DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rnf43 and Rnf43

DIOPT Version :9

Sequence 1:	XP_002935238.2	Gene:	rnf43 / 100491274	XenbaseID:	XB-GENE-952685	Length:	689	Species:	Xenopus tropicalis
Sequence 2:	NP_766036.2	Gene:	Rnf43 / 207742	MGIID:	2442609	Length:	784	Species:	Mus musculus

Alignment Length:	839	Identity:	317/839 - (37%)
Similarity:	414/839 - (49%)	Gaps:	214/839 - (25%)

- Green bases have known domain annotations that are detailed below.

Frog     5 RLQLASLW-LLLTVTLQA-------VASAMGTTEREMDVKALIRVTPLQAEESGGVGQGNLTLEG 61
            :||||.|| .||..||.|       |.:|...:||..:.||:|||.||:.:.:|.:   ||||||
Mouse     6 QLQLAVLWPWLLMATLHAGFGHTGRVLAAAVESERSAEQKAVIRVIPLKMDPTGKL---NLTLEG 67

Frog    62 LFARVAEISPAEGRLLQFHPLSLCNTSEDDQTKPGFISIVKLETPDRDTQPCLSLANKARLAGER 126
            :||.|||::||||:|:|.|||.|||.|:||..:||||||||||:|.|..:||||||:|||:||||
Mouse    68 VFAGVAEVTPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGER 132

Frog   127 GAHAVLFDITNDRGALQQLQQPAGINQPVVLIWGPDAEKLMDVVNKNKEALVKIEVQEQPKWLHH 191
            ||:|||||||.||.|.:|||||.|:.:|||||||.||.|||:.|.||::|.|.||::|.|...::
Mouse   133 GANAVLFDITEDRSAAEQLQQPLGLTKPVVLIWGSDAAKLMEFVYKNRKAYVWIELKEPPAGANY 197

Frog   192 DIWILLTVAGTVMFFVLYAVARLLCR----QPPPQDSIQQQTLLAISRLGTRRYQQRMLKDQRAS 252
            |:||||||.|||...:|.:|.|:.||    :|.|   :||:|..|||:|.|||||...   :||.
Mouse   198 DVWILLTVVGTVFVIILASVLRIRCRPHHSRPDP---LQQRTARAISQLATRRYQAGC---RRAR 256

Frog   253 GGWVETASTSSSVPVCAICLEEFTDGQELRILPCCHEYHLGCVDPWLRQNHTCPLCMYDILD--- 314
            ..|.::.|:.||.||||||||||::|||||::.|.||:|..||||||.|:.||||||::|::
Mouse   257 AEWPDSGSSCSSTPVCAICLEEFSEGQELRVISCLHEFHRTCVDPWLYQHRTCPLCMFNIVEGDS 321

Frog   315 -SGTPPRPLAHRAPS-QTQLWGRYPGSARLMSHLP------PHGTPMVFPTPNNSLFLPRAPYYL 371
             |..|....:::.|. :..|..::||.|..  |||      |..| .|..||....|||.....:
Mouse   322 FSQAPAASPSYQEPGRRLHLIRQHPGHAHY--HLPSAYLLGPSRT-SVARTPRPRPFLPSQEPSM 383

Frog   372 DHTHHWQMPEQMAMQMRTHRRGAEGTRELGISPG------------------------------- 405
            . :.|.::|.      .:|.|..|..:.|.:||.
Mouse   384 G-SRHQRLPR------TSHLRAPEEQQHLAVSPHPYAQGWGLNRLRCTSQHPAACPVALRRARPH 441

Frog   406 ---------CQDSSGYLPDDPGSDSSSGPCHGSSSE---NCTDISLHCLHGTSSSSVHSSQSNQE 458
                     |.:.||||.|.|.|||||||||||||:   ||||:||..:|| |||:..||.|:..
Mouse   442 ESSGSGESYCTERSGYLADGPASDSSSGPCHGSSSDSVVNCTDVSLQGIHG-SSSTFRSSLSSDF 505

Frog   459 DSSPPALASYLLPQGEL------PALN----------PLLSTQASYASHVHFHQHRHHHYRRN-- 505
            |   |.:  |..|:|:|      |::.          |...||.|  ||:|:|:||||||:|.
Mouse   506 D---PLV--YCSPEGDLQGKGIQPSVTSRPRSLDSVVPRGETQVS--SHIHYHRHRHHHYKRQFQ 563

Frog   506 --------QPSMSHSHPHRSKRRTKVSRAD--------------PSYYREHRHTTGANG--ELRS 546
                    :..:..|.|..|..:.:.|..|              |:..|....|..|.|  |..|
Mouse   564 WHGRKPGPETGIPQSMPAASHTQLEPSLPDQQLITPNPTASSMLPNPQRPRALTEPAPGLAEASS 628

Frog   547 LMVRREPRPSCSRTCFDPRTNREHPRHQQSMPQAASVVQGSSEPDVATSLRGSRTDPPSRTYRKK 611
            .....:|.||.............||..::.        .|.||| :.|||      ||..|....
Mouse   629 PSPSPKPNPSGLLNLQKSSLTVRHPHRKRR--------GGPSEP-LPTSL------PPDLTVHTA 678

Frog   612 KSSAPSHLPLLYSPRHCHPANSVQMSESSHPRWAEEV------------RLLHSRVNSHRENTAM 664
            ....|.     ||||..:|             |..||            ||||........::..
Mouse   679 CPVFPH-----YSPRLAYP-------------WPPEVHPLMFRPPGPDRRLLHEVPGPCYSSSQP 725

Frog   665 MHLY---------------H-------------PPHHNQ------GATEEIEAVCEHAV 689
            :.||               |             |..|.|      |:.||:|.:||.||
Mouse   726 VWLYLNPCQPLGPCLPGEGHSKWTFDSPEGRRCPYSHCQVLPAQPGSEEELEELCEQAV 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf43	XP_002935238.2	ZNRF_3_ecto	80..182	CDD:375639	70/101 (69%)
		HRD1	<244..366	CDD:227568	56/132 (42%)
		RING-H2_RNF43_like	267..311	CDD:319580	31/43 (72%)
		RING-H2 finger (C3H2C3-type)	268..308	CDD:319580	27/39 (69%)
		DUF4573	523..643	CDD:373595	30/135 (22%)
Rnf43	NP_766036.2	zf-RING_2	270..312	CDD:290367	29/41 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..407		13/50 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..478		15/18 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..671		41/171 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I21404
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	422	1.000	Inparanoid score	I8624
OMA	1	1.010	-	-		QHG38388
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	1	1.000	-	-		FOG0013512
OrthoInspector	1	1.000	-	-		oto195207
Panther	1	1.100	-	-	LDO	PTHR16200
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080