DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment myo1d and zip

DIOPT Version :9

Sequence 1:	XP_002935562.1	Gene:	myo1d / 100497691	XenbaseID:	XB-GENE-5877220	Length:	1007	Species:	Xenopus tropicalis
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	954	Identity:	311/954 - (32%)
Similarity:	466/954 - (48%)	Gaps:	187/954 - (19%)

- Green bases have known domain annotations that are detailed below.

Frog     3 EQEGLQFGKADFVLMDSV---TLPEF-----------------MENLKLRFEKGRIYTFIGEVVV 47
            |.|..:.||...:|.|.:   ..|:|                 :.|:|.|:..|.|||:.|...|
  Fly   105 EVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCV 169

Frog    48 SVNPYKNLPIYGRDTIEQYKGRELYERPPHLFSIADAAYKAMKRRCKDTCIVISGESGAGKTEAS 112
            .|||||.||||....:|:|||.:.:|.|||:|:|.|:||:.|....:|..|:.:|||||||||.:
  Fly   170 VVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENT 234

Frog   113 KYIMQYIA-----------AITNPS---------------------------------------- 126
            |.::|::|           |:.:|:
  Fly   235 KKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSN 299

Frog   127 -QRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHISNYLLEKSR 190
             |..|:|:   .||::|.:|||||||||.:|||||||||::.||||..|...|.:|..|||||||
  Fly   300 CQEGELEQ---QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSR 361

Frog   191 VIVQQLGERNFHSFYQMILGA-PEQTLRSLHLQKDISLYAYTRSLAQLKSSNNDTGDFKDVAEAM 254
            .|.|...||.||.|||::.|| |||  |...:..|:..||:..:.:......:|..:|:...::|
  Fly   362 AIRQAKDERTFHIFYQLLAGATPEQ--REKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSM 424

Frog   255 KVIGFKPEEIQTVYKILAAILHLGNLKF--VLDGDTTLIENGKVISVVADLLGTRSEQVEKALLF 317
            .::|...|:..::::|::|:|..|::||  ..:.|...:.:..|...:|.|||.....:.:|.|.
  Fly   425 NIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLT 489

Frog   318 RTVATGRDVIDKQHTEKEANYGRDAFAKAIYERLFCWIVNRINDVID-VKQQDAALHGKNTVIGV 381
            ..:..|||.:.|..|:::..:..:|.|||.|||:|.|:|||||..:| .|:|.|:.      ||:
  Fly   490 PRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASF------IGI 548

Frog   382 LDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLTQEQAEYQREGIPWKHIDY-FDNQIIVDLV 445
            ||:.|||||:.|||||.||||.||||||||...:...||.|||||||.||.||: .|.|..:||:
  Fly   549 LDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLI 613

Frog   446 EQQHRGIIALLDDACMNVGKVTDNMFLEALDKQLGKHAHYSSRKVCATDKALEYNRDFRIRHYAG 510
            ::. .||:||||:.|. ..|.||..|::.|     ..||....|...||  .....||.|.||||
  Fly   614 DKP-GGIMALLDEECW-FPKATDKTFVDKL-----VSAHSMHPKFMKTD--FRGVADFAIVHYAG 669

Frog   511 DVVYSVVGFIDKNKDTLFQDFKRLMFNSSNAVLKAMWPEGKL------SITEV-----TKRPL-- 562
            .|.||...::.||.|.|.::...|:..|.:..:..:|.:.::      ::|:.     |::.:
  Fly   670 RVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFR 734

Frog   563 TAATLFKNSMIALVDNLASKEPYYVRCIKPNEKK------SPALFDEVRCKHQVEYLGLLENVRV 621
            |.:.|:|..:..|:|.|.:..|.:||||.||.:|      :|.:.|::||.      |:||.:|:
  Fly   735 TVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN------GVLEGIRI 793

Frog   622 RRAGFAYRQVYEKFLHRYKLISSLTWPNHSLPSDRIAVERFMVDCGLNHDA-AYGKTKIFIRTPR 685
            .|.||..|..:::|..||:|::....|...:...: |.|:.:....|:.:. ..|::|||.|. .
  Fly   794 CRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKK-ACEKMIQALELDSNLYRVGQSKIFFRA-G 856

Frog   686 TLFFLEERRSEMLIRIILFLQKLWRGTLARRRCKRIRAGLTILRYYRRYKVKSYLREVMHRFNGV 750
            .|..|||.|...:..:|:..|...||.||||..::....|..:|..:| ...:||:
  Fly   857 VLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQR-NCAAYLK--------- 911

Frog   751 KNSRDYGKHVKWPTPPKVLRRFQEALQHIYNRWRGYQIIRSLPPAEIPKVRAKVAAFEN-LKGHR 814
                              ||.:|        .||.|..::  |..|:.|...|:...|: ||..|
  Fly   912 ------------------LRNWQ--------WWRLYTKVK--PLLEVTKQEEKLVQKEDELKQVR 948

Frog   815 VDMGLQRCWEGSYLALNQENGRDSDLFVSRSSELQRKDKFMQAL 858
            ..:                     |.....:.|.:|  |:.|||
  Fly   949 EKL---------------------DTLAKNTQEYER--KYQQAL 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo1d	XP_002935562.1	MYSc_Myo1	24..682	CDD:276829	264/751 (35%)
myo1d	XP_002935562.1	Myosin_TH1	803..1004	CDD:368706	12/57 (21%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	4/11 (36%)
		Myosin_head	133..854	CDD:278492	263/747 (35%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	263/735 (36%)
		Myosin_tail_1	931..2011	CDD:279860	13/62 (21%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000