DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RBM14-RBM4 and pabp

DIOPT Version :9

Sequence 1:	NP_001185774.1	Gene:	RBM14-RBM4 / 100526737	HGNCID:	38840	Length:	339	Species:	Homo sapiens
Sequence 2:	NP_593377.1	Gene:	pabp / 2541505	PomBaseID:	SPAC57A7.04c	Length:	653	Species:	Schizosaccharomyces pombe

Alignment Length:	364	Identity:	70/364 - (19%)
Similarity:	121/364 - (33%)	Gaps:	81/364 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     3 IFVGNVDGADTTPEELAALFAPYGTVMSCAV-------MKQFAFVHMRENAGALRAIEALHG--- 57
            :|:.|:|.| ...:.|...|:.:|.::||.|       .|.:.|||......|..|||.::|
pombe   170 VFIKNLDPA-IDNKALHDTFSAFGKILSCKVAVDELGNAKGYGFVHFDSVESANAAIEHVNGMLL 233

Human    58 ---------HELRPGRALVVEMSRPRPLNTWKIFVGNVSAACTSQELRSLFERRGRVIECDVVKG 113
                     |..|..|...||..:   .|...:::.|:....|.||...||.:.|.:....:||.
pombe   234 NDKKVYVGHHVSRRERQSKVEALK---ANFTNVYIKNLDTEITEQEFSDLFGQFGEITSLSLVKD 295

Human   114 KRMHVQLSTSRLRTAPGMGDQS-GCYRCGKEG--------HWSKECPIDRSGRVADLTEQYNEQY 169
            :....:          |.|..: ..:.|.::.        :..|:..:.|:.:..:..|:..::|
pombe   296 QNDKPR----------GFGFVNYANHECAQKAVDELNDKEYKGKKLYVGRAQKKHEREEELRKRY 350

Human   170 GAVRTPYTMSY-GDSLYYNNAYGALDAYYKRCRAARS-------------------------YEA 208
            ..::......| |.:|:..|....:|.  :|.:|..|                         |..
pombe   351 EQMKLEKMNKYQGVNLFIKNLQDEVDD--ERLKAEFSAFGTITSAKIMTDEQGKSKGFGFVCYTT 413

Human   209 VAAAAASVYNYAEQTLSQLPQVQNTAMASHLTSTSLDPYDRHLLPTSGAAATAAAAAAAAAAVTA 273
            ...|..:|....::.|:..|.....|....:..:.|:...:...........||||...|....|
pombe   414 PEEANKAVTEMNQRMLAGKPLYVALAQRKEVRRSQLEAQIQARNQFRLQQQVAAAAGIPAVQYGA 478

Human   274 ASTSYYGRDRSPLRRATAPVPTVGEGYGY----GHESEL 308
            .....||       ....|:|....|.|.    ||...:
pombe   479 TGPLIYG-------PGGYPIPAAVNGRGMPMVPGHNGPM 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RBM14-RBM4	NP_001185774.1	RRM1_CoAA	1..71	CDD:241052	24/86 (28%)
		RRM_SF	79..>113	CDD:302621	8/33 (24%)
		ZnF_C2HC	136..151	CDD:197667	2/22 (9%)
pabp	NP_593377.1	PABP-1234	80..642	CDD:130689	70/364 (19%)
		RRM1_I_PABPs	81..160	CDD:240824
		RRM2_I_PABPs	166..242	CDD:240825	19/72 (26%)
		RRM3_I_PABPs	260..339	CDD:240826	14/88 (16%)
		RRM4_I_PABPs	363..441	CDD:240827	13/79 (16%)
		PolyA	581..644	CDD:197769
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910