DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myo5a and Mhc

DIOPT Version :9

Sequence 1:XP_031755040.1 Gene:myo5a / 100495365 XenbaseID:XB-GENE-1004102 Length:1888 Species:Xenopus tropicalis
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:2057 Identity:565/2057 - (27%)
Similarity:921/2057 - (44%) Gaps:409/2057 - (19%)


- Green bases have known domain annotations that are detailed below.


 Frog     4 SELYTKHARVWIPDPEEVWKSAEILKDYKPGDTVLRLRLEEGTDLEYRLDAKTKELPPLRNPDIL 68
            |:.|......||||.:|.:...|| |..| || ::.:.|:.|   |.| |.|::::..: ||...
  Fly    29 SKPYDSKKSCWIPDEKEGYLLGEI-KATK-GD-IVSVGLQGG---EVR-DIKSEKVEKV-NPPKF 85

 Frog    69 VGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLPIYGSDIINAYSGQNMG 133
            ....|:..::.|:.|.|||||:.|:. :||||||.|:..||||||::.|:|.:.....|.|:...
  Fly    86 EKIEDMADMTVLNTPCVLHNLRQRYY-AKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRN 149

 Frog   134 DMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVSGS-------ASETN 191
            ::.|||||:::.||..|..:..|||::::||||||||.:.|..:.|||||..|       .|:.:
  Fly   150 EVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKTENTKKVIAYFATVGASKKTDEAAKSKGS 214

 Frog   192 VEERVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRILGAHMRTYLLEKSRVVFQAEEE 256
            :|::|:.:||::|:.|||||.||||||||||:|.|.|....::.||.:.||||||:||:.|...|
  Fly   215 LEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLE 279

 Frog   257 RNYHIFYQLCASASLPEFKMLRLGTAN--DFHYTKQGGSPVIEGVDDQREMKNTRQACTLLGIGD 319
            |:||||||: .|.|:|..|.:.|.|.|  |:|...| |...:..:||..|...|.||..:||...
  Fly   280 RSYHIFYQI-MSGSVPGVKDICLLTDNIYDYHIVSQ-GKVTVASIDDAEEFSLTDQAFDILGFTK 342

 Frog   320 SYQMGIFRILAAILHLGNVEFKSRDSDSCLVPPKHAPLNIFCDLMGVEYEEMSHWLCHRKLVTAA 384
            ..:..::||.||::|:|.::||.|..:................|.|.:..|:...|...::....
  Fly   343 QEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGN 407

 Frog   385 ETYIKPISRLQATNARDALAKHIYAFLFNWIVCHVNKALHSSTKQNSFIGVLDIYGFETFEINSF 449
            |...:..:..|.||:..||.|.::..||.|:|...|:.|.:..|:..|||||||.|||.||.|.|
  Fly   408 EFVTQGRNVQQVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGF 472

 Frog   450 EQFCINYANEKLQQQFNLHVFKLEQEEYMKEQIPWTLIDF-YDNQPCINLIEAKMGILDLLDEEC 513
            ||.|||:.||||||.||.|:|.||||||.:|.|.|..||| .|...||:|||..||||.:|:||.
  Fly   473 EQLCINFTNEKLQQFFNHHMFVLEQEEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEES 537

 Frog   514 KMPKGSDSTWAQKLYNTHLKKSALFEKPR-----LSNVAFIIKHFADKVEYQCEGFLEKNKDTVF 573
            ..||.:|.|:::||.||||.|||.|:||:     .....|.|.|:|..|.|...|:||||||.:.
  Fly   538 MFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLN 602

 Frog   574 EEQIKVLKASKKKFTLLTELFQEEEQILSPTSSAPPSGRTLLSRTGLRSLKPKPEQTSKEHKK-- 636
            :..:...|.|:.|  ||.|:|.:.         |..||....::.|             ..||  
  Fly   603 DTVVDQFKKSQNK--LLIEIFADH---------AGQSGGGEQAKGG-------------RGKKGG 643

 Frog   637 ---TVGHQFRNSLHLLMETLNATTPHYVRCIKPNDFKYPFTFDSKRAVQQLRACGVLETIRISAA 698
               ||...::..|:.||.||.:|.||:||||.||:.|.|...|:...:.||...||||.|||...
  Fly   644 GFATVSSAYKEQLNSLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRK 708

 Frog   699 GFPSRWTYQEFFSRYRVLMKQ--KDVLSDRKQTCKNVLEKLI-LDKDKYQFGKTKIFFRAGQVAY 760
            |||:|..|.:|..||:::..:  :.|..|:|.|  .::.|.| |.:|:|:.|.||:|||||.:..
  Fly   709 GFPNRMMYPDFKMRYKIMCPKLLQGVEKDKKAT--EIIIKFIDLPEDQYRLGNTKVFFRAGVLGQ 771

 Frog   761 LEKIRADKLRMACIRIQKTIRGWLLRKKYLRM---RKAAITIQRYVRGY-QARCYAQF------- 814
            :|:.|.::|......:|...||:|.||.:.::   |.|...:||.:|.| |.|.:..:       
  Fly   772 MEEFRDERLGKIMSWMQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVK 836

 Frog   815 ----LRRTQAAII-----IQKFQRMYVVRQKYR-HMQSI--------TLALQSYMRGYAARKRFQ 861
                :.|.:..|.     .:|.:.::....|.| .::::        |..|.|......|.:.:|
  Fly   837 PLLNVSRIEDEIARLEEKAKKAEELHAAEVKVRKELEALNAKLLAEKTALLDSLSGEKGALQDYQ 901

 Frog   862 ---GMLRAHKATIIQKHVRGWLARVTYKRNLSAIVYLQCCYRRMMAKRELKKLKIEARSVE---- 919
               ..|.|.| ..::..:|....|:|.:.:....::.|    :..|.:|:..||.:...:|    
  Fly   902 ERNAKLTAQK-NDLENQLRDIQERLTQEEDARNQLFQQ----KKKADQEISGLKKDIEDLELNVQ 961

 Frog   920 ---------------------HYKKLNNGM-ENKIMQ-------------LQRKVDEQNKDNKSL 949
                                 |..:|.|.: :.|.||             .:.|::..||....|
  Fly   962 KAEQDKATKDHQIRNLNDEIAHQDELINKLNKEKKMQGETNQKTGEELQAAEDKINHLNKVKAKL 1026

 Frog   950 LERLTHLEVTYNTEKDKLRSDVDRLRHFEEEAKNAANRMVSLQDELARLRKELQQTQTEKNK--- 1011
            .:.|..||.:...|| |:|.||::.:...|.........|:   :|.|.:|||:||...|:|   
  Fly  1027 EQTLDELEDSLEREK-KVRGDVEKSKRKVEGDLKLTQEAVA---DLERNKKELEQTIQRKDKELS 1087

 Frog  1012 -IEERAE-------KYQTETEKLVAELR--------EQNALLKAEKEELNLL--IQEQAKKMTE- 1057
             |..:.|       |:|.:.::|.|.:.        |:.|..||||:..:|.  ::|..:::.| 
  Fly  1088 SITAKLEDEQVVVLKHQRQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEA 1152

 Frog  1058 --------DMEKKIIEETKQLELELNDERLRYQNLLNEYSRLEERYDDL-------KDEINTMSP 1107
                    ::.||...|..:|..:|.:..:::::.|   :.|.::::|.       .|::|.:  
  Fly  1153 GGATSAQIELNKKREAELSKLRRDLEEANIQHESTL---ANLRKKHNDAVAEMAEQVDQLNKL-- 1212

 Frog  1108 PKPGHKRTDSTHSSNESEYTFSSEITESEDYPYRNEEPADRKTPLDMSLFLKLQKRVKE----LE 1168
                  :..:....|| .|...:::....|: ..||:.|..|      :..:||..:.|    |:
  Fly  1213 ------KAKAEKEKNE-YYGQLNDLRAGVDH-ITNEKAAQEK------IAKQLQHTLNEVQSKLD 1263

 Frog  1169 QEKQVMQD-DLDKKEEQIIRAKI---MEEAKTP---------TRGTELE-------YESLKRQEL 1213
            :..:.:.| |..||:..|..:.:   :|||::.         :..|:||       .||.:|..|
  Fly  1264 ETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQLSKIKISLTTQLEDTKRLADEESRERATL 1328

 Frog  1214 ESENKKLKNELNELRRAITEKASPDATGPGGTVYKVLLEQMTSVSEELEVRKEEVLILRSQLVSQ 1278
            ..:.:.|:::|:.||..:.|:|                |....:..:|.....|..:.||:..| 
  Fly  1329 LGKFRNLEHDLDNLREQVEEEA----------------EGKADLQRQLSKANAEAQVWRSKYES- 1376

 Frog  1279 MEAIPHKDDKDTMTDSMVLSEDVQKMKDKRE--IAQAYTGMKETN----SLETIERNLPPDYQAL 1337
                          |.:..||::::.|.|.:  :|:|...::..|    .||..::.|..:.:  
  Fly  1377 --------------DGVARSEELEEAKRKLQARLAEAEETIESLNQKCIGLEKTKQRLSTEVE-- 1425

 Frog  1338 NEDGELWLVYDGLKQANRVLESQLQSQKKAFEN-------EVEALRGEIQALKEE-NNRQQQLLA 1394
                :|.|..|   :||.:..: .:.::|||:.       :|:.|..|:.|.::| .|...:|..
  Fly  1426 ----DLQLEVD---RANAIANA-AEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFR 1482

 Frog  1395 QNLQLPPEARIEASLQHEITRLTNENLFFEELYADEPMKYQSYRISLYRRIIDLMEQLEKQDKTV 1459
            ..     .|..|...|.|..|..|:||      |||              :.||::|:.:..:.:
  Fly  1483 LK-----GAYEEGQEQLEAVRRENKNL------ADE--------------VKDLLDQIGEGGRNI 1522

 Frog  1460 RKLKKQLKVFAKKIGELEVG---------QMEN------VSPGQIVDEPIRPVNIPRKEKDFQGM 1509
            .:::|..|....:..||:..         |.||      :...|:..|..|  .|..||::|:..
  Fly  1523 HEIEKARKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDR--RIQEKEEEFENT 1585

 Frog  1510 LEYKKEDELKLVKNLILELKPRGVAVNLIPGLPAYI--LFMCLRHADYLNDD---------QKVR 1563
            .:..:.....:..:|..|.|.:..|:.:...|.|.|  |.:.|.||:..|.:         |:::
  Fly  1586 RKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQKNIKRYQQQLK 1650

 Frog  1564 SLLTSTINGIKKILKKRGDDFETVSFWLSNSCRFLHCLKQYSGEEGFMKHNT---TRQNEHCLTN 1625
            .:.|:    :::..:.|.|..|.    |..|.|..:.|:....|...:....   .||.|.    
  Fly  1651 DIQTA----LEEEQRARDDAREQ----LGISERRANALQNELEESRTLLEQADRGRRQAEQ---- 1703

 Frog  1626 FDLAEYRQVLSDLAIQ--IYQQLVRVLENILQPMIVSGMLEHETIQGVSGVKPTGLRKRTSSIAD 1688
             :||:..:.|::::.|  ......|.||:.||.:       |..:..:.........|...::.|
  Fly  1704 -ELADAHEQLNEVSAQNASISAAKRKLESELQTL-------HSDLDELLNEAKNSEEKAKKAMVD 1760

 Frog  1689 EGTYTLDSIVRQLNTFHSIMCQHGMDPELIKQVVKQMFYIIGAVTLNNLLLRKDMCSWS--KG-- 1749
            ......:....|         .|....|.:::.::|.        :..|.:|.|....:  ||  
  Fly  1761 AARLADELRAEQ---------DHAQTQEKLRKALEQQ--------IKELQVRLDEAEANALKGGK 1808

 Frog  1750 ---MQIRYNVSQLEEWL---------RDKNLMNSSAK---------------ETLEPLI-QAAQL 1786
               .::...|.:||..|         ..|||..|..:               |.::.|: :..|.
  Fly  1809 KAIQKLEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQK 1873

 Frog  1787 LQVKKKTDEDAEAICSMCNALTTAQIVKVLNLYTPVNEFEER 1828
            ::..|:..|:||.|.::       .:.|.......:.|.|||
  Fly  1874 IKTYKRQIEEAEEIAAL-------NLAKFRKAQQELEEAEER 1908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myo5aXP_031755040.1 MYSc_Myo5 83..754 CDD:276831 284/693 (41%)
IQ 768..789 CDD:197470 7/20 (35%)
IQ 791..813 CDD:197470 8/25 (32%)
IQ 816..838 CDD:197470 4/26 (15%)
IQ 865..886 CDD:197470 5/20 (25%)
SMC_prok_B 905..>1477 CDD:274008 141/685 (21%)
Myo5a_CBD 1514..1888 CDD:271262 67/363 (18%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 16/43 (37%)
MYSc 81..777 CDD:214580 293/724 (40%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 284/693 (41%)
Myosin_tail_1 842..1897 CDD:279860 233/1194 (20%)
V_Alix_like 1557..1877 CDD:187408 64/358 (18%)
ATP-synt_B <1671..1771 CDD:304375 19/111 (17%)
TMPIT 1739..>1825 CDD:285135 14/102 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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