DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EPPIN-WFDC6 and tfpi2

DIOPT Version :9

Sequence 1:	NP_001185915.1	Gene:	EPPIN-WFDC6 / 100526773	HGNCID:	38825	Length:	179	Species:	Homo sapiens
Sequence 2:	NP_001035185.1	Gene:	tfpi2 / 560339	ZFINID:	ZDB-GENE-060503-38	Length:	233	Species:	Danio rerio

Alignment Length:	192	Identity:	57/192 - (29%)
Similarity:	80/192 - (41%)	Gaps:	43/192 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     6 LLSLLVLFVLLANVQGPGLTDWLFPRRCPKIREECEFQ-ERDVCTKD----------RQC----- 54
            ||..|:||:.:.. ...|||  |.|      :|.|..| |...|..|          :||
Zfish     5 LLGALLLFISVLE-SAVGLT--LQP------KEVCLLQIEEGTCNDDIQRFYYNTISQQCEEFSY 60

Human    55 ------QDNKKCCVFSCGKKCLDLKQ--DVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQ 111
                  |:|.:..| .|.|.|..:.:  .:|...|:.|||...|..::::.....|..|.|||||
Zfish    61 SGCGGNQNNFRSFV-ECQKTCFRIPKIPQICRFQKKEGPCRGLFSRYFFNMTSMQCEPFTYGGCQ 124

Human   112 GNNNNFQSKANCLNTCKNKQPCPKIKVECEVEEIDQCTKPRDCPENMKCCPF-SRGKKCLDF 172
            ||.|||::...|:..||   |...|.|.|    :|...|.| |..::....: |..|.|.:|
Zfish   125 GNENNFRNPEECIEYCK---PPKTIPVIC----LDNLDKGR-CSASIPRYYYNSATKTCEEF 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EPPIN-WFDC6	NP_001185915.1	WAP	32..71	CDD:278522	14/60 (23%)
EPPIN-WFDC6	NP_001185915.1	Kunitz_BPTI	76..128	CDD:278443	19/51 (37%)
tfpi2	NP_001035185.1	KU	28..80	CDD:197529	13/52 (25%)
		Kunitz_BPTI	89..141	CDD:278443	19/51 (37%)
		Kunitz_BPTI	149..201	CDD:278443	9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000145
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810