DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hspa5 and Hsc70-4

DIOPT Version :9

Sequence 1:	XP_002941690.1	Gene:	hspa5 / 100492570	XenbaseID:	XB-GENE-480060	Length:	655	Species:	Xenopus tropicalis
Sequence 2:	NP_001262586.1	Gene:	Hsc70-4 / 41840	FlyBaseID:	FBgn0266599	Length:	651	Species:	Drosophila melanogaster

Alignment Length:	614	Identity:	401/614 - (65%)
Similarity:	499/614 - (81%)	Gaps:	5/614 - (0%)

- Green bases have known domain annotations that are detailed below.

Frog    33 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 97
            |||||||||||||||::|:|||||||||||.|||||||| :.|||||||||||:..||..|:|||
  Fly     7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTQTIFDA 70

Frog    98 KRLIGRTWNDPSVQQDIKYLPFKVIERKTKPYIQVDIGDQMKTFAPEEISAMVLVKMKETAEAYL 162
            ||||||.::|.:||.|:|:.||:|:....||.|:|...|:.|||.|||||:|||.||||||||||
  Fly    71 KRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETAEAYL 135

Frog   163 GKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKKE-GEKNILVFDL 226
            ||.||:||:||||||||:||||||||||||||||:||||||||||||||||||. ||:|:|:|||
  Fly   136 GKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKAVGERNVLIFDL 200

Frog   227 GGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRR 291
            ||||||||:|:||:|:|||.:|.|||||||||||.|::.||::.:|:|..||:..:.||:::||.
  Fly   201 GGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRALRRLRT 265

Frog   292 EVEKAKRALSSQHQSRIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLDDADLKKSD 356
            ..|:|||.|||..|:.|||:|.|||.||..::|||:|||||.|||||||.||:|.|.||.|.||.
  Fly   266 ACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDAKLDKSV 330

Frog   357 IDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGD--QDTGDLVLLD 419
            |.:||||||||||||:|:|:::.|||||.::.|||||||||||||||.:|.||  |:..||:|||
  Fly   331 IHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQDLLLLD 395

Frog   420 VCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFD 484
            |.||:|||||.||||:.||.|||.:|||::|.|:|.|||||.|.|:||||||.:||||:|||.|:
  Fly   396 VTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFE 460

Frog   485 LTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVTDAEKF 549
            |:||||||||||||||||:||.||||.|||.::.|..:||||||||:.||:.|:|||||.:|||:
  Fly   461 LSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMVNEAEKY 525

Frog   550 AEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETIEKAVEEKIEWLESHQDSDI 614
            ..||:|.||.|..:|.||||.:::|..: |::.|..|:|..|:.||.....|.|:||:::|.:|.
  Fly   526 RNEDEKQKETIAAKNGLESYCFNMKATL-DEDNLKTKISDSDRTTILDKCNETIKWLDANQLADK 589

Frog   615 EEFKAKKKELEEIVQPIVGKLYGGAGAPP 643
            ||::.::||||.:..||:.|||.|||.||
  Fly   590 EEYEHRQKELEGVCNPIITKLYQGAGFPP 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hspa5	XP_002941690.1	HSP70	32..636	CDD:365808	394/605 (65%)
Hsc70-4	NP_001262586.1	PTZ00009	1..612	CDD:240227	395/606 (65%)
Hsc70-4	NP_001262586.1	HSPA1-2_6-8-like_NBD	6..381	CDD:212675	261/374 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D288077at2759
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010