DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment myo1d and Mhc

DIOPT Version :9

Sequence 1:	XP_002935562.1	Gene:	myo1d / 100497691	XenbaseID:	XB-GENE-5877220	Length:	1007	Species:	Xenopus tropicalis
Sequence 2:	NP_001162991.1	Gene:	Mhc / 35007	FlyBaseID:	FBgn0264695	Length:	1962	Species:	Drosophila melanogaster

Alignment Length:	944	Identity:	300/944 - (31%)
Similarity:	461/944 - (48%)	Gaps:	138/944 - (14%)

- Green bases have known domain annotations that are detailed below.

Frog    13 DFVLMDSVTLPEFMENLKLRFEKGRIYTFIGEVVVSVNPYKNLPIYGRDTIEQYKGRELYERPPH 77
            |...|..:..|..:.||:.|:....|||:.|...|::||||..|:|.....:.|:|:...|.|||
  Fly    90 DMADMTVLNTPCVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPH 154

Frog    78 LFSIADAAYKAMKRRCKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNML---- 138
            :|:|:|.||..|.....:..::|:|||||||||.:|.::.|.|.:....:..|..:.|..|
  Fly   155 IFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGSLEDQV 219

Frog   139 LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHISNYLLEKSRVIVQQLGERNFHS 203
            :::|.||||||||||.||||||||||::.|:|...|...|..|..|||||:|||.||..||::|.
  Fly   220 VQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHI 284

Frog   204 FYQMILGAPEQTLRSLHLQKDI-----SLYAYTRSLAQLK---SSNNDTGDFKDVAEAMKVIGFK 260
            |||::.|       |:...|||     ::|.| ..::|.|   :|.:|..:|....:|..::||.
  Fly   285 FYQIMSG-------SVPGVKDICLLTDNIYDY-HIVSQGKVTVASIDDAEEFSLTDQAFDILGFT 341

Frog   261 PEEIQTVYKILAAILHLGNLKF---------VLDGDTTLIENGKVISVVADLLGTRSEQVEKALL 316
            .:|.:.||:|.||::|:|.:||         ..||:.   |.|:    |:.|.|..:.::.|.||
  Fly   342 KQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEE---EGGR----VSKLFGCDTAELYKNLL 399

Frog   317 FRTVATGRDVIDKQHTEKEANYGRDAFAKAIYERLFCWIVNRINDVIDVKQQDAALHGKNTVIGV 381
            ...:..|.:.:.:....::......|..|.:::|||.|:|.:.|:.:|.:|:      :...|||
  Fly   400 KPRIKVGNEFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQK------RQHFIGV 458

Frog   382 LDIYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLTQEQAEYQREGIPWKHIDY-FDNQIIVDLV 445
            |||.|||||:.|.|||.|||:.||||||.|...:...||.||:||||.|..||: .|....:||:
  Fly   459 LDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLI 523

Frog   446 EQQHRGIIALLDDACMNVGKVTDNMFLEAL-DKQLGKHAHYSSRKVCATDKALEYNRDFRIRHYA 509
            |:. .||:::|::..| ..|.||..|.|.| :..|||.|.:...|   ..|..:....|.|.|||
  Fly   524 EKP-MGILSILEEESM-FPKATDQTFSEKLTNTHLGKSAPFQKPK---PPKPGQQAAHFAIAHYA 583

Frog   510 GDVVYSVVGFIDKNK----DTLFQDFKRLMFNSSNAVLKAMWPE--GKLSITEVTKRP------- 561
            |.|.|::.|:::|||    ||:...||:    |.|.:|..::.:  |:....|..|..
  Fly   584 GCVSYNITGWLEKNKDPLNDTVVDQFKK----SQNKLLIEIFADHAGQSGGGEQAKGGRGKKGGG 644

Frog   562 -LTAATLFKNSMIALVDNLASKEPYYVRCIKPNEKKSPALFDEVRCKHQVEYLGLLENVRVRRAG 625
             .|.::.:|..:.:|:..|.|.:|::||||.|||.|.|.:.|.....||:...|:||.:|:.|.|
  Fly   645 FATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKG 709

Frog   626 FAYRQVYEKFLHRYKLISSLTWPN--HSLPSDRIAVERFMVDCGLNHDA-AYGKTKIFIRTPRTL 687
            |..|.:|..|..|||::.    |.  ..:..|:.|.|..:....|..|. ..|.||:|.|. ..|
  Fly   710 FPNRMMYPDFKMRYKIMC----PKLLQGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRA-GVL 769

Frog   688 FFLEERRSEMLIRIILFLQKLWRGTLARRRCKRIRAGLTILRYYRRYKVKSYLREVMHRFNGVKN 752
            ..:||.|.|.|.:|:.::|...||.|:|:..|:::.....|:..:|                  |
  Fly   770 GQMEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQR------------------N 816

Frog   753 SRDYGKHVKWP--------TPPKVLRRFQEALQHIYNRWRGYQIIRSLPPAEIPKVR-------- 801
            .|.|.:...||        .|...:.|.::.:..:..:.:..:   .|..||: |||
  Fly   817 LRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARLEEKAKKAE---ELHAAEV-KVRKELEALNA 877

Frog   802 ----AKVAAFENLKGHRVDMGLQRCWEGSYLALNQENGRDSDL----------FVSRSSELQRKD 852
                .|.|..::|.|.:  ..||...|.:.....|:|..::.|          ..:|:...|:|.
  Fly   878 KLLAEKTALLDSLSGEK--GALQDYQERNAKLTAQKNDLENQLRDIQERLTQEEDARNQLFQQKK 940

Frog   853 KFMQAL---------FSCHVRKVNRFNKVEDRAI 877
            |..|.:         ...:|:|..:....:|..|
  Fly   941 KADQEISGLKKDIEDLELNVQKAEQDKATKDHQI 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myo1d	XP_002935562.1	MYSc_Myo1	24..682	CDD:276829	249/697 (36%)
myo1d	XP_002935562.1	Myosin_TH1	803..1004	CDD:368706	19/94 (20%)
Mhc	NP_001162991.1	Myosin_N	36..73	CDD:280832
		MYSc	81..777	CDD:214580	256/721 (36%)
		MYSc_Myh1_insects_crustaceans	100..765	CDD:276874	250/698 (36%)
		Myosin_tail_1	842..1897	CDD:279860	26/139 (19%)
		V_Alix_like	1557..1877	CDD:187408
		ATP-synt_B	<1671..1771	CDD:304375
		TMPIT	1739..>1825	CDD:285135
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000