DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM14-RBM4 and lark

DIOPT Version :9

Sequence 1:	NP_001185774.1	Gene:	RBM14-RBM4 / 100526737	HGNCID:	38840	Length:	339	Species:	Homo sapiens
Sequence 2:	NP_523957.1	Gene:	lark / 38811	FlyBaseID:	FBgn0011640	Length:	352	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	110/372 - (29%)
Similarity:	150/372 - (40%)	Gaps:	114/372 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     2 KIFVGNVDGADTTPEELAALFAPYGTVMSCAVMKQFAFVHMRENAGALRAIEALHGHELRPGRAL 66
            |:|:||:| ..|...||.|||..||||:.|.|:|.:.||||........||:.|:|:.|.. .|:
  Fly     8 KLFIGNLD-EKTQATELRALFEKYGTVVECDVVKNYGFVHMETEQQGRDAIQNLNGYTLNE-FAI 70

Human    67 VVEMSRPR-----PLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVK-------------- 112
            .||.::.|     |  |.||||||::....:.|:|.||::.|.|:|||:|:
  Fly    71 KVEAAKSRRAPNTP--TTKIFVGNLTDKTRAPEVRELFQKYGTVVECDIVRNYGFVHLDCVGDVQ 133

Human   113 ------------GKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQY 165
                        |:.:.||:||||:|..|||||...|||||:.||||||||           ..|
  Fly   134 DAIKELNGRVVDGQPLKVQVSTSRVRPKPGMGDPEQCYRCGRSGHWSKECP-----------RLY 187

Human   166 NEQYGAVRTPYTMSYGDSLYYNNAYGALDAY--------YKRCRAARSYEAVAAAAASVYNYAEQ 222
            ....|....|..:|.|.  |.:..||. |.|        :.|.|....:..        |:|.::
  Fly   188 GSAGGGREPPSPLSAGG--YRDRMYGR-DPYPPPPPPPPFLRDRIMDGFRD--------YDYYDR 241

Human   223 TLSQLPQVQNTAMASHLTSTSLDPYDRHLLPTSGAAATAAAAAAAAAAVTAASTSYYGRDRSP-- 285
            ....                |.|.|:|..                       .||.. ||..|
  Fly   242 RFED----------------SRDLYERRY-----------------------QTSRM-RDFPPPP 266

Human   286 -LRRATAPVPTVGEG------YGYGHESELSQASAAARNSLYDMARY 325
             .||...|:|....|      ...|:::..|:.|.....|...|:||
  Fly   267 ISRREPMPLPPTLSGSLRSCSVSRGYDTMFSRRSPPPPRSSNGMSRY 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM14-RBM4	NP_001185774.1	RRM1_CoAA	1..71	CDD:241052	30/68 (44%)
		RRM_SF	79..>113	CDD:302621	16/59 (27%)
		ZnF_C2HC	136..151	CDD:197667	11/14 (79%)
lark	NP_523957.1	RRM1_2_CoAA_like	8..73	CDD:409779	28/66 (42%)
		RRM1_2_CoAA_like	87..152	CDD:409779	17/64 (27%)
		hnRNP-R-Q	<88..>258	CDD:273732	60/230 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0109
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910