DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tec and Src42A

DIOPT Version :9

Sequence 1:	XP_031751261.1	Gene:	tec / 100491653	XenbaseID:	XB-GENE-6076361	Length:	648	Species:	Xenopus tropicalis
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	378	Identity:	156/378 - (41%)
Similarity:	234/378 - (61%)	Gaps:	17/378 - (4%)

- Green bases have known domain annotations that are detailed below.

Frog   264 LYQYEWYSRNMNRSKAE-QLLKSEDKEGGFIVRNS-SQAGLYTVSLYTKYGGEGSTCIRHYHIKE 326
            |.:..||.|.:.|.:|| :||..|::.|.|::|:| |:...|::|:     .:|.| ::||.|::
  Fly  1205 LNEKSWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSV-----RDGDT-VKHYRIRQ 1263

Frog   327 TQYPKKYYLAEKHVFNTIPEMIEYHKHNAAGLVTRLRYPVCSKNKSAPTTAGFSY---DKWEINP 388
            .. ...:::|.:..|.|:.|::|::..::.||...|..|.....|  |.|.|.|:   |:|||:.
  Fly  1264 LD-EGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEK--PVTEGLSHRTRDQWEIDR 1325

Frog   389 SELTFMKELGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHLKLVQLYGVC 453
            :.|.|:::||||.||.|..|.|.....||||.::.|.|..:||:.||::|.||.|.||:|||.||
  Fly  1326 TSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVC 1390

Frog   454 TQQRPIYIVTEFMEHGCLLNYLRQRHGQ---FSPDILLSMCQDVCEAMSYLEQNNFIHRDLAARN 515
            |.:.||||:||.|:||.||.||:...|:   .....|:.|...:...|:|||..|:|||||||||
  Fly  1391 TVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAAGMAYLESQNYIHRDLAARN 1455

Frog   516 CLVNDAGVVKVSDFGMTRYVLDDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVF 580
            .||.|..:||::|||:.|.:.:|:|.:..||:||:||:.||..|||:||.||||||||:|:.|:.
  Fly  1456 VLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELV 1520

Frog   581 TEGKMPFESYSNVEVVEMVTRGERLYRPKLATKIIYSVMVACWHEKPEGRPKF 633
            |.|::|:...:|.||:..|..|.|:.:|......:|.:|:.|||:.|..||.|
  Fly  1521 TYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTF 1573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tec	XP_031751261.1	PH_Btk	27..168	CDD:269944
		SH3_Tec	204..259	CDD:212838
		SH2_Tec_Itk	262..368	CDD:198259	31/105 (30%)
		PTKc_Tec_Rlk	386..645	CDD:270685	117/251 (47%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	29/97 (30%)
		PTKc_Frk_like	1319..1587	CDD:270653	120/255 (47%)
		Pkinase_Tyr	1328..1580	CDD:285015	116/246 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910