DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf43 and rnf13

DIOPT Version :9

Sequence 1:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis
Sequence 2:	NP_957338.1	Gene:	rnf13 / 793981	ZFINID:	ZDB-GENE-040426-772	Length:	377	Species:	Danio rerio

Alignment Length:	366	Identity:	83/366 - (22%)
Similarity:	141/366 - (38%)	Gaps:	104/366 - (28%)

- Green bases have known domain annotations that are detailed below.

Frog    13 LLLTVTLQAVASAMGTTEREMDVKALIRVTPLQAEESGGVGQGNLT--LEGLFARVAEISPAEGR 75
            :||::.:..:::....|...:.:.|.:.:.|::|:.| .....|.|  .:.|.||.....|:||.
Zfish     1 MLLSLGMLMLSATQIYTIFTVQIFAFLNLLPVEADIS-AYSFDNKTENFDDLPARFGYRLPSEGL 64

Frog    76 ---LLQFHPLSLCNTSEDDQTKPGFISIVKLETPDRDTQPCLSLANKARLAGERGAHAVL---FD 134
               |:...|.:.|               |.:|.|.:          :..|:   .|..||   ||
Zfish    65 KGFLIGARPENAC---------------VPIEPPPQ----------RENLS---SAFIVLIRRFD 101

Frog   135 ITNDRGALQQLQQPAGINQPVVLIWGPDAEKLMDVVNKNKEALVKIEV------QEQPKWLHHD- 192
            ...|...|.  .|.||..  ..::...|::.|:.:.:::.:.|.:|::      :|....|..|
Zfish   102 CNFDIKVLH--AQKAGYK--AAIVHNVDSDDLISMGSEDLDILKQIDIPSVFIGEEAANSLKEDY 162

Frog   193 ----------------------IWILLTVAGTVMFFVLYAVARLLCRQPPPQDSIQQQTLLAISR 235
                                  |..|:.|...::..|::.:.:.          :|.:.....||
Zfish   163 IYEKGGHVILMPDFSLPLEYYLIPFLIIVGICLILIVVFMITKF----------VQDRHRARRSR 217

Frog   236 LGTRRYQQRMLKDQRASGGWVETASTSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWL- 299
            |  |:.|.:.|...:...|        .|..||||||:|:.:|:.||:|||.|.||..||||||
Zfish   218 L--RKDQLKKLPIHKFKKG--------DSYDVCAICLDEYEEGERLRVLPCSHAYHCKCVDPWLT 272

Frog   300 RQNHTCPLCMY-------------DILDSGTPPRPLAHRAP 327
            :...|||:|..             |.:|||.....::...|
Zfish   273 KTKKTCPVCKQKVVPSDGDSESDSDSVDSGGEDNEVSENTP 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	20/104 (19%)
		HRD1	<244..366	CDD:227568	34/98 (35%)
		RING-H2_RNF43_like	267..311	CDD:319580	26/57 (46%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	24/40 (60%)
		DUF4573	523..643	CDD:373595
rnf13	NP_957338.1	PA_C_RZF_like	23..180	CDD:239038	36/189 (19%)
rnf13	NP_957338.1	zf-RING_2	238..282	CDD:290367	25/43 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920