DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mast3 and dop

DIOPT Version :9

Sequence 1:	XP_031761059.1	Gene:	mast3 / 100494808	XenbaseID:	XB-GENE-5928376	Length:	1492	Species:	Xenopus tropicalis
Sequence 2:	NP_001261884.1	Gene:	dop / 39686	FlyBaseID:	FBgn0267390	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	1860	Identity:	685/1860 - (36%)
Similarity:	896/1860 - (48%)	Gaps:	525/1860 - (28%)

- Green bases have known domain annotations that are detailed below.

Frog    59 NRKSLVVGSPSPTL---SRPLSPLSVPTAGSSPLDSPRNFSTSASVNFPFARSHGPRADRADGRR 120
            :|.|||..|.:...   ||..||.|     :||:||||..|.......|..|....|...|||||
  Fly   317 HRLSLVTNSAAVAAAGGSRTHSPYS-----ASPVDSPRLNSPMPFAFAPIKRIASCRGVVADGRR 376

Frog   121 WSLASLPSSGYGTNTPSSTLSSSSSSQERLHQL-------------------------------- 153
            ||:||||||||||...||.|||..||||.|:||
  Fly   377 WSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVAAGACCAEHLKQHCPK 441

Frog   154 ----------------PFQPT---------------ADELHFL--------------SKHFRSTE 173
                            |.:||               ..||...              |....|..
  Fly   442 HCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAGGGAANGGSSANSSGS 506

Frog   174 SITDEDGRRSPCMRPRSRSLSPGRASSNFDNEIIMMNHVYKERFPKATAQMEERLQDIITH---- 234
            |.....||.||..||||||||....|...||||.:||.:|||||||||.||||||:..|..
  Fly   507 SAMQVGGRMSPYFRPRSRSLSSPSRSPIVDNEIAVMNTLYKERFPKATQQMEERLKLFINENKSA 571

Frog   235 ----FCPSQTLPLADGVLGFIHHQIIELARDCLDKSKGALITSRYFLELQEKLEKMLQDAHNRSE 295
                |..||.      ::.|:|||::|:|||||.||:..||||:||.||.|.||::|.:...:|
  Fly   572 ACNSFRDSQP------IVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLERLLVETKEKS- 629

Frog   296 SEEVMFTNHLARKLLMVIARPARLLECLEFDPEQFYHLLEAAEGQAKVGQGIKTDIPRYIINQLG 360
            .|.....|.:.:|||::|:|||||||||||||::||.|||||||.||....||.|||:|||::||
  Fly   630 PEAAAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKADIPQYIIHKLG 694

Frog   361 LTKDPLEEIVQLDHYDTE---------------------------------SSLLLD-------- 384
            |.:||:.|: |.:..:|:                                 |||.||
  Fly   695 LNRDPIAEL-QQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLALDAIAMDSGS 758

Frog   385 -----QEDYQDPCIS--STPS-------------------------------------------- 398
                 |:..|.|..:  :.||
  Fly   759 GTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITGGSAATATGS 823

Frog   399 ---RKKPCESDFETIKLISNGAYGAVYLVRHKEMRQRFAMKKINKQNLILRNQIQQVFVERDILT 460
               :..|.|:||:.:||||||||||||||:||..|||||||||||.|||||||::|||.|||||:
  Fly   824 GAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQVFAERDILS 888

Frog   461 FAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMSRMYFAETVLALEYLHNYG 525
            ||:|||||||:|||||::|||:||||||||||.|||||:||||.||:|.||||||||:||||:||
  Fly   889 FADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVLAVEYLHSYG 953

Frog   526 IVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMNMTTNLYEGHIEKDTREFLDKQVCGTPEYIAPE 590
            ||||||||||||||:|||||||||||||:|||::.||||||:|:.:||:|.||||.|||||||||
  Fly   954 IVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVYGTPEYIAPE 1018

Frog   591 VILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIIWPGGEE-ALPTDAQDLI 654
            ||||||||||||||:|||||||||:|||||||:|.||||...::|:|.||..|: .:..:|:|:|
  Fly  1019 VILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWPVQAEAKDII 1083

Frog   655 TRLLRQNPLERLGT-GGAQEVKQHTFFLPLDWNGLLRQKAEFVPQLEAEDDTSYFDTRSERYHHL 718
            ::||:|||.:|||| .||.|:|:|.:||.:|||.||||||||||||..:|||||||||.:||:|.
  Fly  1084 SQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFDTRMDRYNHD 1148

Frog   719 ASEEDEETNDDESSVEIRQFSSCSHRFSKV-YSSSEHLATQLNLSFS--------STERSHSDEK 774
            ...||  |:|.:.:.....|:|.:.::.|. ||.|.| ||..:...:        |:..|.:.|.
  Fly  1149 LGGED--TDDTDDTPVFGSFNSYTPQYRKQHYSWSRH-ATPTSTDGAKPTGPPPLSSLPSRAQET 1210

Frog   775 EEHSDRWERTLSIEEEKNRLGPENRLRSWTSSGSSHHSWLSER------------SASPNVLTST 827
            ...:.....|.::.:.|:.:|..:...|.:.|||:.|..:..:            |:|...:.||
  Fly  1211 PAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNKFLNTPQLRKLDLSSSCLKVPST 1275

Frog   828 CSLDTMPKFAFS------SEEESSDHKPERP-----------------TFTLGEMKGTPPKPTSL 869
            ...|.:|:...:      :|.....|..::|                 |.|:.....||| ||..
  Fly  1276 PDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQRHSMPPNTTTIISTPATPP-PTQT 1339

Frog   870 ---------CADIVSLSRTRLRSNSTGAKNSTPRPLEAGVTRRLRG--------------QRDTP 911
                     .|.:.|.||:...|:.|.:.:.:|:     :.|:.:|              :.:|.
  Fly  1340 QATMAATPPTATVGSFSRSTPESSQTDSDDFSPQ-----INRKRKGVCARDILPRFSISIEDETI 1399

Frog   912 EKHSSST--------------------------GSRVP--------KSASVSALSLIITADDFGS 942
            ...||||                          ||.|.        ||||...|||:.:.|:...
  Fly  1400 SAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRSRSIVKSASALGLSLMTSLDNSQL 1464

Frog   943 GS----LASPISPRSLSSNPSSRDSSPSRESTVAVSSLRPPIIIHSSGKKYGFTLRAIRVYMGES 1003
            .:    :.||....:.||..||||:||.||.:..|::|:|||||....:.:|||:..||||.|::
  Fly  1465 AAQLCGIQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKPPIIIRRGPRGFGFTVHTIRVYYGDT 1529

Frog  1004 DVYTVHHMVWSIEDGSPAHEAGLRAGDLITHVNGESVLGLVHMDVVELLLKSGSKVSLRTTPLEN 1068
            |.||:||:|.::::||||.|||||..|||||||||:|.||.|..|::|||..|..|:||.||||:
  Fly  1530 DFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQLLLSGGEHVTLRATPLEH 1594

Frog  1069 TSIKIGPARKNSCKGRMAR----RTKKSRKRE-SQDRKRSLFKKISKQ--------------STV 1114
            |||:.|..:::..:.::|:    |.||..||| .:.||.|||::||.:              |..
  Fly  1595 TSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRRISSKRANAEMQQYSAGTSSPT 1659

Frog  1115 LQTSRSFS---SGLH----QSLSSSESLPASPTHSLSPGPTTPSRSPAPDAAGDAAS-------- 1164
            ..::|:.|   |..|    ||.::|.|...||:   |..|.||:.|...:..|:|.|
  Fly  1660 TPSARNLSPLDSSYHSSCCQSAANSSSQSTSPS---SSSPNTPTGSSGSNHGGNAGSVAVAPSAL 1721

Frog  1165 ----PQSTSP-------------------CSSTPSSPAGHI-----RPSSLQCLTPKLSGQRYKV 1201
                |.:..|                   ..:.|.||.|.:     |||:|..|..||......:
  Fly  1722 SVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVSPTGVVPQLYQRPSTLHGLKHKLHAATAVI 1786

Frog  1202 -------------------------GRRKSTSSIPPSPLACTPSPVPQAPSSPQRSPSPLLPSHP 1241
                                     .||||...||.||||.||||.| .||||.||||||  :.|
  Fly  1787 AGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPLSPLARTPSPSP-LPSSPTRSPSPL--AFP 1848

Frog  1242 RSGH-CGLQGKT--LSP----PTIVRQSARNRATD----------APRSPLLKRVQSVEKMAAFL 1289
            ..|| .|....|  .||    ||:  |:|.|..|.          .|.||||:|..|.:::.. .
  Fly  1849 LVGHQPGASNTTQSYSPGSTLPTL--QTAVNANTKKAGFARTKSAEPSSPLLRRALSPDRLHP-R 1910

Frog  1290 SSGRKASP--------------VDIQHWEDTVDMLEGMSESRTRDWSSEKHERDPEVVVMRRLNL 1340
            |:..|.||              |....|..|    .|.|.|
  Fly  1911 SAETKISPLCCSPPIKQPTHQRVVTTTWRST----PGGSAS------------------------ 1947

Frog  1341 SERRDSFKKQEAVQEVSFDEPDTGAGEV---APDNKKIGSCSSLWERLPHQTSWIQARTGISTSV 1402
                                   |||..   ||..:.:       :.:|..:...|.:|.::|.|
  Fly  1948 -----------------------GAGGAVLGAPSVQPL-------QLVPAASEESQRQTAMATVV 1982

Frog  1403 TTQQE------------ASCRLVPQIAVQTSESDEQEKSQGVWECQGFYPL---QLSGKDNCPLV 1452
            :|...            |:|..:|:||.:.......:.|..|.|  ||.|.   ...|:.:....
  Fly  1983 STTAAGTDPSATAVVTLANCEPLPRIAEEKDSPTSTQDSSSVSE--GFMPAIEEFAEGESSSSPT 2045

Frog  1453 TWLSEPTAASSDRNLPESGKVSECQAPFALSSKRDSKKTS 1492
            ..|.:||...:... ||       ..|...|.|.|..||:
  Fly  2046 QTLEKPTKVKATEQ-PE-------MEPAGKSKKVDQGKTT 2077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mast3	XP_031761059.1	DUF1908	88..368	CDD:401031	152/364 (42%)
		STKc_MAST	406..685	CDD:270760	209/280 (75%)
		PDZ	980..1061	CDD:214570	45/80 (56%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	152/364 (42%)
		STKc_MAST	834..1115	CDD:270760	209/280 (75%)
		S_TKc	835..1110	CDD:214567	206/274 (75%)
		PDZ_signaling	1506..1587	CDD:238492	45/80 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	446	1.000	Domainoid score	I521
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	969	1.000	Inparanoid score	I324
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		otm48628
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060