DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment XB994119 and Atp8b5

DIOPT Version :9

Sequence 1:	XP_002940236.3	Gene:	XB994119 / 100490503	XenbaseID:	XB-GENE-994120	Length:	1179	Species:	Xenopus tropicalis
Sequence 2:	XP_006538058.1	Gene:	Atp8b5 / 320571	MGIID:	2444287	Length:	1195	Species:	Mus musculus

Alignment Length:	1158	Identity:	727/1158 - (62%)
Similarity:	918/1158 - (79%)	Gaps:	15/1158 - (1%)

- Green bases have known domain annotations that are detailed below.

Frog    11 KKQPEKERRLRANDRDYNLKFKYATNAIKTCKYNIFTFLPLNLFEQFQRVANAYFVFLLILQLIP 75
            :::.|:||.|:||:|.:|..|:|..|:|||.||..|.|||:||||||||:|||||:.||.|||:|
Mouse    30 RQKEEEERILQANNRRFNSLFEYPDNSIKTSKYGFFNFLPMNLFEQFQRLANAYFLILLFLQLVP 94

Frog    76 QVSSLSWFTTVVPLVLVLAVSAVKDATDDYY------------RHKSDNQVNNRTVQVLSNGQFT 128
            |:|||:|:|||:||::||:::.||||.||..            ||:||.|:|||:|.:|.||:..
Mouse    95 QISSLAWYTTVIPLIVVLSITGVKDAIDDVVKWLPGLPSLDLKRHRSDQQINNRSVSILVNGRVE 159

Frog   129 NEKWMNIQVGDIIKLENNNFVTADLLLLSSSEPNGLIYIETAELDGETNLKVKQSLTVTGDLGED 193
            ..||.|:|||||||||||:.||||:||||||||.||.|||||:|||||||||||:::||..:.::
Mouse   160 EIKWRNVQVGDIIKLENNHPVTADMLLLSSSEPYGLTYIETADLDGETNLKVKQAISVTSAMEDN 224

Frog   194 LEQLSRFDGEVVCEAPNNKLDTFTGTLTYQGEKYSLDNGKILLRGCTLRNTDWCFGMVIFAGPDT 258
            ||.||.|:|||.|:.||||||.|:|||:|.|..|.|::.::|||||.:||||||:|:|::.|.||
Mouse   225 LELLSSFNGEVRCDPPNNKLDKFSGTLSYLGNTYLLNHERLLLRGCVIRNTDWCYGLVVYTGQDT 289

Frog   259 KLMQNSGKSTLKRTSIDRLMNILVLWIFVFLAAMCIILAIGNGIWESNQGYYFQVYLPWAEGVTN 323
            |||||||:||.|||.||.|||:||:|||:||..||.:|:||:||||:::|||||.:|||...:|:
Mouse   290 KLMQNSGRSTFKRTHIDHLMNVLVVWIFMFLGGMCFLLSIGHGIWENSRGYYFQAFLPWKHYITS 354

Frog   324 AAFSGFLMFWSYVIILNTVVPISLYVSVEIIRLGNSYYINWDRKMYYPKKDTPAEARTTTLNEEL 388
            :|.|..|:||||.|:|||:||||||||||||||||||||||||||:|..|:.||:||||||||||
Mouse   355 SATSSALIFWSYFIVLNTMVPISLYVSVEIIRLGNSYYINWDRKMFYAPKNMPAQARTTTLNEEL 419

Frog   389 GQIKYIFSDKTGTLTQNIMTFNKCSINGNSYGDVYDYAGNRLEINEHTEKVDFSFNPLADPKFSF 453
            ||::|:|||||||||:|:|.||||||||.:||..||..|..:. ....:|||||:|.||||||||
Mouse   420 GQVQYVFSDKTGTLTENVMIFNKCSINGKTYGYSYDDNGEYVP-KSPKDKVDFSYNHLADPKFSF 483

Frog   454 HDHRLVESVKLGEPATHEFFRLLALCHTAMSEEKKPGELVYQAQSPDEGALVTAARNFGFVFRTR 518
            :|..|||:||..:|..:.||..|:||||.|||||..||||||||||||||||||.|||||||.:|
Mouse   484 YDKTLVEAVKSEDPLVYLFFLCLSLCHTVMSEEKVEGELVYQAQSPDEGALVTATRNFGFVFCSR 548

Frog   519 TPETITVVEMGETKVYELQAILDFNNERKRMSVIVKSPDGRLILYCKGADTIVYELLDQSSEDLK 583
            |||||||:|||:.:||.|.|||||:||||||||||::|:.|::|:|||||||:||||..|...|.
Mouse   549 TPETITVIEMGKIRVYRLLAILDFSNERKRMSVIVRTPEDRVMLFCKGADTIIYELLHPSCASLS 613

Frog   584 ETTTEHLNEFAGEGLRTLVLACKELNPTYFRDWKQRHHEASTSLDDREEKLAKLYEEIEKDLKLL 648
            |.|.:||::||.||||||::|.:||:..||:.|.::|.||..:|::||.|||.:|||||:||.||
Mouse   614 EVTMDHLDDFASEGLRTLMVAYRELDKAYFQTWIKKHGEAWLTLENRERKLALVYEEIERDLMLL 678

Frog   649 GASAIEDKLQDGVPQTIETLSKANIKIWVLTGDKQETAENIGYSCNMLQDEMKEVFIIKGCSPDE 713
            ||:|||||||.|||:||.|||||.||||||||||||||.||.|||.:.:|||..||:::|...:.
Mouse   679 GATAIEDKLQRGVPETIVTLSKAKIKIWVLTGDKQETAVNIAYSCRIFKDEMDGVFMVEGTDRET 743

Frog   714 VLEELRSARRKMNPESFSETNEVNVYLQKKSKKSQIIPDDELKGSDTFGILINGHSLAFALEESM 778
            ||||||:||:||.|||..|::.:|:||.:|.|......|:...|:  :|::|:|:|||:|||.|:
Mouse   744 VLEELRTARKKMKPESLLESDPINMYLARKPKMPFKSLDEVANGN--YGLVISGYSLAYALEGSL 806

Frog   779 EIELLRTACMCTAVICCRVTPLQKAQVVQLVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQE 843
            |.|||||||||..|:|||:|||||||||.|||:|||.|||||||||||:||||.||||||||.||
Mouse   807 EFELLRTACMCKGVVCCRMTPLQKAQVVDLVKRYKKVVTLAIGDGANDISMIKAAHIGVGISNQE 871

Frog   844 GMQAVLSSDFSFAQFRYLQRLLLVHGRWSYIRMCRFLRYFFYKNFTFTLVHFWYGFFCGFSAQTV 908
            ||||.|||||||.||.:||||||||||.||.|||:||.|||||||.||||||||.||.|||||||
Mouse   872 GMQATLSSDFSFCQFHFLQRLLLVHGRLSYNRMCKFLSYFFYKNFAFTLVHFWYAFFNGFSAQTV 936

Frog   909 YDEWFITLYNLVYTSLPVLGMSLFDQDVNDRWSLQFPELYEPGQMNRYFNIKEFIKCVLHGIYSS 973
            ||.||||.|||:||||||||:|||::|||:.|||.:||||||||.|.|||.|||:||:|||||:|
Mouse   937 YDIWFITFYNLIYTSLPVLGLSLFEKDVNETWSLCYPELYEPGQHNLYFNKKEFVKCLLHGIYNS 1001

Frog   974 LILFFIPFGAMYESVREDGRAISDYQSFALMAQTCLLLVVSVQIGLDTAYWTAVNQFFIWGSMAV 1038
            .:|||:|.|.::.|.|.||:.|||:|||:|:.||.|:.|:::||.|.|..||.:|..|.|||:.:
Mouse  1002 FVLFFVPMGTVFNSERNDGKDISDFQSFSLLVQTTLIGVMTMQIALRTTSWTMINHTFTWGSLGL 1066

Frog  1039 YFAITFTMYSDGMYLIFTGSFPFIGTARNTLNQPGVWLAIFLTTVLCVLPVVAFRFLRSELFPST 1103
            ||.|...:.|||:.|.:...|.|:|.|||:|:||.:||.:.|:|:||::|::.:.|||..|:|..
Mouse  1067 YFCILILLCSDGLCLRYPSIFNFLGVARNSLSQPQIWLCLILSTILCMIPLIGYNFLRPLLWPIN 1131

Frog  1104 GDKIQKKIREAKKRPPPPPPKARLRRTSSRRSGYAFSHQQGYGDLITSGRNFR 1156
            .||:..:|....|.|.|...:.:::..|.|||.|||||:||:|.|||||:..:
Mouse  1132 ADKVLNRIHFCLKHPIPTQVQTKIKHPSLRRSAYAFSHKQGFGALITSGKTLK 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
XB994119	XP_002940236.3	P-type_ATPase_APLT_Dnf-like	36..980	CDD:319770	638/955 (67%)
Atp8b5	XP_006538058.1	P-type_ATPase_APLT_Dnf-like	54..1008	CDD:319770	638/956 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I7517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H99882
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D23350at32523
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.010