Protein Alignment ret and btl

DIOPT Version :10

• Sequence 1: XP_012822323.2
• Gene: ret / 100495902
• XenbaseID: XB-GENE-485176
• Length: 1102
• Species: Xenopus tropicalis
• Sequence 2: NP_729956.1
• Gene: btl / 39564
• FlyBaseID: FBgn0285896
• Length: 1052
• Species: Drosophila melanogaster
• Alignment Length: 1201
• Identity: 298/1201 - (24%)
• Similarity: 466/1201 - (38%)
• Gaps: 352/1201 - (29%)

 Frog     8 LCLLSLLQVASGLYFLTKDYDEN-LYVDQPAGTLLLHIHVMKDSPHETPHFRLCPNSYLSRISFY 71
            :.|:.::.:.|....|..||..: .|:|..........|::.|........|          ...
  Fly     6 ITLVMIIAIVSAAADLGCDYGHHRCYIDVTVENSPRQRHLLSDMDITLQCVR----------PMA 60

 Frog    72 HWFWIDE---HTGILYLNRSLDRSDYEVFAQGSSLAVQKIILKVSTKPQPFLDNNCDNAPFTRVH 133
            .||:.|:   ...:|.|.|:...:........|......|.|.|..| :| :.|  |.|.|.::
  Fly    61 KWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHK-EP-VGN--DIASFVKL- 120

 Frog   134 LTFRNITSSICSSLKPKDLCFNDKDLSFHIKENKP--------PGKLYKFHPRPIVQSCPNVSVS 190
                    ....:|...||.|...:.|..:|..:|        .|.|::.:..|:......|::|
  Fly   121 --------EDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNIS 177

 Frog   191 YMLISDH------------------------------SYPF---------RFNPNTSEV-SLTHT 215
            ::    |                              ||..         |.||...|| |..||
  Fly   178 WL----HNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHT 238

 Frog   216 MDREERENY----------DLVAKCLLRDSTSEVEVEKSFQIKVDDEDDTAPFLPNGT----DTA 266
            :.. .:..|          ::..:|||.||..|.::....:...|:.||....|...:    |..
  Fly   239 VPM-LKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVT 302

 Frog   267 NVVVEFKRKNGTVLGMLTVWD--------------------------ADSTPVYPAE----ASFK 301
            .::..........||.:.:.|                          :|:|.|....    ||..
  Fly   303 RLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPI 367

 Frog   302 KYAKTIVNNDR-----------------FILENFRVEHSFREVKFQPKGNLIRGTLHEYRLVLNK 349
            ..|.|..:||.                 |..|..|::||.       .||.:           |.
  Fly   368 PTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSL-------SGNTV-----------NL 414

 Frog   350 TMPITRNGSLLVSVLVNDTEFHGP-NGDVMLYF--NVTILPVEIRFPNISYQYTVNRNADRYAQI 411
            ..|:....:      :..|:...| |.::.:|.  |.|:..||                   |..
  Fly   415 ACPVYGKAN------ITWTKDKKPLNRELGVYVQKNWTLRFVE-------------------ATS 454

 Frog   412 EKICIENCKLFEG---VNVNYRLQTDNNTRAFSIIQGRESTFATLIVNDSDALATHESKEVVCTV 473
            |...:.|||:...   :..::.:|.::.||:..||          :|..:..:..:.|..:.|||
  Fly   455 EDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPII----------VVPQNQTVKVNGSLVMKCTV 509

 Frog   474 FATNKHLKEPVKTQIIIVLEGTPLKNEDNCPRSCSESKQKSECEECGGLGSLTGRCQWRQGHGEG 538
            : ::.|   |..:...:||:...|                      .||.|:           |.
  Fly   510 Y-SDLH---PTVSWKRVVLKNASL----------------------DGLKSV-----------EI 537

 Frog   539 ITTNYSTCTPSLL--------------TC--PDGVCDAVESNNS----TICPQDCTTEITIIGGH 583
            ...|::....|::              ||  ..|:   ..||:|    .:.|........::..|
  Fly   538 QNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGL---GRSNSSVYLRVVSPLPPLEIYALLHAH 599

 Frog   584 EKG-ALSGIKAGYGTCFCLLPDKCFCEKNIVEGPLCDDTCKTVIAC----GVFLSFIISVL---- 639
            ..| .|:.|                                |::|.    ..|::|::..|
  Fly   600 PLGFTLAAI--------------------------------TIVALFLLGSAFITFMLRRLRREK 632

 Frog   640 ---LSSYFIHRYHKNSPKPPIASAEMTFRRPAQSYPVSYSSNNARRPSLDSMENQVSVDT----- 696
               |....:|::.|          ::...||........||.:.:.|.:...:.:.:|.|
  Fly   633 LLKLRIETVHQWTK----------KVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGG 687

 Frog   697 ---------FKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRL--KGKAGYTTVAVKMLKE 750
                     ::.|.|..||.||:.|.||..||||.||:||.|.|..|  ..:...|.|||||:||
  Fly   688 TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKE 752

 Frog   751 SASQSELRDLLSEFNLLKQV-NHPHVIKLYGACTQDGPLHLIVEYAKYGSLRSFLRESRKVGPSS 814
            ..:.:::..|:.|..::|.: .|.::|.|.|.|:|.|||.:|||||.:|:|:.||:::|.
  Fly   753 EHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRP----- 812

 Frog   815 LGGDSNRNSS--YLDNP---DERALTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGR 874
             |....|:.|  |||:.   ..:.|...:|..||:||:|||:|||..:.:|||||||||||::|.
  Fly   813 -GAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGY 876

 Frog   875 KMKISDFGLSRDVYEEDSYVKRSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP 939
            .|||:||||:||:.:.:.|.|.:.||:|:||||.|||.:..|.:||||||:|||||||:|.|..|
  Fly   877 VMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQP 941

 Frog   940 YPGI-APERLFNLLKTGYRMEKPENCSDEMYNLMLKCWKQEPDKRPTFGEISKELEKMMVKSRD- 1002
            ||.| :.|.|::.|.||.|||||..||..:|.:|.:||..|...||||.|:.:..:.::.::..
  Fly   942 YPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSN 1006

 Frog  1003 ----YLDLA---ASTPADSLLYDDGLSEEET 1026
                ||||:   ..||..|...||| |:.||
  Fly  1007 PNDAYLDLSMPMLETPPSSGDEDDG-SDTET 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ret	XP_012822323.2	RET_CLD1	20..140	CDD:465485	24/123 (20%)
		CA_like	160..242	CDD:481204	26/139 (19%)
		RET_CLD3	252..368	CDD:465516	25/166 (15%)
		RET_CLD4	392..494	CDD:465517	19/104 (18%)
		PTKc_RET	711..1000	CDD:173631	137/297 (46%)
btl	NP_729956.1	Ig	143..215	CDD:472250	10/75 (13%)
		Ig strand B	160..164	CDD:409570	0/3 (0%)
		Ig strand C	175..179	CDD:409570	1/3 (33%)
		Ig strand E	197..201	CDD:409570	0/3 (0%)
		Ig strand F	211..215	CDD:409570	2/3 (67%)
		Ig_3	247..333	CDD:464046	14/85 (16%)
		Ig	398..479	CDD:472250	21/123 (17%)
		Ig strand B	412..416	CDD:409393	1/14 (7%)
		Ig strand C	423..427	CDD:409393	0/9 (0%)
		Ig strand E	445..449	CDD:409393	1/3 (33%)
		Ig strand F	459..464	CDD:409393	2/4 (50%)
		Ig strand G	472..475	CDD:409393	0/2 (0%)
		IG_like	492..583	CDD:214653	21/130 (16%)
		Ig strand B	503..507	CDD:409444	0/3 (0%)
		Ig strand C	516..520	CDD:409444	0/3 (0%)
		Ig strand E	549..553	CDD:409444	0/3 (0%)
		Ig strand F	563..568	CDD:409444	2/4 (50%)
		Ig strand G	576..579	CDD:409444	1/2 (50%)
		Protein Kinases, catalytic domain	700..1000	CDD:473864	143/305 (47%)