DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rps6ka2 and S6k

DIOPT Version :9

Sequence 1:	XP_002942396.3	Gene:	rps6ka2 / 100495717	XenbaseID:	XB-GENE-487242	Length:	732	Species:	Xenopus tropicalis
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	419	Identity:	189/419 - (45%)
Similarity:	260/419 - (62%)	Gaps:	43/419 - (10%)

- Green bases have known domain annotations that are detailed below.

Frog    15 FSVYLH----KKSRTKTSSFNRYE--DEGIVKEIDISHH---------------VKEGFEKAEPS 58
            |.:.||    :..:.:.|..:|.|  |..:..|:.|:.|               |..|..|..|.
  Fly    11 FDLELHDLELQDDKARDSDDDRIELDDVDLEPELCINLHQDTEGQETIQLCEENVNPGKIKLGPK 75

Frog    59 QFELLKVLGQGSYGKVFLVRKVKGSDSEQLYAMKVLRKATL--KVRDRVRSRMERDILAEVNHPF 121
            .|||.||||:|.|||||.|||..|.|:.:.:|||||:||::  ..:|...:|.||:||..|.|||
  Fly    76 DFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAERNILEAVKHPF 140

Frog   122 IVKLHYAFQTEGKLYLILDFLRGGDLFSRLSKEVMFTEEDVKFYLAELALALDHLHSFGIIYRDL 186
            ||:|.|||||:|||||||::|.||:||..|.:|.:|.|:...|||:|:.|||.|||..|||||||
  Fly   141 IVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHLHKLGIIYRDL 205

Frog   187 KPENILLDEEGHIKITDFGLSKESIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMF 251
            ||||||||.:||:|:|||||.||.|......::|||||||||||::.|.||.::.||||.|.|||
  Fly   206 KPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAVDWWSLGALMF 270

Frog   252 EMLTGSLPFQGKDRKETMALILKAKLGMPQFLSSEAQCLLRALFKRNPCNRLGAGLDGVEEIKRH 316
            :||||..||..::||:|:..||||||.:|.:|:.||:.|:|.|.||....|||:|.:....::.|
  Fly   271 DMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSGPEDAAAVQIH 335

Frog   317 SFFSTIDWNNLYRKEIKPPFKPAVGRPEDTFHFDPEFTSRTPTDSPG---IPPSANTHNLFRGFS 378
            .||..::|:::..:.::||.||.:...:|...||..||.:.|.|||.   :..|||.  :|:||:
  Fly   336 PFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESANL--IFQGFT 398

Frog   379 YVAPNLDYNPHDSYNSSVHPIVQQLHGSN 407
            ||||:               |::.:|.:|
  Fly   399 YVAPS---------------ILEDMHRAN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rps6ka2	XP_002942396.3	STKc_RSK_N	64..380	CDD:270734	165/320 (52%)
rps6ka2	XP_002942396.3	STKc_RSK3_C	410..702	CDD:271080
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	166/322 (52%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	167/322 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010