DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lck and Src42A

DIOPT Version :9

Sequence 1:	XP_012812855.2	Gene:	lck / 100497656	XenbaseID:	XB-GENE-6054021	Length:	503	Species:	Xenopus tropicalis
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	223/393 - (56%)
Similarity:	292/393 - (74%)	Gaps:	13/393 - (3%)

- Green bases have known domain annotations that are detailed below.

Frog   116 IESEMWFFRDLGRKDAERQLLAPGNQQGSFLVRESETTKGSYSLSVRDLDQNQGEVVKHYKIRNL 180
            :..:.|:||.:.|.:||::||.|.|:.|:||:|:||:....|||||||     |:.||||:||.|
  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSVRD-----GDTVKHYRIRQL 1264

Frog   181 DNGGFYISPRKTFQTLQELVQHYRRSSDGLCTLLKEPC-QTQRPQKPWWA----DEWEIPRNKLQ 240
            |.|||:|:.|.||:||||||:||.:.|||||..|.:|| |.::|.....:    |:|||.|..|:
  Fly  1265 DEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEKPVTEGLSHRTRDQWEIDRTSLK 1329

Frog   241 LVKKLGAGQFGEVWMGYYNGHTKVAIKSLKPGTMSPEAFLAEANLMKQLQHPRLVRLNAVVT-QE 304
            .|:|||:||||:||.|.:|..|.||||:||.|||.|:.|||||.:||:|:|.:|::|.||.| :|
  Fly  1330 FVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEE 1394

Frog   305 PIYIVTEYMEKGCLVDYLK--TSEGLKLTIYKLIDMSAQVAEGMAFLEHKNYIHRDLRAANILVS 367
            ||||:||.|:.|.|::||:  ..:|..|.:..||||:||:|.|||:||.:|||||||.|.|:||.
  Fly  1395 PIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVG 1459

Frog   368 ESLCCKIADFGLARVIVDNEYTAKEGAKFPIKWTAPEAINYGTFTIKSDVWSFGVLLTEIVTYGR 432
            :....|||||||||:|.::||.|:.||:||||||||||.||..|:|||||||||:||||:|||||
  Fly  1460 DGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGR 1524

Frog   433 IPYPGMTNPEVIENLERGYRMPQPDNCPMELYELMLRCWKEEPEERPTFEFLRSLLEDFFTATEG 497
            ||||||||.||:..:|.|||||||.||...|||:||.||.::|..|||||.|:..||||:|:.:.
  Fly  1525 IPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTSDQS 1589

Frog   498 PYQ 500
            .|:
  Fly  1590 DYK 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lck	XP_012812855.2	SH3_Lck	59..112	CDD:212938
		SH2_Src_family	117..217	CDD:199827	53/99 (54%)
		PTKc_Lck_Blk	231..494	CDD:270652	163/265 (62%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	53/95 (56%)
		PTKc_Frk_like	1319..1587	CDD:270653	165/267 (62%)
		Pkinase_Tyr	1328..1580	CDD:285015	155/251 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I6825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D248674at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920