Protein Alignment mast4 and dop

DIOPT Version :9

• Sequence 1: XP_002934250.3
• Gene: mast4 / 100489840
• XenbaseID: XB-GENE-6043694
• Length: 2469
• Species: Xenopus tropicalis
• Sequence 2: NP_001261884.1
• Gene: dop / 39686
• FlyBaseID: FBgn0267390
• Length: 2139
• Species: Drosophila melanogaster
• Alignment Length: 2310
• Identity: 745/2310 - (32%)
• Similarity: 1027/2310 - (44%)
• Gaps: 755/2310 - (32%)

 Frog     6 LECEGAADGSDRSSSSSLSSSGSQTLSEGDMKPQSGGSSTDCESERNAERRRGQ---EGRAHSGA 67
            :|....:|.:...|||..:::.:.|:| |...|:...|:.      |..|.|.|   ..|.....
  Fly    65 IEAMSISDSASAESSSGATATATATMS-GSPVPKRHLSTA------NLSRIRPQSSYSARVLIFD 122

 Frog    68 EEDEELDSILSPPSMLCRKCSNPEVSTRSCKSVKY------KSQLSDD---GRILRRG-----SL 118
            :.|:|..:..:..:.....|::   |.:||..::.      |..:.:|   |..:.|.     |.
  Fly   123 DSDQEAAAAAAALAAASSSCNS---SVKSCSGLELLPTSPAKLSIGNDSTNGSSMMRNLNLTKSS 184

 Frog   119 GGALTG----------RYLLPAGAAQQ----VWSASTEASNLVRMRSQALGQSAPSLTASLKELS 169
            .|.|:|          ..||...:.||    :.:.|.|.|||:|||..:||:|||.||
  Fly   185 SGGLSGSSSSLHSRGYTALLRKISYQQHTNSLRAVSGETSNLLRMRHSSLGKSAPCLT------- 242

 Frog   170 LPRRGSFLTPRSLSPTPTSP----CSP-----------CSPL--------YAFHFWSCRTS---- 207
                |::......:|.|..|    .||           |:.:        :..|....|.|
  Fly   243 ----GNYFRHELTAPLPVQPPGFGASPLGGHNISRSGSCAGIGLAKHHHHHHLHGVVMRGSAGGG 303

 Frog   208 -------------NRKSLIGSSQSPAL---PRPHSPLSAHTGSSPQDSPRNFSPSASAHFSFA-- 254
                         :|.||:.:|.:.|.   .|.|||.||    ||.||||..||..   |:||
  Fly   304 AGSGGGSSSGVAHHRLSLVTNSAAVAAAGGSRTHSPYSA----SPVDSPRLNSPMP---FAFAPI 361

 Frog   255 RR--------TDGRRWSLASLPSSGYGTNTPSSTVSSSCSSQEKLHQLPYQPTPDE--------- 302
            :|        .||||||:||||||||||...||.:||.|||||.|:||.:...|..
  Fly   362 KRIASCRGVVADGRRWSVASLPSSGYGTTPGSSNLSSQCSSQEGLNQLAHNIPPGVQEADAAAVA 426

 Frog   303 -----LHFLSKH---FCTESIASDDRCRTP----------------------------------- 324
                 ...|.:|   .|...:|...:..||
  Fly   427 AGACCAEHLKQHCPKHCALLLAVSQKQLTPQPPKPTQLQPQKSMTAACVNCCAELSVTCGGQQAG 491

 Frog   325 ---------------------------LRPRSRSL-SPGRTPACCDHEIIMMNHVYKERFPKATA 361
                                       .||||||| ||.|:| ..|:||.:||.:|||||||||.
  Fly   492 GGAANGGSSANSSGSSAMQVGGRMSPYFRPRSRSLSSPSRSP-IVDNEIAVMNTLYKERFPKATQ 555

 Frog   362 QMEDRLQDIVTNYSPDSVLPLADG--VLSFTHHQIIELARDCLDKSHLGLITSRYFLELQQKIEK 424
            |||:||:..:......:.....|.  ::.|.|||::|:|||||.||...||||:||.||.:.:|:
  Fly   556 QMEERLKLFINENKSAACNSFRDSQPIVRFVHHQVLEMARDCLHKSEAKLITSQYFYELSENLER 620

 Frog   425 LLHEAHERSESGELAFIKQLVQRILIVIARPARLLECLEFDPEEFYYLLEAAEGHAKEGQGIKTD 489
            ||.|..|:|... .|.:..:::::|::|:|||||||||||||:|||.||||||||||....||.|
  Fly   621 LLVETKEKSPEA-AAELNGVIKKLLLIISRPARLLECLEFDPQEFYELLEAAEGHAKAMPVIKAD 684

 Frog   490 IPRYIISQLGLNKDPLEEI---------------------------------------------- 508
            ||:|||.:||||:||:.|:
  Fly   685 IPQYIIHKLGLNRDPIAELQQELRETQQMCSEQVTVDADPLHPGGSLLLNSPLTSAAKQLSSLAL 749

 Frog   509 -ALLSNYDSGTA---ETPET-------------------DESISSSN-----KSLKI-------- 537
             |:..:..||||   :.|:|                   :|...||:     .|.|:
  Fly   750 DAIAMDSGSGTATPQQPPQTPVATCDTAPSFALAISQMNEEKGGSSSAVGGGSSSKVAGAEGITG 814

 Frog   538 ------------RRKPCESDFETMKLISNGAYGAVYLVRHKETRQRFAMKKINKQNLILRNQIQQ 590
                        :..|.|:||:.:||||||||||||||:||.||||||||||||.|||||||::|
  Fly   815 GSAATATGSGAQQPSPQENDFDIVKLISNGAYGAVYLVKHKTTRQRFAMKKINKNNLILRNQVEQ 879

 Frog   591 AFVERDILTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLLKNIGPLPVDMARMYFAETVL 655
            .|.|||||:||:|||||||||||||::|||:||||||||||.||||||||||.||||.|||||||
  Fly   880 VFAERDILSFADNPFVVSMYCSFETKKHLCLVMEYVEGGDCGTLLKNIGPLPADMARFYFAETVL 944

 Frog   656 ALEYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEGHIEKDAREFLDKQVC 720
            |:||||:||||||||||||||:|::||||||||||||:||||:.||||||:|:.:.|:|.||||.
  Fly   945 AVEYLHSYGIVHRDLKPDNLLITALGHIKLTDFGLSKMGLMSLATNLYEGYIDSETRQFSDKQVY 1009

 Frog   721 GTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEDLFGQVISDEINWPEKEDAP 785
            |||||||||||||||||||||||:|||||||||:|||||||:|.|:||...::|:|.||:.||.|
  Fly  1010 GTPEYIAPEVILRQGYGKPVDWWSMGIILYEFLIGCVPFFGETTEELFAHTVNDDIEWPDSEDWP 1074

 Frog   786 -PSDAQDLITLLLRQNPLERMGT-GGAYEVKQHPFFCALDWNSLLRQKAEFIPQLESEDDTSYFD 848
             .::|:|:|:.||:|||.:|:|| .||.|:|:|.:|..:||||||||||||:|||..:|||||||
  Fly  1075 VQAEAKDIISQLLQQNPRDRLGTQSGALEMKEHEYFLGMDWNSLLRQKAEFVPQLSHDDDTSYFD 1139

 Frog   849 TRSEKYHH-METEEEDDTNDE----DFSMEIRQFSSSSHRFSKVFSSIDQLMQSKVEEKDDSTDK 908
            ||.::|:| :..|:.|||:|.    .|:....|:....:.:|:             .....|||.
  Fly  1140 TRMDRYNHDLGGEDTDDTDDTPVFGSFNSYTPQYRKQHYSWSR-------------HATPTSTDG 1191

 Frog   909 SKDLSLPPVESLSWSSEYSEMQQLSISTSSETENPK-------------------QCHNG----- 949
            :|....||:.||  .|...|....::..:|....||                   ..|:|
  Fly  1192 AKPTGPPPLSSL--PSRAQETPAATVGATSTGALPKLKSGMGSGSGSGSGSGSGSASHDGVVNKF 1254

 Frog   950 ----------------------------SLLPKFAISSDIE----RDELCSEEPKETEKSTHEPE 982
                                        .||....|.:|.|    :..|....|..|::......
  Fly  1255 LNTPQLRKLDLSSSCLKVPSTPDADYLPELLHNVTIGNDAELRMLKHYLQQPNPGATQRMQQRHS 1319

 Frog   983 DSPQEDLDATTP-----------VSISSSTVSVSSFS------------EHLDQINGR------- 1017
            ..|......:||           ::.:..|.:|.|||            :...|||.:
  Fly  1320 MPPNTTTIISTPATPPPTQTQATMAATPPTATVGSFSRSTPESSQTDSDDFSPQINRKRKGVCAR 1384

 Frog  1018 ---------------SESADSTDNSSKPANET---TSHMARQRLENTE----KQKMSGKVTKSIS 1060
                           |..:.||:|.:.|..::   ..|..:....:|.    |...|..:.||.|
  Fly  1385 DILPRFSISIEDETISAGSSSTENMNLPREQSPLALQHQPKSMDGSTSGSSVKHHRSRSIVKSAS 1449

 Frog  1061 ASALSLMIPGD----VYSVSPLGSPISPLSISSDPSSRDSSPSRESSISSSSPKQPIIIQSSGKK 1121
            |..||||...|    ...:..:.||....:.||..||||:||.||.|...::.|.||||:...:.
  Fly  1450 ALGLSLMTSLDNSQLAAQLCGIQSPGGGGNGSSTASSRDTSPCRELSPLVTNLKPPIIIRRGPRG 1514

 Frog  1122 FGFTLQAIRVFVGDSDIYTVHHIVWSVEEGSAAYQAGLKAGDLITHINGEPVHGLVHTEVIELLL 1186
            ||||:..|||:.||:|.||:||:|.:|:|||.|::|||:..|||||:|||.|.||.||:|::|||
  Fly  1515 FGFTVHTIRVYYGDTDFYTMHHLVMAVDEGSPAFEAGLRPADLITHVNGEAVQGLFHTQVLQLLL 1579

 Frog  1187 KSGSKVAITTTAFENTSIKTGPARRNSYKSRMV-----RRTKKTKKKENIERRRSFFKKLAKQPS 1246
            ..|..|.:..|..|:|||::|..:|:..:|::.     |:.|:||::.:.:|:.|.|:::
  Fly  1580 SGGEHVTLRATPLEHTSIQSGGRKRDLMQSKLAKKGVNRQKKQTKREHDKKRKTSLFRRI----- 1639

 Frog  1247 PLLHTSRSFSCLNRSLSSGESLPASPT-HSLSPRSP---TPSCRSTPDFPSGTNSSQSSSPSSSA 1307
                :|:..:...:..|:|.|.|.:|: .:|||...   :..|:|     :..:||||:|||||:
  Fly  1640 ----SSKRANAEMQQYSAGTSSPTTPSARNLSPLDSSYHSSCCQS-----AANSSSQSTSPSSSS 1695

 Frog  1308 PNSPAGSG-----------------------------------HI-------------------- 1317
            ||:|.||.                                   |:
  Fly  1696 PNTPTGSSGSNHGGNAGSVAVAPSALSVQLPSAPPPTQLVLLPHVGAVVGSNPTSVGNVPVSPTG 1760

 Frog  1318 -------RPSTLHGLGPKL--------GGQRYRS-----------------GRRKSAGSIPLSPL 1350
                   ||||||||..||        ||....:                 .||||.|.||||||
  Fly  1761 VVPQLYQRPSTLHGLKHKLHAATAVIAGGGNANNPAGGLKTLHTTNNNSLPNRRKSVGHIPLSPL 1825

 Frog  1351 ARTPSPTPQPPSPQRSPSPLH----GHSVGNSKATPNFPAKMHSP----PTIVRHV--------- 1398
            ||||||:|.|.||.||||||.    ||..|.|..|.::     ||    ||:...|
  Fly  1826 ARTPSPSPLPSSPTRSPSPLAFPLVGHQPGASNTTQSY-----SPGSTLPTLQTAVNANTKKAGF 1885

 Frog  1399 VRPKSAEPPRSPLLKRVQSEEKLSPSYCCEKKHLCSRKHNLEVTKEEIHKQPLQRDLALQSLEEN 1463
            .|.|||| |.||||:|..|.::|.|                                  :|.|
  Fly  1886 ARTKSAE-PSSPLLRRALSPDRLHP----------------------------------RSAE-- 1913

 Frog  1464 VCDVPACTRVKPVEQGCLKRPVSRKVGRQESLDELDKEKLKAKIVMKKKDLPERQDSLLKQSLMH 1528
                   |::.|:   |...|:
  Fly  1914 -------TKISPL---CCSPPI------------------------------------------- 1925

 Frog  1529 DLHNELGNPVTVAEQEKEDKSYQNLIKRTNLSEHRLTTYESRSGGIMFKDTLSKSVISRSNGGCM 1593
                             :..::|.::         .||:.|..||              |..|..
  Fly  1926 -----------------KQPTHQRVV---------TTTWRSTPGG--------------SASGAG 1950

 Frog  1594 DGQLHGHGPQAAENIHISCEIKKAPSSCDRVILSRDDNVDKASSACT--ANSELIRKKKSLEEKE 1656
            ...|.....|..:.:..:.|..:..::...|:.:.....|.:::|..  ||.|.:  .:..|||:
  Fly  1951 GAVLGAPSVQPLQLVPAASEESQRQTAMATVVSTTAAGTDPSATAVVTLANCEPL--PRIAEEKD 2013

 Frog  1657 STFCLVLKSKAHENIQAKPSFLPTESIAPLDNRTCLPNVQSGTVSFAPLKASNSRCENNNDKSGV 1721
            |                     ||                                 :..|.|.|
  Fly  2014 S---------------------PT---------------------------------STQDSSSV 2024

 Frog  1722 IHTELPVRKSPSEFKLEARSVSSLKPIEGTLDIALLSGPKVPKTEYTDILLEKKNQSVAKAEKIS 1786
            ....:|   :..||   |...||..|.: ||:    ...||..||..::....|::.|.:.:..:
  Fly  2025 SEGFMP---AIEEF---AEGESSSSPTQ-TLE----KPTKVKATEQPEMEPAGKSKKVDQGKTTT 2078

 Frog  1787 PNSKNDVAFKSDNQNTLLFSSTSSSSVSLQTAPKR 1821
            |.:.......|..:.::..:..:|.||::.|||::
  Fly  2079 PGTPKTKPHNSGCKTSMTTTKPASPSVTISTAPRK 2113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mast4	XP_002934250.3	DUF1908	236..507	CDD:401031	146/362 (40%)
		STKc_MAST	545..824	CDD:270760	209/280 (75%)
		PDZ_signaling	1109..1195	CDD:238492	47/85 (55%)
dop	NP_001261884.1	DUF1908	344..702	CDD:286070	146/362 (40%)
		STKc_MAST	834..1115	CDD:270760	209/280 (75%)
		S_TKc	835..1110	CDD:214567	207/274 (76%)
		PDZ_signaling	1506..1587	CDD:238492	45/80 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	446	1.000	Domainoid score	I521
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48628
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3124
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.140