DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1a and para

DIOPT Version :9

Sequence 1:XP_031755311.1 Gene:cacna1a / 100492135 XenbaseID:XB-GENE-1013831 Length:2302 Species:Xenopus tropicalis
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2234 Identity:497/2234 - (22%)
Similarity:868/2234 - (38%) Gaps:702/2234 - (31%)


- Green bases have known domain annotations that are detailed below.


 Frog     2 ILATIIANCIVLAMEQHLPVGDKTPMSERLDDTEPYFIGIFCFETGIKIIALGFAFHKGSYLRNG 66
            |:.||:.|||::.|          |.:..::.||..|.||:.||:.:|::|.||.....:|||:.
  Fly   159 IITTILVNCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDA 213

 Frog    67 WNIMDFVVVLSGIVASTGPEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLL 131
            ||.:||||:....|.......:|..||..||||.||.|:.:|.|:.::.::::::..|..:.:|.
  Fly   214 WNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILT 278

 Frog   132 FFAILIFAIIGLDFYIGKFHTSC-----YDMAGEDIREE---------------------VLCGN 170
            .|::.:||::||..|:|.....|     .|.:..::.:|                     .||||
  Fly   279 MFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGN 343

 Frog   171 DSSSRRCPENTQCLSKW-EGPNNGITQFDNILFAILTVFQCITMEGWTDILYYSNDVFGSAFNW- 233
            .|.:.:|.::..||..: ..||.|.|.||:..:|.|:.|:.:|.:.|.|:...   |..:|..| 
  Fly   344 ISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQL---VLRAAGPWH 405

 Frog   234 -LYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFMK--LRRQQQIERELNGYMEWISKA 295
             |:||.:|.:|||:::||:|.:::..:.:.:::.|...|..:  :|..::........:|..:.|
  Fly   406 MLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANA 470

 Frog   296 EVILAEDDSDIEQRLPYDGALRRPTI------------------KKNKTELLNAEEGEEAIG--- 339
            :...|.|.:..|:...:....:.||.                  .|.|..:.:.|...|::.   
  Fly   471 QAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQ 535

 Frog   340 --------------------DIASVGSPF--ARASIKSAKM------------------------ 358
                                .::..||||  .|.|..|.|.                        
  Fly   536 RQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTY 600

 Frog   359 ---------------------EN----------------SSY-MHK------------------- 366
                                 ||                ||| .|:                   
  Fly   601 QDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMG 665

 Frog   367 -----KERRIR-------------------------------------------------FLIRR 377
                 ||.::|                                                 |:  .
  Fly   666 VSTMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFI--E 728

 Frog   378 MVKTQ-------------------------------AFY-------------------------- 385
            .|:||                               .:|                          
  Fly   729 PVQTQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGID 793

 Frog   386 ----------------WVVLGL------------VALNTLCVAIVHYGQDDRLSEFLYYAEFIFL 422
                            ||.|.:            :.:||:.:|:.|:..:..:...|....:.|.
  Fly   794 VFCVWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFT 858

 Frog   423 GLFMSEMFIKMYGLGTRPYFHSSFNCFDCAVITGSIFEVVWAMVKPGTSFGISVLRALRLLRIFK 487
            ..|..|..:|:..:..:.||...:|.||..::..|:.|:....|:     |:||||:.||||:||
  Fly   859 ATFAIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLELGLEGVQ-----GLSVLRSFRLLRVFK 918

 Frog   488 VTKYWASLRNLVISLLS-SMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEK-------TPAT 544
            :.|.|.:| ||:||::. :|.::.:|.|:|.:.|.:||::||||||..:: |.|       .|..
  Fly   919 LAKSWPTL-NLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYH-DHKDRFPDGDLPRW 981

 Frog   545 NFDTFPAAIMTVFQILTGEDWNAVMYDGIKSQGGVKTGMVFSI-YFIILTLFGNYTLLNVFLAIA 608
            ||..|..:.|.||::|.|| |...|:|      .:..|.|..| :|:...:.||..:||:|||:.
  Fly   982 NFTDFMHSFMIVFRVLCGE-WIESMWD------CMYVGDVSCIPFFLATVVIGNLVVLNLFLALL 1039

 Frog   609 VDNLA----NAQELTKDEQEEEEAANQ--KLAMQKAKEVAEVSPLSATNMSIAAKEQQKNQKTSM 667
            :.|..    :|.....|..:..||.|:  :......:.:|:...|....::....:|...::|:.
  Fly  1040 LSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQ 1104

 Frog   668 SVWEQRTNEIRRQNLMNSREALYSELDPEERWKLSFMRPDVKTHLDRPLVVDPQENRNNNTNKTR 732
            ..|                  ::||                                        
  Fly  1105 ISW------------------IWSE---------------------------------------- 1111

 Frog   733 PGEGRNPIEQRLSQQRAEDYLRKQARFQERGGRGYDMGQEPGRRPRIKEQDIIRDGQ-DLGMQDR 796
             |:|   :.:.:|              .|.|....::|.:          :|:.||. ..|::::
  Fly  1112 -GKG---VCRCIS--------------AEHGDNELELGHD----------EILADGLIKKGIKEQ 1148

 Frog   797 TGEMDGGIRPPQDPHRRHRGGGSKESRSGSPLPRGDGDHRRHRPHR----RTGEDNEDAGGGGGG 857
            | :::..|           |.|.:.:.        .||.:.::|.:    ....|::.|      
  Fly  1149 T-QLEVAI-----------GDGMEFTI--------HGDMKNNKPKKSKYLNNATDDDTA------ 1187

 Frog   858 GGRGGGGGGDRRPRHGRDGMRVREGGGGESEGPEGERRRRHRHAAQSTYESDAKRDDRERRHRRR 922
               .....|..:.|..:|     |...|.:|..|||.:|            ||.::|        
  Fly  1188 ---SINSYGSHKNRPFKD-----ESHKGSAETMEGEEKR------------DASKED-------- 1224

 Frog   923 KEPTAPTPGSGGPNLSTTRPIQDRSRQENQNQQPENMDNIRNTKLVTSEPPAGGGVGGLNHSPAK 987
                          |.....:.:....|                    |.|..|.:  :.|    
  Fly  1225 --------------LGLDEELDEEGECE--------------------EGPLDGDI--IIH---- 1249

 Frog   988 IGNHTNCANNNSVPTGNATPRRTPHPTNSGPPPSAPDPSHTFSNPTETAKGTKTTEHTTVDIPPP 1052
                   |::..:             .:..|....||..:                       ..
  Fly  1250 -------AHDEDI-------------LDEYPADCCPDSYY-----------------------KK 1271

 Frog  1053 FPPPVENAIGQANKIVAVSPLPKKDDEKKEEEEDDDDGEKGPKPMPPYSSMFILSTTNPLRRLCH 1117
            ||            |:|                .|||            |.|.....| ||....
  Fly  1272 FP------------ILA----------------GDDD------------SPFWQGWGN-LRLKTF 1295

 Frog  1118 YIVTMRYFEMCILMVIAMSSIALAAEDPVQPDAP-RNNVLRYFDYVFTGVFTFEMVIKMVDLGLI 1181
            .::..:|||..::.:|.|||:|||.||...|..| ..::|.|.|.:||.:|..||:||.:.||. 
  Fly  1296 QLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGF- 1359

 Frog  1182 LHQGAYFRDLWNFLDFIVVCGALVAFAFSSNQRGGSKGKDISTIKSLRVLRVLRPLKTIKRLPKL 1246
               ..||.:.|.:|||::|..:|:.|..|....||     |...|::|.||.||||:.:.|:..:
  Fly  1360 ---KVYFTNAWCWLDFVIVMVSLINFVASLVGAGG-----IQAFKTMRTLRALRPLRAMSRMQGM 1416

 Frog  1247 KAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGKFFYCTDESKEFQRDCRGEYLVYD--- 1308
            :.|.:.:|.::.::.|:|:|.::|..|||::.||||.||:|.|        .|..|..|.::   
  Fly  1417 RVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFKC--------EDMNGTKLSHEIIP 1473

 Frog  1309 -KSEVKAQKREWKKWPFHYDNVLWALLTLFTVSTGEGWPDVLRHSVDATYEDQGPRPGFRMEMSI 1372
             ::..:::...|.....::|:|..|.|.||.|:|.:||..::..::|:...|:.|    ..|.:|
  Fly  1474 NRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQP----IRETNI 1534

 Frog  1373 F---YVVYFVVF-PFFFVNIFVALIIITFQEQGDKI---MEEYSLEKNER--ACIDFAISAKPLT 1428
            :   |.|:|::| .||.:|:|:.:||..|.||..|.   :|.:..|..::  ..:....|.||| 
  Fly  1535 YMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPL- 1598

 Frog  1429 RHMPQNKQSFQYRMWQFVVSPPFEYTIMALIALNTIVLMMKFHGSSNTYENVLKTFNMVFTSLFS 1493
            :.:|:.:...|..:::.|....|:..||..|.||...:.:..:.:|:||..||...|.:|..:||
  Fly  1599 KAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFS 1663

 Frog  1494 LECLLKIMAFGAPNYFRDAWNIFDFVTVLGSITDIVVTELWDS-IINLSFLRLFRAA---RLIKL 1554
            .||||||.|. ..:||.:.||:||.|.|:.||..:|::::.:. .::.:.||:.|.|   |:::|
  Fly  1664 SECLLKIFAL-RYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVRVAKVGRVLRL 1727

 Frog  1555 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDEEDDDTAITEHNNFRN 1619
            ::....||.||:....|..||..:|||:.::.||:||.||..|.::     .:.:.|.:..||:.
  Fly  1728 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHV-----KEKSGINDVYNFKT 1787

 Frog  1620 FFQALMLLFRSATGEAWHEIMLSCLSGRPCDVGSGLK--EKECGS-EFAYFYFVSFIFLCSFLML 1681
            |.|:::|||:.:|...|..::.:.::...||.....|  ...||| .....:.:|::.:...:::
  Fly  1788 FGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVI 1852

 Frog  1682 NLFVAVIMDNFEYLTRD-SSILGPHHLDEYVRVWAEYDPAAWGRMKYTDLYEMLRLISPPLGLGK 1745
            |:::|||::|:...|.| ...|.....|.|..:|.::||.....::|..|.|.|.::.|||.:.|
  Fly  1853 NMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK 1917

 Frog  1746 KCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDSQLRKEMMAIWP 1810
              |.:  || ::.||:|:...:.::....|.||.:   |....||...::  ..::.:  :|..|
  Fly  1918 --PNK--YK-IISMDIPICRGDLMYCVDILDALTK---DFFARKGNPIEE--TGEIGE--IAARP 1970

 Frog  1811 NMSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKRLQALQEEQNRTPLMFQRMEPPSPT 1875
            :...      ..|..||.....:.|.|.:|...:|:.||:                         
  Fly  1971 DTEG------YEPVSSTLWRQREEYCARLIQHAWRKHKAR------------------------- 2004

 Frog  1876 QDGPLGINALPSSQAGEMGLPEGG 1899
              |..|.:..|.:..|:.|.|:.|
  Fly  2005 --GEGGGSFEPDTDHGDGGDPDAG 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1aXP_031755311.1 Ion_trans 1..267 CDD:395416 86/293 (29%)
Ion_trans 382..620 CDD:395416 81/335 (24%)
Ion_trans 1123..1358 CDD:395416 80/239 (33%)
Ion_trans 1448..1700 CDD:395416 80/259 (31%)
GPHH 1709..1762 CDD:407139 17/52 (33%)
Ca_chan_IQ 1773..1846 CDD:400901 14/72 (19%)
PHA03307 2112..>2292 CDD:223039
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 83/283 (29%)
Na_trans_cytopl 515..648 CDD:288761 18/132 (14%)
Ion_trans 835..1028 CDD:278921 65/206 (32%)
Na_trans_assoc 1054..1296 CDD:284034 65/505 (13%)
Ion_trans 1318..1571 CDD:278921 90/273 (33%)
Na_channel_gate 1561..1613 CDD:240441 12/52 (23%)
Ion_trans 1636..1871 CDD:278921 74/240 (31%)
GPHH 1880..1930 CDD:293510 18/54 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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