFD 369

Human   451 TAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPS--EDL 494
            |.||.: :|..   |.|.:.::.|   |:..|.||:|..||  ||:
  Fly   370 TRFTRQ-IPVD---SPDDTTLSES---ANLIFQGFTYVAPSILEDM 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C8orf44-SGK3	NP_001191102.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PX_CISK	12..120	CDD:132780
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..156		4/23 (17%)
		STKc_SGK3	165..490	CDD:270755	149/330 (45%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		5/10 (50%)
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	148/329 (45%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	149/329 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0598
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710