DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf43 and rnf150b

DIOPT Version :9

Sequence 1:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis
Sequence 2:	NP_001017554.1	Gene:	rnf150b / 792211	ZFINID:	ZDB-GENE-050417-470	Length:	419	Species:	Danio rerio

Alignment Length:	331	Identity:	79/331 - (23%)
Similarity:	138/331 - (41%)	Gaps:	60/331 - (18%)

- Green bases have known domain annotations that are detailed below.

Frog    10 SLWLLLTVTLQAVASAMGTTEREMDVKALIRVT---PLQAE------ESGGVGQGNLTLEGLFAR 65
            |.|||....:..:.......|:|....|.:.:|   |..||      |.|..|:.:|..|   ||
Zfish    15 STWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYVDPDTAEVRTEKTECGRYGEHSLKRE---AR 76

Frog    66 VAEISPAEGRLLQFHPLSLCNTSE--DDQTKPGFISIVKLETPDRDTQPCLSLANKARLA-GERG 127
            .....||..     |....|:.|.  ..:....:|:::        ::...:..:|.|.| |...
Zfish    77 GVLAMPAAP-----HDRHACDPSGRFTPRAHGAWIALI--------SRGNCTYKDKIRHAVGHNA 128

Frog   128 AHAVLFDI--TNDRGALQQLQQPAGINQPV-VLIWGPDAEKLMDVVNKNKEALVKIEV--QEQPK 187
            :..|:|::  :|....:....|  ||:..| ::|..|...:|:.::.:|....:.|.:  :...|
Zfish   129 SAVVIFNVGSSNPNETITMPHQ--GISDVVAIMIPEPKGRELVLLMERNITVHMHITIGTRNLQK 191

Frog   188 WLHHDIWILLTVAGTVM------FFVLYAVARLLCRQPPPQDSIQQQ----TLLAISRLGTRRYQ 242
            ::.....:.::::..::      :.|.|.:.|.  |....:|..|::    ...|||:|..|..:
Zfish   192 YVSRTSVVFVSISFIILMIISLAWLVFYYIQRF--RYANARDRNQRRLGDAAKKAISQLQVRTIR 254

Frog   243 QRMLKDQRASGGWVETASTSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWLRQNHTCPL 307
            :   .||          .|.|....||:|:|.:.....:|||||.|.:|..||||||..:.|||:
Zfish   255 K---GDQ----------ETESDFDNCAVCIEGYKPNDVVRILPCRHLFHKCCVDPWLVDHRTCPM 306

Frog   308 CMYDIL 313
            |..:||
Zfish   307 CKMNIL 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	20/107 (19%)
		HRD1	<244..366	CDD:227568	27/70 (39%)
		RING-H2_RNF43_like	267..311	CDD:319580	21/43 (49%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	20/39 (51%)
		DUF4573	523..643	CDD:373595
rnf150b	NP_001017554.1	PA_GRAIL_like	45..182	CDD:239037	32/154 (21%)
		UPF0233	<196..>221	CDD:299753	2/24 (8%)
		zf-RING_2	265..308	CDD:290367	20/42 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920