DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf43 and RNF43

DIOPT Version :9

Sequence 1:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis
Sequence 2:	XP_011523257.1	Gene:	RNF43 / 54894	HGNCID:	18505	Length:	869	Species:	Homo sapiens

Alignment Length:	752	Identity:	293/752 - (38%)
Similarity:	396/752 - (52%)	Gaps:	143/752 - (19%)

- Green bases have known domain annotations that are detailed below.

Frog     5 RLQLASLW-LLLTVTLQA-------VASAMGTTEREMDVKALIRVTPLQAEESGGVGQGNLTLEG 61
            :||||:|| .||..||||       |.:|...:||..:.||:|||.||:.:.:|.:   ||||||
Human     6 QLQLAALWPWLLMATLQAGFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKL---NLTLEG 67

Frog    62 LFARVAEISPAEGRLLQFHPLSLCNTSEDDQTKPGFISIVKLETPDRDTQPCLSLANKARLAGER 126
            :||.||||:||||:|:|.|||.|||.|:||..:||||||||||:|.|..:||||||:|||:||||
Human    68 VFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGER 132

Frog   127 GAHAVLFDITNDRGALQQLQQPAGINQPVVLIWGPDAEKLMDVVNKNKEALVKIEVQEQPKWLHH 191
            ||.|||||||.||.|.:|||||.|:..|||||||.||||||:.|.||::|.|:||::|.|.|..:
Human   133 GASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDY 197

Frog   192 DIWILLTVAGTVMFFVLYAVARLLCR----QPPPQDSIQQQTLLAISRLGTRRYQQRMLKDQRAS 252
            |:|||:||.||:...:|.:|.|:.||    :|.|   :||:|..|||:|.|||||...   ::|.
Human   198 DVWILMTVVGTIFVIILASVLRIRCRPRHSRPDP---LQQRTAWAISQLATRRYQASC---RQAR 256

Frog   253 GGWVETASTSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWLRQNHTCPLCMYDILDSGT 317
            |.|.::.|:.||.||||||||||::|||||::.|.||:|..||||||.|:.||||||::|.:..:
Human   257 GEWPDSGSSCSSAPVCAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLCMFNITEGDS 321

Frog   318 ------PPRPLAHRAPS-QTQLWGRYPGSARLMSHLP------PHGTPMVFPTPNNSLFLPRAPY 369
                  |.|  :::.|. :..|..::||.|..  |||      |..:.:..| |....|||....
Human   322 FSQSLGPSR--SYQEPGRRLHLIRQHPGHAHY--HLPAAYLLGPSRSAVARP-PRPGPFLPSQEP 381

Frog   370 YLDHTHH---------------------------W---------QMPEQMAMQMRTHR-RGAEGT 397
            .:...||                           |         |.|....:.:|..| ..:.|:
Human   382 GMGPRHHRFPRAAHPRAPGEQQRLAGAQHPYAQGWGLSHLQSTSQHPAACPVPLRRARPPDSSGS 446

Frog   398 RELGISPGCQDSSGYLPDDPGSDSSSGPCHGSSSE---NCTDISLHCLHGTSSSSVHSSQSNQED 459
            .|    ..|.:.||||.|.|.|||||||||||||:   |||||||..:|| |||:..||.|:..|
Human   447 GE----SYCTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDISLQGVHG-SSSTFCSSLSSDFD 506

Frog   460 SSPPALASYLLPQGE----------------LPALNPLLSTQASYASHVHFHQHRHHHYRRN--- 505
               |.:  |..|:|:                |.::.|...||.|  ||||:|:||||||::.
Human   507 ---PLV--YCSPKGDPQRVDMQPSVTSRPRSLDSVVPTGETQVS--SHVHYHRHRHHHYKKRFQW 564

Frog   506 -------QPSMSHSHPHRSKRRTKVSRADPSYYREHRHTTGANGELRSLMVRR---EPRPS---- 556
                   :..:..|.|...:.:.:.....|.......::...:|.|.:....|   ||.|.
Human   565 HGRKPGPETGVPQSRPPIPRTQPQPEPPSPDQQVTRSNSAAPSGRLSNPQCPRALPEPAPGPVDA 629

Frog   557 ---CSRT--CFDPRTNREHPRHQQSMPQAASVVQGSSEPDVATSLRGSRTDPPSRTYRKKKSS-- 614
               |..|  .|:.:.:....||.|...:.     |.|||...:..:.:...|..:.:.....|
Human   630 SSICPSTSSLFNLQKSSLSARHPQRKRRG-----GPSEPTPGSRPQDATVHPACQIFPHYTPSVA 689

Frog   615 ---APSHLPLLYSP----RHCHPANSVQMSESSHPRW 644
               :|...||:..|    :...|........:|.|.|
Human   690 YPWSPEAHPLICGPPGLDKRLLPETPGPCYSNSQPVW 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	71/101 (70%)
		HRD1	<244..366	CDD:227568	54/134 (40%)
		RING-H2_RNF43_like	267..311	CDD:319580	31/43 (72%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	27/39 (69%)
		DUF4573	523..643	CDD:373595	25/140 (18%)
RNF43	XP_011523257.1	Peptidases_S8_S53	<87..186	CDD:299169	69/98 (70%)
RNF43	XP_011523257.1	zf-RING_2	270..312	CDD:290367	29/41 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I21669
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	422	1.000	Inparanoid score	I8785
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38388
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	1	1.000	-	-		FOG0013512
OrthoInspector	1	1.000	-	-		oto159409
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080